Results 251 to 260 of about 457,413 (290)

scCompass: An Integrated Multi‐Species scRNA‐seq Database for AI‐Ready

open access: yesAdvanced Science, EarlyView.
scCompass integrates and standardizes transcriptomic data from ≈105 million single cells across 13 species, enabling the identification of stable expression genes and organ‐specific expression genes in humans and mice. It provides scalable datasets for AI model training, pretrained model checkpoints, and user‐friendly platforms for data sharing ...
Pengfei Wang   +29 more
wiley   +1 more source

Engineered Stem Cell Clusters for Extracellular Vesicles‐Mediated Gene Delivery to Rejuvenate Chondrocytes and Facilitate Chondrogenesis in Osteoarthritis Therapy

open access: yesAdvanced Science, EarlyView.
BMSCmotif+miR874/MS system is designed as a gene delivery platform utilizing engineered bone marrow mesenchymal stem cell (BMSC)‐derived extracellular vesicles (EVs) for intercellular communication to achieve sustained delivery of miRNA‐874‐3p. Rejuvenation of chondrocytes and promotion of chondrogenesis are achieved by inhibition of the NF‐κB pathway,
Yuezhou Wu   +7 more
wiley   +1 more source

The complete mitochondrial genome of <i>Halichoeres margaritaceus</i> (Actinopterygii, Labridae). [PDF]

open access: yesMitochondrial DNA B Resour
Huang X   +7 more
europepmc   +1 more source

Single‐Cell Analysis Reveals that Vitamin C Inhibits Bone Metastasis of Renal Cancer via Cell Cycle Arrest and Microenvironment Remodeling

open access: yesAdvanced Science, EarlyView.
3D‐cultured renal cancer cells exhibit stem‐like phenotypes and are more efficient in generating bone metastases. Vitamin C treatment can suppress the development of bone metastasis. Single‐cell transcriptomic analysis reveals that vitamin C inhibits metastasis by inducing tumor cell cycle arrest, suppressing osteoclast differentiation, and reducing ...
Jianye Zhang   +17 more
wiley   +1 more source

The E3 Ubiquitin Ligase ARIH1 Facilitates Colorectal Cancer Progression by Promoting Oxidative Phosphorylation via the Mitochondrial Translocation of K63‐Linked Ubiquitinated PHB1

open access: yesAdvanced Science, EarlyView.
The RBR E3 ubiquitin ligase ARIH1, which is upregulated in colorectal cancer cells, promotes cell growth and metastasis and correlates with an unfavorable CRC prognosis. Mechanistically, ARIH1 catalyzes K63‐linked ubiquitination of PHB1, enhancing the interaction between PHB1 and Akt.
Ying Tong   +13 more
wiley   +1 more source

Complete mitochondrial genome of the brain coral <i>Platygyra daedalea</i> (Ellis & Solander, 1786). [PDF]

open access: yesMitochondrial DNA B Resour
Chang X   +9 more
europepmc   +1 more source

The complete mitochondrial genome of the widespread freshwater limpet <i>Ferrissia californica</i>. [PDF]

open access: yesMitochondrial DNA B Resour
Kachlishvili N   +5 more
europepmc   +1 more source

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