Results 181 to 190 of about 3,091,688 (344)

A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

Nature Genetics, 2007
D. Hunter, P. Kraft, K. Jacobs, D. Cox, M. Yeager, S. Hankinson, S. Wacholder, Zhaoming Wang, R. Welch, A. Hutchinson, Junwen Wang, Kai Yu, N. Chatterjee, N. Orr, W. Willett, Graham A Colditz, R. Ziegler, C. Berg, S. Buys, C. McCarty, H. Feigelson, E. Calle, M. Thun, R. Hayes, M. Tucker, D. Gerhard, J. Fraumeni, R. Hoover, G. Thomas, S. Chanock   +29 more
semanticscholar   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Nature Genetics, 2018
R. Malik, G. Chauhan, M. Traylor, M. Sargurupremraj, Y. Okada, A. Mishra, L. Rutten-Jacobs, A. Giese, S. W. van der Laan, S. Gretarsdottir, C. Anderson, M. Chong, H. Adams, T. Ago, P. Almgren, P. Amouyel, H. Ay, T. Bartz, O. Benavente, S. Bevan, G. Boncoraglio, Robert D. Brown, A. Butterworth, C. Carrera, C. Carty, D. Chasman, Wei-Min Chen, J. Cole, A. Correa, I. Cotlarciuc, Carlos Cruchaga, J. Danesh, P. D. de Bakker, A. Destefano, M. den Hoed, Qing Duan, S. Engelter, G. Falcone, R. Gottesman, R. Grewal, V. Gudnason, S. Gustafsson, J. Haessler, T. Harris, Ahamad Hassan, A. Havulinna, S. Heckbert, E. Holliday, G. Howard, F. Hsu, Hyacinth I. Hyacinth, M. Ikram, E. Ingelsson, M. Irvin, X. Jian, J. Jiménez-Conde, Julie A. Johnson, J. Jukema, M. Kanai, Keith L. Keene, B. Kissela, D. Kleindorfer, C. Kooperberg, M. Kubo, L. Lange, C. Langefeld, C. Langenberg, L. Launer, J. Lee, R. Lemmens, D. Leys, C. Lewis, Wei-Yu Lin, A. Lindgren, E. Lorentzen, P. Magnusson, J. Maguire, A. Manichaikul, P. McArdle, J. Meschia, B. Mitchell, T. Mosley, M. Nalls, T. Ninomiya, M. O’Donnell, B. Psaty, S. Pulit, Kristiina Rannikmäe, A. Reiner, K. Rexrode, K. Rice, S. Rich, P. Ridker, N. Rost, P. Rothwell, J. Rotter, T. Rundek, R. Sacco, S. Sakaue, M. Sale, V. Salomaa, B. Sapkota, R. Schmidt, C. Schmidt, U. Schminke, Pankaj Sharma, A. Słowik, C. Sudlow, C. Tanislav, T. Tatlisumak, K. Taylor, V. Thijs, G. Thorleifsson, U. Thorsteinsdóttir, S. Tiedt, S. Trompet, C. Tzourio, C. V. van Duijn, M. Walters, N. Wareham, S. Wassertheil-Smoller, James G. Wilson, K. Wiggins, Qiong Yang, S. Yusuf, J. Bis, T. Pastinen, A. Ruusalepp, E. Schadt, Simon Koplev, J. Björkegren, Veronica Codoni, M. Civelek, N. Smith, D. Trégouët, I. Christophersen, C. Roselli, S. Lubitz, P. Ellinor, E. Tai, J. Kooner, N. Kato, Jiang He, P. van der Harst, P. Elliott, J. Chambers, F. Takeuchi, Andrew D. Johnson, D. Sanghera, O. Melander, C. Jern, D. Strbian, I. Férnandez-Cadenas, W. Longstreth, A. Rolfs, J. Hata, D. Woo, J. Rosand, G. Paré, J. Hopewell, D. Saleheen, K. Stefánsson, B. Worrall, S. Kittner, S. Seshadri, M. Fornage, H. Markus, J. Howson, Y. Kamatani, S. Debette, M. Dichgans   +170 more
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Genome-Wide Association Studies for Immunoglobulins in Colostrum and Serum in Chinese Holstein [PDF]

, 2020
Lin Shan, Cuncun Ke, Lin Liu, Yahui Gao, Lingna Xu, Bo Han, Yaofeng Zhao, Shengli Zhang, Dongxiao Sun   +8 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

KNN-MDR: a learning approach for improving interactions mapping performances in genome wide association studies [PDF]

, 2017
Sinan Abo Alchamlat, Frédéric Farnir
openalex   +1 more source

Genome-wide association study of blood pressure and hypertension

Nature Genetics, 2009
D. Levy, G. Ehret, K. Rice, G. Verwoert, L. Launer, A. Dehghan, N. Glazer, A. Morrison, Andrew D. Johnson, T. Aspelund, Y. Aulchenko, T. Lumley, A. Köttgen, R. Vasan, F. Rivadeneira, G. Eiriksdottir, Xiuqing Guo, D. Arking, G. Mitchell, F. Mattace-Raso, A. Smith, K. Taylor, R. Scharpf, Shih-Jen Hwang, E. Sijbrands, J. Bis, T. Harris, S. Ganesh, C. O’Donnell, A. Hofman, J. Rotter, J. Coresh, E. Benjamin, A. Uitterlinden, G. Heiss, C. Fox, J. Witteman, E. Boerwinkle, Thomas J. Wang, V. Gudnason, M. Larson, A. Chakravarti, B. Psaty, C. Duijn   +43 more
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source