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Genetic and epigenetic mechanisms of NASH
Hepatology International, 2015Along with the obesity epidemic, the prevalence of nonalcoholic fatty liver disease (NAFLD) has increased exponentially. The histological disease spectrum of NAFLD ranges from bland fatty liver (hepatic steatosis), to the concomitant presence of inflammation and ballooning which defines nonalcoholic steatohepatitis (NASH).
Mohammed, Eslam, Jacob, George
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2019
Genetic influences on human disease can be understood in the context of essential and exacerbating causes. Alleles are essential causes when they are required for these diseases to occur. Severe diseases with essential genetic causes are rare unless they provide a compensating benefit in evolutionary fitness (accrued through increases in survival and ...
Paul W. Ewald, Holly A. Swain Ewald
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Genetic influences on human disease can be understood in the context of essential and exacerbating causes. Alleles are essential causes when they are required for these diseases to occur. Severe diseases with essential genetic causes are rare unless they provide a compensating benefit in evolutionary fitness (accrued through increases in survival and ...
Paul W. Ewald, Holly A. Swain Ewald
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Common Genetic and Epigenetic Syndromes
Pediatric Clinics of North America, 2015Cytogenetic anomalies should be considered in individuals with multiple congenital anomalies. DNA methylation analysis is the most sensitive initial test in evaluating for Prader-Willi and Angelman syndromes. The timely identification of cytogenetic anomalies allows for prompt initiation of early intervention services to maximize the potential of every
Darius J, Adams, David A, Clark
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Hepatocarcinoma: genetic and epigenetic features
Minerva Gastroenterology, 2017HCC is the third leading cause of cancer-related deaths worldwide, accounting for about 1 million deaths annually. The incidence of HCC is highest in Asia and Africa, where the endemic high prevalence of hepatitis B and hepatitis C strongly predisposes to the development of chronic liver disease and subsequent development of HCC.
Lombardi, Angela +4 more
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[Genetics and epigenetics of schizophrenia].
La Clinica terapeutica, 2013Schizophrenia is a severe psychiatric disorder with an estimate prevalence of 0.3-0.7%. Studies on family aggregation showed a higher incidence of disease among family members of affected people. This observation lead to formulate the hypothesis that schizophrenia could be inheritable, but twin studies have shown a concordance of disease between ...
Fabi, E, Fusco, A, Valiante, M, Celli, R
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Cellular and molecular life sciences : CMLS, 1998
Cis-acting binding sites for transcription activators cannot explain the patterned expression of genes during development, nor a large range of phenomena that result from gene transplacement. Heritable states of transcriptional regression or activation sequences are influenced not only by the chromosomal context of the promoter but also by ...
Gasser SM, Paro R, Stewart F, Aasland R
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Cis-acting binding sites for transcription activators cannot explain the patterned expression of genes during development, nor a large range of phenomena that result from gene transplacement. Heritable states of transcriptional regression or activation sequences are influenced not only by the chromosomal context of the promoter but also by ...
Gasser SM, Paro R, Stewart F, Aasland R
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Inheritable Epigenetics in Genetic Programming
2015Classical genetic programming solves problems by applying the Darwinian concepts of selection, survival and reproduction to a population of computer programs. Here we extend the biological analogy to incorporate epigenetic regulation through both learning and evolution.
William G. La Cava, Lee Spector
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The genetics and epigenetics of orofacial clefts
Current Opinion in Pediatrics, 2001Orofacial clefts (cleft lip, cleft palate) are among the most common of all major birth defects, but very little is known about their causation. Genetic factors are thought to play a major role, and there has been considerable recent effort to map and identify genes that constitute risk factors for clefts.
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Behavioral Genetics, Genetics, and Epigenetics
2013When considering how “nature” and “nurture” contribute to development, psychologists often take the former to mean “influenced by genes.” Traditionally, behavioral geneticists have used twin and adoption studies to assess the extent of genetic influence on various behaviors.
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Osteoarthritis year in review: genetics, genomics, epigenetics
Osteoarthritis and Cartilage, 2021A Ratneswaran
exaly