Results 131 to 140 of about 2,398,369 (345)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Real-time, portable genome sequencing for Ebola surveillance

Nature, 2016
The Ebola virus disease epidemic in West Africa is the largest on record, responsible for over 28,599 cases and more than 11,299 deaths. Genome sequencing in viral outbreaks is desirable to characterize the infectious agent and determine its evolutionary
J. Quick, N. Loman, S. Duraffour, J. Simpson, E. Severi, L. Cowley, J. A. Boré, Raymond Koundouno, G. Dudas, A. Mikhail, N. Ouédraogo, B. Afrough, A. Bah, J. H. Baum, B. Becker-Ziaja, J. Boettcher, Mar Cabeza-Cabrerizo, Alvaro Camino-Sanchez, Lisa L. Carter, J. Doerrbecker, T. Enkirch, Isabel Graciela García Dorival, Nicole Hetzelt, J. Hinzmann, Tobias Holm, L. Kafetzopoulou, Michel Koropogui, Abigail Kosgey, Eeva Kuisma, C. Logue, A. Mazzarelli, S. Meisel, M. Mertens, J. Michel, D. Ngabo, K. Nitzsche, Elisa Pallash, L. Patrono, J. Portmann, Johanna Repits, Natasha Y. Rickett, A. Sachse, Katrin Singethan, I. Vitoriano, Rahel L Yemanaberhan, E. Zekeng, Racine Trina, A. Bello, A. Sall, O. Faye, O. Faye, N. Magassouba, Cecelia V. Williams, Victoria Amburgey, L. Winona, E. Davis, J. Gerlach, F. Washington, V. Monteil, M. Jourdain, M. Bererd, Alimou Camara, H. Somlaré, Abdoulaye Camara, Marianne Gérard, G. Bado, Bernard Baillet, D. Delaune, K. Nebie, A. Diarra, Yacouba Savane, R. Pallawo, G. Gutierrez, N. Milhano, Isabelle Roger, Christopher J Williams, Facinet Yattara, Kuiama Lewandowski, Jamie Taylor, P. Rachwal, D. Turner, G. Pollakis, J. Hiscox, D. Matthews, M. O’Shea, A. Johnston, Duncan R. Wilson, E. Hutley, E. Smit, A. di Caro, R. Woelfel, K. Stoecker, E. Fleischmann, Martin Gabriel, S. Weller, L. Koivogui, B. Diallo, S. Keita, A. Rambaut, P. Formenty, S. Gunther, M. Carroll   +101 more
semanticscholar   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Endogenous Dionyvirus sequences are widespread in plant genomes [PDF]

, 2011
Endogenous sequences from members of the Caulimoviridae and Geminiviridae families have been identified in the genome of several plant species [1, 2].
Choisne, Nathalie, Geering, Andrew D., Quesneville, Hadi, Scalabrin, Simone, Teycheney, Pierre-Yves, Velasco, Riccardo, Vezzulli, Silvia, Zytnicki, Matthias   +7 more
core  

Single genome sequencing of near full-length HIV-1 RNA using a limiting dilution approach [PDF]

, 2019
Sequencing very long stretches of the HIV-1 genome can advance studies on virus evolution and in vivo recombination but remains technically challenging.
Demecheleer, Els, Hardy, Jarryt, Hebberecht, Laura, Mortier, Virginie, Schauvliege, Marlies, Staelens, Delfien, Vancoillie, Leen, Verhofstede, Chris   +7 more
core   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Detection of minority variants within bovine respiratory syncytial virus populations using oligonucleotide-based microarrays [PDF]

, 2008
Microarray technology, originally developed for highly parallel examination of gene expression is regarded as a potential tool in prognosis and diagnosis.
Baranowski, Eric, Deplanche, Martine, François, Jean Marie, Leberre, Véronique, Trouilh, Lidwine   +4 more
core   +3 more sources

Viral Evolution in the Genomic Age

PLoS Biology, 2007
The remarkable increase in the number of viral genome sequences represents both opportunities and challenges for understanding disease ecology and evolution, and must stimulate researchers to address questions that were previously considered out of reach.
openaire   +4 more sources

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Triple lysine and nucleosome-binding motifs of the viral IE19 protein are required for human cytomegalovirus S-phase infections

mBio
Herpesvirus genomes are maintained as extrachromosomal plasmids within the nuclei of infected cells. Some herpesviruses persist within dividing cells, putting the viral genome at risk of being lost to the cytoplasm during mitosis because karyokinesis ...
Minor R. Maliano, Kristen D. Yetming, Robert F. Kalejta   +2 more
doaj   +1 more source