Results 211 to 220 of about 99,336 (255)
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Genetics and epigenetics of CLL
Leukemia & Lymphoma, 2022Chronic lymphocytic leukemia (CLL) has a heterogeneous biological behavior, which is highly influenced by its immunogenetic, epigenetic, and genomic properties. The remarkably variable clinical course of the disease has been associated with genetic features such as chromosomal abnormalities, the presence of either high or low numbers of somatic ...
Pamella, Paul +3 more
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The Genetics and Epigenetics of Fatigue
PM&R, 2010AbstractFatigue is a common symptom and includes both physical and mental components. It can be associated with a variety of different syndromes and diseases, but in many cases is not associated with other comorbid conditions. Most humans have experienced acute fatigue in relation to different stressors.
Landmark-Høyvik H +7 more
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The genetics of cognitive epigenetics
Neuropharmacology, 2014Cognitive disorders (CDs) are a heterogeneous group of disorders for which the genetic foundations are rapidly being uncovered. The large number of CD-associated gene mutations presents an opportunity to identify common mechanisms of disease as well as molecular processes that are of key importance to human cognition.
Kleefstra, T. +7 more
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Genetics and epigenetics of allergy
Current Opinion in Allergy & Clinical Immunology, 2020Purpose of review Allergic diseases are prototypic examples for gene × environment-wide interactions. This review considers the current evidence for genetic and epigenetic mechanisms in allergic diseases and highlights barriers and facilitators for the implementation of these novel tools both for research and clinical practice.
Ioana, Agache +3 more
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Genetics and epigenetics of osteoarthritis
Maturitas, 2012Osteoarthritis (OA) is a common age-related disease that affects the tissues of the synovial joint, leading to loss of function and pain. It impacts on both patient morbidity and mortality. It is a complex, polygenic disease that lacks any large-effect susceptibility loci.
Reynard LN, Loughlin J
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Genetics and epigenetics of hepatoblastoma
Pediatric Blood & Cancer, 2012AbstractA number of unique genetic features are observed in hepatoblastoma that have provided insights into the origins of hepatoblastoma. Hallmark cytogenetic changes in hepatoblastoma include the acquisition of additional copies of whole chromosomes and a recurring unbalanced translocation involving 1q.
Gail E, Tomlinson, Roland, Kappler
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Genetics and epigenetics of chronic rhinosinusitis
Journal of Allergy and Clinical Immunology, 2023Discerning the genetics and epigenetics of chronic rhinosinusitis (CRS) may optimize outcomes through early diagnostics, personalized and novel therapeutics, and early prognostication. CRS associated with cystic fibrosis and primary ciliary dyskinesia has well-characterized genetic mutations.
Devyani, Lal +5 more
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Genetics, epigenetics, and causation
American Journal of Orthodontics, 1981Abstract Much of the continuing controversy concerning the roles of genomic and nongenomic (epigenetic) processes in the regulation (causation) of growth is resolved by an analysis of the several types of causation. It can be shown that the combination of genomic and epigenetic factors is a necessary cause of craniofacial growth.
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Nutrition and Health, 2006
In the post human-genome area, the challenge is to derive details of heritable variation in relation to how human variation reflects adaptation to the different environments. Heterozygote advantage represents a superior genetic adaptation presumably explaining the presence of the allele at frequencies above those to be expected from a simple ...
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In the post human-genome area, the challenge is to derive details of heritable variation in relation to how human variation reflects adaptation to the different environments. Heterozygote advantage represents a superior genetic adaptation presumably explaining the presence of the allele at frequencies above those to be expected from a simple ...
openaire +2 more sources
Genetics and epigenetics in vitiligo
Journal of Dermatological ScienceVitiligo, a complex autoimmune disorder characterized by melanocyte destruction, arises from an intricate interplay of genetic, epigenetic, immune, and environmental factors. Genome-wide association studies (GWAS) have identified over 50 susceptibility loci, including key genes within the MHC region and those involved in immunity, oxidative stress, and
Ken, Okamura, Tamio, Suzuki
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