Results 131 to 140 of about 2,805,364 (358)

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Whole-genome sequencing in bacteriology: state of the art

Infection and Drug Resistance, 2013
Michael J DarkDepartment of Infectious Diseases and Pathology and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USAAbstract: Over the last ten years, genome sequencing capabilities have expanded exponentially.
Dark MJ
doaj  

Comparison of the DNBSEQ platform and Illumina HiSeq 2000 for bacterial genome assembly

Scientific Reports
The Illumina HiSeq platform has been a commonly used option for bacterial genome sequencing. Now the BGI DNA nanoball (DNB) nanoarrays platform may provide an alternative platform for sequencing of bacterial genomes.
Tongyuan Hu, Jianwei Chen, Xiaoqian Lin, Wenxin He, Hewei Liang, Mengmeng Wang, Wenxi Li, Zhinan Wu, Mo Han, Xin Jin, Karsten Kristiansen, Liang Xiao, Yuanqiang Zou   +12 more
doaj   +1 more source

Development and validation of an rDNA operon based primer walking strategy applicable to de novo bacterial genome finishing.

Frontiers in Microbiology, 2015
Advances in sequencing technology have drastically increased the depth and feasibility of bacterial genome sequencing. However, little information is available that details the specific techniques and procedures employed during genome sequencing despite ...
Alexander William Eastman, Alexander William Eastman, Ze-Chun eYuan, Ze-Chun eYuan   +3 more
doaj   +1 more source

Genome-wide identification of bacterial plant colonization genes

PLoS Biology, 2017
Diverse soil-resident bacteria can contribute to plant growth and health, but the molecular mechanisms enabling them to effectively colonize their plant hosts remain poorly understood. We used randomly barcoded transposon mutagenesis sequencing (RB-TnSeq)
Benjamin J. Cole, Meghan E. Feltcher, R. J. Waters, Kelly M. Wetmore, Tatiana S. Mucyn, E. Ryan, Gaoyan Wang, Sabah Ul-Hasan, Meredith McDonald, Y. Yoshikuni, R. Malmstrom, A. Deutschbauer, J. Dangl, A. Visel   +13 more
semanticscholar   +1 more source

Human Gut Bacteria and Lipidic Nanoparticles: Particle Composition Predicts Structural Transformation and Bacterial Biocompatibility

Advanced Functional Materials, EarlyView.
Lipidic nanoparticles (LNPs) were incubated with 21 gut bacteria frequently associated with the human microbiome. SAXS revealed that ∼75% of tested species induced structural transformations in monoolein LNPs, whereas phytantriol and phospholipid formulations remained unaffected.
Jonathan Caukwell, Emily L. Gulliver, Livia Salvati Manni, Frithjof Herb, Caitlin Welsh, Samuel C. Forster, Andrew J. Clulow, Wye‐Khay Fong   +7 more
wiley   +1 more source

Whole-genome sequencing confirms that Burkholderia pseudomallei multilocus sequence types common to both Cambodia and Australia are due to homoplasy [PDF]

, 2014
Whole-genome sequencing of the four isolates used in this study was supported by Wellcome Trust grant 098051, awarded to the Wellcome Trust Sanger Institute.
Theobald, V, Vandamme, P, Jacobs, J A, Vandamme, Peter, Currie, Bart J, Holden, Matthew T G, Jacobs, Jan, Jacobs, JA, Price, Erin P, Spratt, BG, Peacock, S J, Jacobs, Jan A, Parkhill, J, Holden, Matthew TG, Sarovich, DS, Sarovich, Derek S, Spratt, Brian G, Theobald, Vanessa, De Smet, B, Kham, Chun, Thong, P, Spratt, B G, Heng, Seiha, Holden, MT, Heng, S, Price, EP, Peacock, SJ, Currie, B J, Phe, Thong, Mayo, Mark, Holden, M T G, Parkhill, Julian, Mayo, M, Thong, Phe, Kham, C, De Smet, Birgit, Currie, BJ, Peacock, Sharon J, Sarovich, D S   +38 more
core   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Multiplex Genome Engineering Using CRISPR/Cas Systems

Science, 2013
Genome Editing Clustered regularly interspaced short palindromic repeats (CRISPR) function as part of an adaptive immune system in a range of prokaryotes: Invading phage and plasmid DNA is targeted for cleavage by complementary CRISPR RNAs (crRNAs) bound
Le Cong, F. Ran, David B. T. Cox, Shuailiang Lin, Robert Barretto, Naomi Habib, P. Hsu, Xuebing Wu, Wenyan Jiang, L. Marraffini, Feng Zhang   +10 more
semanticscholar   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source