Results 111 to 120 of about 2,805,364 (358)

Genome-Based Prediction of Bacterial Antibiotic Resistance

Journal of Clinical Microbiology, 2018
Clinical microbiology has long relied on growing bacteria in culture to determine antimicrobial susceptibility profiles, but the use of whole-genome sequencing for antibiotic susceptibility testing (WGS-AST) is now a powerful alternative.
Michelle Su, S. Satola, T. Read
semanticscholar   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Bacterial Genomics and Pathogen Evolution [PDF]

Cell, 2006
The availability of hundreds of bacterial genome sequences has altered the study of bacterial pathogenesis, affecting both design of experiments and analysis of results. Comparative genomics and genomic tools have been used to identify virulence factors and genes involved in environmental persistence of pathogens.
Raskin, David M., Seshadri, Rekha, Pukatzki, Stefan U., Mekalanos, John J.   +3 more
openaire   +2 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

The impact of insertion sequences on bacterial genome plasticity and adaptability

Critical reviews in microbiology, 2017
Transposable elements (TE), small mobile genetic elements unable to exist independently of the host genome, were initially believed to be exclusively deleterious genomic parasites.
J. Vandecraen, M. Chandler, A. Aertsen, R. Van Houdt   +3 more
semanticscholar   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

What does the talking?: quorum sensing signalling genes discovered in a bacteriophage genome. [PDF]

PLoS ONE, 2014
The transfer of novel genetic material into the genomes of bacterial viruses (phages) has been widely documented in several host-phage systems. Bacterial genes are incorporated into the phage genome and, if retained, subsequently evolve within them.
Katherine R Hargreaves, Andrew M Kropinski, Martha R J Clokie   +2 more
doaj   +1 more source

Evolution of the G+C content frontier in the rat cytomegalovirus genome [PDF]

, 2008
Within the 230138 bp of the rat cytomegalovirus (RCMV) genome, the G+C content changes abruptly at position 142644, constituting a G+C content frontier. To the left of this point, overall G+C content is 69.2%, and to the right it is only 47.6%.
Gatherer, Derek, Derek Gatherer
core   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Genome sequence of the pattern forming Paenibacillus vortex bacterium reveals potential for thriving in complex environments

, 2010
Background The pattern-forming bacterium Paenibacillus vortex is notable for its advanced social behavior, which is reflected in development of colonies with highly intricate architectures.
Colin Ingham, Lancet, D., Roth Dalit, Bransburg-Zabary Sharron, Alexandra Sirota-Madi, Ingham, C., Nikolaev, V., Sirota-Madi Alexandra, Gutnick, D.L., Yael Helman, Hagi, E., Ben-Jacob, E., Vladimir Galatenko, Olender, T., Nikolaev Vladimir, David L Gutnick, Eshel Ben-Jacob, Brainis, I., Bransburg-Zabary, S., Brodsky Leonid, Tsviya Olender, Sharron Bransburg-Zabary, Gutnick David L, Dena Leshkowitz, Ina Brainis, Roth, D., Olender Tsviya, Brodsky, L., Raja C Mugasimangalam, Ben-Jacob Eshel, Leshkowitz Dena, Mugasimangalam, R.C., Helman, Y., Ingham Colin, Sirota-Madi, A., Hagi Efrat, Leonid Brodsky, Helman Yael, Brainis Ina, Dalit Roth, Doron Lancet, Galatenko Vladimir, Mugasimangalam Raja C, Leshkowitz, D., Galatenko, V., Lancet Doron, Efrat Hagi, Vladimir Nikolaev   +47 more
core   +1 more source