Results 191 to 200 of about 55,739 (324)

Regulation of term and preterm labor: genetics and epigenetics. [PDF]

Front Genet
Sun K, Wang N, Liu Y, Gao L.
europepmc   +1 more source

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

Advanced Science, EarlyView.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye, Wen‐jing Luo, Lu Li, Wen‐di Shuai, Ling Zhou, You‐fa Duan, Xue Chen, Jun‐kai Zhang, Wenlin Huang, Ran‐yi Liu   +9 more
wiley   +1 more source

Editorial: Mechanisms of Epigenetics and Genetics in Leukemogenesis

Frontiers in Oncology, 2022
Yonghui Li, Fei Gao, Shujun Liu
doaj   +1 more source

Genetics, Epigenetics, and Plasticity

, 2011
Charles F. Zorumski
core   +1 more source

Biosocial Criminology: New Directions in Theory and Research

, 2009
Designed to bring criminology into the 21st century by showing how leading criminologists have integrated aspects of the biological sciences into their discipline.
Beaver, Kevin M., Walsh, Anthony
core  

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

How Can Molecules Induce Hemorrhoids? The Role of Genetics and Epigenetics in Hemorrhoidal Disease. [PDF]

Int J Mol Sci
Parol B, Sas O, Mazurek M, Data K, Wozniak S, Domagala Z.   +5 more
europepmc   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Role of genetics and epigenetics in Graves' orbitopathy. [PDF]

Eur Thyroid J
Marinò M, Rotondo Dottore G, Menconi F, Comi S, Cosentino G, Rocchi R, Latrofa F, Figus M, Santini F.   +8 more
europepmc   +1 more source

Recent Progress in Genetics and Epigenetics Research on Diabetic Nephropathy in Malaysia. [PDF]

J Diabetes Res, 2023
Abu Seman N, Othman SH.
europepmc   +1 more source