Results 301 to 310 of about 10,751,278 (348)

Conservation assessment of human splice site annotation based on a 470-genome alignment. [PDF]

Nucleic Acids Res
Minkin I, Salzberg SL.
europepmc   +1 more source

Radiation‐Resistant Bacteria Deinococcus radiodurans‐Derived Extracellular Vesicles as Potential Radioprotectors

Advanced Healthcare Materials, EarlyView.
Deinococcus radiodurans‐derived extracellular vesicles (R1‐EVs) provide radioprotection against total‐body irradiation‐induced acute radiation syndrome in mice. R1‐EVs mitigate oxidative damage by scavenging free radicals, promoting intestinal repair, enhancing hematopoietic function, and modulating immune responses. This study highlights the potential
Jeong Moo Han, Godfrey Mwiti, Seo‐Joon Yeom, Jaeyoon Lim, Woo Sik Kim, Sangyong Lim, Seung‐Taik Lim, Eui‐Baek Byun   +7 more
wiley   +1 more source

Reconstruction of Segmental Duplication Rates and Associated Genomic Features by Network Analysis. [PDF]

Genome Biol Evol
Abdullaev ET, Haridoss DA, Arndt PF.
europepmc   +1 more source

3D Microtumors Representing Ovarian Cancer Minimal Residual Disease Respond to the Fatty Acid Oxidation Inhibitor Perhexiline

Advanced Healthcare Materials, EarlyView.
Minimal residual disease (MRD) leads to cancer relapse and poor survival in ovarian cancer. The lack of representative 3D models limits therapy development. The microfluidics‐based high throughput 3D microtumor platform described here generates clinically‐relevant MRD models. The 3D microtumors recapitulate the molecular signatures of MRD from patients.
Xingyun Yang, Mara Artibani, Yongcheng Jin, Aneesh Aggarwal, Yujia Zhang, Sandra Muñoz‐Galvan, Ellina Mikhailova, Lena Rai, Nobina Mukherjee, Ravinash Krishna Kumar, Ashwag Albukhari, Shaohua Ma, Linna Zhou, Ahmed Ashour Ahmed, Hagan Bayley   +14 more
wiley   +1 more source

A structured coalescent model reveals deep ancestral structure shared by all modern humans. [PDF]

Nat Genet
Cousins T, Scally A, Durbin R.
europepmc   +1 more source

Unlocking the Gates: A Novel Diagnostic Molecule for Quantifying Efflux Levels in Gram‐Positive Bacteria

Advanced Healthcare Materials, EarlyView.
Efflux‐mediated resistance compromises antibiotic efficacy, yet rapid detection remains elusive. This study presents a novel phenazinium‐based diagnostic molecule for quantifying bacterial efflux levels in Gram‐positive pathogens. The optimized compound enables precise, real‐time efflux assessment using fluorescence and colorimetric techniques ...
Mrunal Patil, Tatiana Munteanu, Gaël Brasseur, Carolina Ferreira, Sofia Santos Costa, Isabel Couto, Mohd Athar, Elisa Asunis, Attilio Vittorio Vargiu, Miguel Viveiros, Carole DiGiorgio, Frédéric Brunel, Jean‐Manuel Raimundo, Michel Camplo, Olivier Siri, Jean‐Michel Bolla   +15 more
wiley   +1 more source

Integration of therapeutic cargo into the human genome with programmable type V-K CAST. [PDF]

Nat Commun
Liu J, Aliaga Goltsman DS, Alexander LM, Khayi KK, Hong JH, Dunham DT, Romano CA, Temoche-Diaz MM, Chadha S, Fregoso Ocampo R, Oki-O'Connell J, Janson OP, Turcios K, Gonzalez-Osorio L, Muysson J, Rahman J, Laperriere SM, Devoto AE, Castelle CJ, Butterfield CN, Cost GJ, Brown CT, Thomas BC.   +22 more
europepmc   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Identification of the shortest species-specific oligonucleotide sequences. [PDF]

Genome Res
Mouratidis I, Konnaris MA, Chantzi N, Chan CSY, Patsakis M, Provatas K, Montgomery A, Baltoumas FA, Sha CM, Mareboina M, Pavlopoulos GA, Chartoumpekis DV, Georgakopoulos-Soares I.   +12 more
europepmc   +1 more source

Harnessing Nanohybridized Niclosamide for Precision Mpox Therapeutics

Advanced Healthcare Materials, EarlyView.
This study investigates the potential of nanohybridized niclosamide as a therapeutic agent for Mpox, focusing on enhanced bioavailability, improved antiviral efficacy, and controlled drug release achieved through nanoengineering. The research emphasizes significant advancements in formulation strategies, mechanistic insights, and therapeutic outcomes ...
N. Sanoj Rejinold, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source