Results 131 to 140 of about 55,739 (324)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Understanding epigenetics in health and human diseases – An overview

Journal of Integrative Medicine and Research
Epigenetics, the study of heritable changes in gene expression without alterations to the DNA sequence, is crucial for the complex interplay of genetic and environmental factors influencing human health.
Avarna Agarwal, Prasanta Padhan
doaj   +1 more source

The genetics and epigenetics of animal migration and orientation: birds, butterflies and beyond

Journal of Experimental Biology, 2019
Migration is a complex behavioural adaptation for survival that has evolved across the animal kingdom from invertebrates to mammals. In some taxa, closely related migratory species, or even populations of the same species, exhibit different migratory ...
Christine Merlin, M. Liedvogel
semanticscholar   +1 more source

Delta-like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12

, 2000
The distal portion of mouse chromosome 12 is imprinted. To date, however, Gtl2 is the only imprinted gene identified on chromosome 12. Gtl2 encodes multiple alternatively spliced transcripts with no apparent open reading frame.
Tevendale, M, Johnson, M.H., Takada, S, M.H. Johnson, Ferguson-Smith, A.C., Paulsen, M, T. Freeman, Georgiades, P., Paulsen, M., Baker, J., Freeman, T, Campbell, E., Campbell, E, Tevendale, M., A.C. Ferguson-Smith, Georgiades, P, Freeman, T., P. Georgiades, S. Takada, M. Tevendale, M. Paulsen, E. Campbell, Johnson, M H, Baker, J, Ferguson-Smith, A C, J. Baker, Takada, S.   +26 more
core   +1 more source

Demystifying cancer etiology via 3D genome mapping

, 2020
Ramanand et al. perform the first high-resolution 3D genome mapping via ChIA-PET to capture RNAPII-associated chromatin interactions in normal prostate epithelial and prostate cancer cells.
Pauklin, Siim, Feng, Yuliang
core   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

The Ethical and Policy Implications of Epigenetic Research: An Analysis of the TCPS 2

Canadian Journal of Bioethics
Epigenetics is the study of potentially heritable molecular modifications to DNA and chromatin, which can alter the regulation of gene expression.
Andrea Gretchev, Heide S. Temples, Deborah Dewey, Gillian England-Mason, Luigi Boccuto, Vivian Haley-Zitlan   +5 more
doaj   +1 more source

Fibromyalgia: Genetics and epigenetics insights may provide the basis for the development of diagnostic biomarkers

Molecular Pain, 2018
Fibromyalgia is a disease characterized by chronic widespread pain with additional symptoms, such as joint stiffness, fatigue, sleep disturbance, cognitive dysfunction, and depression.
S. D’Agnelli, L. Arendt-Nielsen, M. C. Gerra, Katia Zatorri, L. Boggiani, M. Baciarello, E. Bignami   +6 more
semanticscholar   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Genetics and epigenetics in primary Sjögren’s syndrome

Rheumatology, 2019
Primary Sjögren’s syndrome (pSS) is considered to be a multifactorial disease, where underlying genetic predisposition, epigenetic mechanisms and environmental factors contribute to disease development.
J. Imgenberg-Kreuz, A. Rasmussen, K. Sivils, G. Nordmark   +3 more
semanticscholar   +1 more source