Results 1 to 10 of about 3,075,076 (196)

A Genome-Wide Association Study of Neuroticism in a Population-Based Sample [PDF]

, 2010
Neuroticism is a moderately heritable personality trait considered to be a risk factor for developing major depression, anxiety disorders and dementia. We performed a genome-wide association study in 2,235 participants drawn from a population-based study
Antoniades, A, Balding, DJ, Calboli, FCF, Galwey, NW, Johnson, MR, Mooser, V, Muglia, P, Preisig, M, Tozzi, F, Vollenweider, P, Waeber, G, Waterworth, D   +11 more
core   +41 more sources

Genome-Wide Association with Select Biomarker Traits in the Framingham Heart Study [PDF]

, 2007
BACKGROUND: Systemic biomarkers provide insights into disease pathogenesis, diagnosis, and risk stratification. Many systemic biomarker concentrations are heritable phenotypes.
Benjamin, Emelia J., Booth, Sarah L., Dupuis, Josée, Govindaraju, Diddahally R., Kathiresan, Sekar, Keaney, John F., Keyes, Michelle J., Larson, Martin G., Lin, Jing-Ping, Lunetta, Kathryn L., Meigs, James B., Robins, Sander J., Rong, Jian, Schnabel, Renate, Vasan, Ramachandran S., Vita, Joseph A., Wang, Thomas J., Wilson, Peter W. F., Wolf, Philip A.   +18 more
core   +25 more sources

Genome- and Transcriptome-Wide Association Studies Identify Susceptibility Genes and Pathways for Periodontitis

Cells, 2022
Several genes associated with periodontitis have been identified through genome-wide association studies (GWAS); however, known genes only explain a minority of the estimated heritability.
Guirong Zhu, Xing Cui, Liwen Fan, Yongchu Pan, Lin Wang   +4 more
doaj   +1 more source

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

Nature Genetics, 2021
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci.
N. Mullins, A. Forstner, K. O’Connell, B. Coombes, J. Coleman, Zhen Qiao, T. Als, T. Bigdeli, S. Børte, J. Bryois, A. Charney, O. K. Drange, M. Gandal, S. Hagenaars, M. Ikeda, Nolan Kamitaki, Minsoo Kim, Kristi Krebs, Georgia Panagiotaropoulou, B. Schilder, Laura G. Sloofman, S. Steinberg, V. Trubetskoy, B. Winsvold, H. Won, L. Abramova, K. Adorjan, E. Agerbo, M. A. Al Eissa, D. Albani, N. Alliey-Rodriguez, A. Anjorin, V. Antilla, A. Antoniou, S. Awasthi, J. Baek, Marie Bækvad-Hansen, N. Bass, M. Bauer, E. Beins, Sarah E. Bergen, A. Birner, C. Bøcker Pedersen, E. Bøen, M. Boks, R. Bosch, M. Brum, B. Brumpton, N. Brunkhorst-Kanaan, M. Budde, J. Bybjerg-Grauholm, W. Byerley, M. Cairns, M. Casas, P. Cervantes, Toni‐Kim Clarke, C. Cruceanu, A. Cuellar-Barboza, J. Cunningham, D. Curtis, P. Czerski, A. Dale, N. Dalkner, F. David, F. Degenhardt, S. Djurovic, Amanda Dobbyn, A. Douzenis, T. Elvsåshagen, V. Escott-Price, I. Ferrier, A. Fiorentino, T. Foroud, L. Forty, J. Frank, O. Frei, N. Freimer, L. Frisén, K. Gade, J. Garnham, J. Gelernter, Marianne Giørtz Pedersen, I. Gizer, S. Gordon, K. Gordon-Smith, T. Greenwood, J. Grove, J. Guzmán-Parra, Kyooseob Ha, M. Haraldsson, M. Hautzinger, U. Heilbronner, D. Hellgren, S. Herms, P. Hoffmann, P. Holmans, L. Huckins, S. Jamain, Jessica S. Johnson, J. Kalman, Y. Kamatani, J. Kennedy, S. Kittel-Schneider, J. Knowles, M. Kogevinas, M. Koromina, T. Kranz, H. Kranzler, M. Kubo, R. Kupka, S. Kushner, C. Lavebratt, J. Lawrence, M. Leber, Heon-Jeong Lee, Phil H. Lee, S. Levy, Catrin E Lewis, C. Liao, S. Lucae, M. Lundberg, D. Macintyre, S. Magnusson, W. Maier, A. Maihofer, D. Malaspina, E. Maratou, Lina Martinsson, M. Mattheisen, S. Mccarroll, N. McGregor, P. McGuffin, J. Mckay, H. Medeiros, S. Medland, V. Millischer, G. Montgomery, J. Moran, D. Morris, Thomas W. Mühleisen, N. O’Brien, C. O’Donovan, Loes M. Olde Loohuis, L. Oruč, S. Papiol, A. Pardiñas, A. Perry, A. Pfennig, E. Porichi, J. Potash, D. Quested, T. Raj, M. Rapaport, J. R. DePaulo, E. J. Regeer, J. Rice, F. Rivas, M. Rivera, Julian Roth, P. Roussos, D. Ruderfer, C. Sánchez-Mora, E. Schulte, F. Senner, S. Sharp, P. Shilling, E. Sigurdsson, L. Sirignano, C. Slaney, O. Smeland, Danny J. Smith, J. Sobell, Christine Søholm Hansen, M. Soler Artigas, A. Spijker, Dan J Stein, J. Strauss, B. Świątkowska, C. Terao, T. Thorgeirsson, Claudio Toma, P. Tooney, Evangelia Eirini Tsermpini, M. Vawter, H. Vedder, J. Walters, S. Witt, S. Xi, Wei Xu, J. Yang, A. Young, Hannah Young, P. Zandi, Hang Zhou, Lea Zillich, R. Adolfsson, I. Agartz, M. Alda, L. Alfredsson, Gulja Babadjanova, L. Backlund, B. Baune, F. Bellivier, S. Bengesser, W. Berrettini, D. Blackwood, M. Boehnke, A. Børglum, G. Breen, V. Carr, S. Catts, A. Corvin, N. Craddock, U. Dannlowski, D. Dikeos, T. Esko, B. Étain, P. Ferentinos, M. Frye, J. Fullerton, M. Gawlik, E. Gershon, F. Goes, Melissa J. Green, M. Grigoroiu-Serbanescu, J. Hauser, F. Henskens, J. Hillert, K. Hong, D. Hougaard, C. Hultman, K. Hveem, N. Iwata, A. Jablensky, I. Jones, L. Jones, R. Kahn, J. Kelsoe, G. Kirov, M. Landén, M. Leboyer, C. Lewis, Qingqin S. Li, J. Lissowska, C. Lochner, C. Loughland, N. Martin, C. Mathews, F. Mayoral, S. McElroy, A. McIntosh, F. McMahon, I. Melle, P. Michie, L. Milani, P. Mitchell, G. Morken, O. Mors, P. Mortensen, B. Mowry, B. Müller-Myhsok, R. Myers, B. Neale, C. Nievergelt, M. Nordentoft, M. Nöthen, M. O’Donovan, K. Oedegaard, T. Olsson, M. Owen, S. Paciga, C. Pantelis, C. Pato, M. Pato, G. Patrinos, R. Perlis, D. Posthuma, J. Ramos-Quiroga, A. Reif, E. Reininghaus, M. Ribasés, M. Rietschel, S. Ripke, G. Rouleau, Takeo Saito, U. Schall, M. Schalling, P. Schofield, T. Schulze, L. Scott, R. Scott, A. Serretti, C. Shannon Weickert, J. Smoller, H. Stefánsson, K. Stefánsson, E. Stordal, F. Streit, P. Sullivan, G. Turecki, A. Vaaler, E. Vieta, J. Vincent, I. Waldman, T. Weickert, T. Werge, N. Wray, J. Zwart, J. Biernacka, J. Nurnberger, S. Cichon, H. Edenberg, E. Stahl, A. McQuillin, A. Di Florio, R. Ophoff, O. Andreassen   +316 more
semanticscholar   +1 more source

