Results 111 to 120 of about 2,069,635 (294)

Bacterial genomics and vaccine design

Expert Review of Vaccines, 2003
Complete genome sequences are available for an increasing number of pathogenic bacteria. These new data are beginning to make an impact on the understanding of bacterial evolution and virulence. Thus far, however, vaccine development has had little benefit from genomics.
Samantha L, Sampson, Jyothi, Rengarajan, Eric J, Rubin   +2 more
openaire   +2 more sources

Small variable segments constitute a major type of diversity of bacterial genomes at the species level [PDF]

, 2010
Analysis of large scale diversity in bacterial genomes has mainly focused on elements such as pathogenicity islands, or more generally, genomic islands. These comprise numerous genes and confer important phenotypes, which are present or absent depending ...
El Karoui, Meriem, Valérie Barbe, Marie-Agnès Petit, Meriem El Karoui, Denamur, Erick, Petit, Marie-Agnès, Fabrice Touzain, Barbe, Valérie, Erick Denamur, Médigue, Claudine, Touzain, Fabrice, Claudine Médigue, Petit, Marie Agnès   +12 more
core   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Evolution of the G+C content frontier in the rat cytomegalovirus genome [PDF]

, 2008
Within the 230138 bp of the rat cytomegalovirus (RCMV) genome, the G+C content changes abruptly at position 142644, constituting a G+C content frontier. To the left of this point, overall G+C content is 69.2%, and to the right it is only 47.6%.
Gatherer, Derek, Derek Gatherer
core   +2 more sources

Roary : rapid large-scale prokaryote pan genome analysis [PDF]

, 2015
This work was supported by the Wellcome Trust (grant WT 098051).A typical prokaryote population sequencing study can now consist of hundreds or thousands of isolates.
Page, Andrew J, Falush, Daniel, Wong, Vanessa K, Fookes, Maria, Keane, Jacqueline A, Hunt, Martin, Holden, Matthew T G, Parkhill, Julian, Reuter, Sandra, Cummins, Carla A   +9 more
core   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Genomic Analyses of >3,100 Nasopharyngeal Pneumococci Revealed Significant Differences Between Pneumococci Recovered in Four Different Geographical Regions

Frontiers in Microbiology, 2019
Understanding the structure of a bacterial population is essential in order to understand bacterial evolution. Estimating the core genome (those genes common to all, or nearly all, strains of a species) is a key component of such analyses.
Andries J. van Tonder, Andries J. van Tonder, James E. Bray, Keith A. Jolley, Melissa Jansen van Rensburg, Sigríður J. Quirk, Gunnsteinn Haraldsson, Martin C. J. Maiden, Stephen D. Bentley, Stephen D. Bentley, Stephen D. Bentley, Ásgeir Haraldsson, Helga Erlendsdóttir, Karl G. Kristinsson, Angela B. Brueggemann, Angela B. Brueggemann   +15 more
doaj   +1 more source

Adaptations to submarine hydrothermal environments exemplified by the genome of Nautilia profundicola [PDF]

, 2009
Submarine hydrothermal vents are model systems for the Archaean Earth environment, and some sites maintain conditions that may have favored the formation and evolution of cellular life.
Robinson, Jeffrey M, Campbell, Barbara J, Hoda M Khouri, S. Craig Cary, Hanson, Thomas E., Lee Charles K., Jonathan A. Eisen, Wu, Dongying, Eisen, Jonathan A., Barbara J Campbell, Jeffrey M Robinson, Cary, S Craig, Robinson, Jeffrey M., Charles K. Lee, Stein, Lisa Y., Lisa Y Stein, Stein, Lisa Y, Julie L Smith, Thomas E Hanson, Klotz, Martin G., Cary S. Craig, Eisen, Jonathan A, Khouri Hoda M., Khouri, Hoda M, Hanson, Thomas E, Hanson Thomas E., Eisen Jonathan A., Thomas E. Hanson, Dongying Wu, S Craig Cary, Jonathan A Eisen, Lee, Charles K, Smith, Julie L., Klotz Martin G., Cary, S. Craig, Wu Dongying, Charles K Lee, Smith Julie L., Martin G. Klotz, Campbell, Barbara J., Klotz, Martin G, Campbell Barbara J., Barbara J. Campbell, Julie L. Smith, Lee, Charles Kai-Wu, Khouri, Hoda M., Smith, Julie L, Lisa Y. Stein, Jeffrey M. Robinson, Hoda M. Khouri, Martin G Klotz, Stein Lisa Y., Robinson Jeffrey M.   +52 more
core   +2 more sources

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

ClustAGE: a tool for clustering and distribution analysis of bacterial accessory genomic elements

BMC Bioinformatics, 2018
Background The non-conserved accessory genome of bacteria can be associated with important adaptive characteristics that can contribute to niche specificity or pathogenicity of strains.
Egon A. Ozer
doaj   +1 more source