Results 261 to 270 of about 50,453 (282)
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2019
Genetic influences on human disease can be understood in the context of essential and exacerbating causes. Alleles are essential causes when they are required for these diseases to occur. Severe diseases with essential genetic causes are rare unless they provide a compensating benefit in evolutionary fitness (accrued through increases in survival and ...
Paul W. Ewald, Holly A. Swain Ewald
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Genetic influences on human disease can be understood in the context of essential and exacerbating causes. Alleles are essential causes when they are required for these diseases to occur. Severe diseases with essential genetic causes are rare unless they provide a compensating benefit in evolutionary fitness (accrued through increases in survival and ...
Paul W. Ewald, Holly A. Swain Ewald
openaire +1 more source
Epigenetic Drivers of Genetic Alterations
2010DNA methylation plays a key role in the silencing of cancer-related genes, thereby affecting numerous cellular processes, including the cell cycle checkpoint, apoptosis, signal transduction, cell adhesion, and angiogenesis. DNA methylation also affects the expression of genes involved in maintaining the integrity of the genome through DNA repair and ...
Minoru, Toyota, Hiromu, Suzuki
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Genetic and epigenetic regulation of aging
Current Opinion in Immunology, 2009Many age-associated conditions, such as the decrease in regenerative capacity of tissues, appear to be determined by a decline in the function of specific somatic stem cells. Although it is obvious that the genotype determines the average lifespan of different species, the variation in lifespan of individuals within a species seems to be more affected ...
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Behavioral Genetics, Genetics, and Epigenetics
2013When considering how “nature” and “nurture” contribute to development, psychologists often take the former to mean “influenced by genes.” Traditionally, behavioral geneticists have used twin and adoption studies to assess the extent of genetic influence on various behaviors.
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Inheritable Epigenetics in Genetic Programming
2015Classical genetic programming solves problems by applying the Darwinian concepts of selection, survival and reproduction to a population of computer programs. Here we extend the biological analogy to incorporate epigenetic regulation through both learning and evolution.
William G. La Cava, Lee Spector
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Cancer epigenetics in clinical practice
Ca-A Cancer Journal for Clinicians, 2023Veronica Davalos, Esteller M
exaly
Current biology : CB
The formation of silent epialleles is accompanied by local hypermethylation of the DNA template, and genetically altered, methylation-deficient Arabidopsis mutants generate an increased number of epimutations. But what came first - methylation or epigenetic change?
, Paszkowski, , Scheid
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The formation of silent epialleles is accompanied by local hypermethylation of the DNA template, and genetically altered, methylation-deficient Arabidopsis mutants generate an increased number of epimutations. But what came first - methylation or epigenetic change?
, Paszkowski, , Scheid
openaire +1 more source
Genetics and Epigenetics of Human Retinoblastoma
Annual Review of Pathology: Mechanisms of Disease, 2015Claudia Benavente, Michael Dyer
exaly