Identification of Druggable Genes for Asthma by Integrated Genomic Network Analysis

Biomedicines, 2022
Asthma is a common and heterogeneous disease characterized by chronic airway inflammation. Currently, the two main types of asthma medicines are inhaled corticosteroids and long-acting β2-adrenoceptor agonists (LABAs).
Wirawan Adikusuma, Wan-Hsuan Chou, Min-Rou Lin, Jafit Ting, Lalu Muhammad Irham, Dyah Aryani Perwitasari, Wei-Pin Chang, Wei-Chiao Chang   +7 more
doaj   +1 more source

The genetics of obesity: A narrative review [PDF]

Precision and Future Medicine, 2022
Monogenic obesity is a rare, early-onset, and severe form of obesity that has a Mendelian inheritance pattern, high penetrance, and large genetic effect. In contrast, common polygenic obesity is more prevalent and has pattern of heritability derived from
Young Bae Sohn
doaj   +1 more source

Replication of the Association of the 6q22.31c Locus near with Pulse Rate in the Korean Population [PDF]

Genomics & Informatics, 2012
Pulse rate is known to be related to diverse phenotypes, such as cardiovascular diseases, lifespan, arrhythmia, hypertension, lipids, diabetes, and menopause. We have reported two genomewide significant genetic loci responsible for the variation in pulse
Nam Hee Kim, Young Jin Kim, Ji Hee Oh, Yoon Shin Cho   +3 more
doaj   +1 more source

How data science and AI-based technologies impact genomics

Singapore Medical Journal, 2023
Advancements in high-throughput sequencing have yielded vast amounts of genomic data, which are studied using genome-wide association study (GWAS)/phenome-wide association study (PheWAS) methods to identify associations between the genotype and phenotype.
Jing Lin, Kee Yuan Ngiam
doaj   +1 more source

Genome-Wide Association Study on Longitudinal Change in Fasting Plasma Glucose in Korean Population [PDF]

Diabetes & Metabolism Journal, 2023
Background Genome-wide association studies (GWAS) on type 2 diabetes mellitus (T2DM) have identified more than 400 distinct genetic loci associated with diabetes and nearly 120 loci for fasting plasma glucose (FPG) and fasting insulin level to date ...
Heejin Jin, Soo Heon Kwak, Ji Won Yoon, Sanghun Lee, Kyong Soo Park, Sungho Won, Nam H. Cho   +6 more
doaj   +1 more source

rMVP: A Memory-efficient, Visualization-enhanced, and Parallel-accelerated Tool for Genome-wide Association Study

bioRxiv, 2020
Along with the development of high-throughout sequencing technologies, both sample size and number of SNPs are increasing rapidly in Genome-Wide Association Studies (GWAS) and the associated computation is more challenging than ever.
Lilin Yin, Haohao Zhang, Zhenshuang Tang, Jingya Xu, Dong Yin, Zhiwu Zhang, Xiaohui Yuan, Mengjin Zhu, Shuhong Zhao, Xinyun Li, Xiaolei Liu   +10 more
semanticscholar   +1 more source