Results 181 to 190 of about 3,155,630 (345)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis [PDF]

, 2016
Puya Gharahkhani, Rebecca C. Fitzgerald, Thomas L. Vaughan, Claire Palles, Ines Gockel, Ian Tomlinson, Matthew F. Buas, Andrea May, Christian Gerges, Mario Anders, Jessica Becker, Nicole Kreuser, Tania Noder, Marino Venerito, Lothar Veits, Thomas Schmidt, Hendrik Manner, Clemens Schmidt, Timo Hess, Anne C. Böhmer, Jakob R. Izbicki, Arnulf H. Hölscher, Hauke Lang, Dietmar Lorenz, Brigitte Schumacher, Andreas Hackelsberger, Rupert Mayershofer, Oliver Pech, Yogesh K. Vashist, Katja Ott, Michael Vieth, Josef Weismüller, Markus M. Nöthen, Stephen E. Attwood, Hugh Barr, Laura Chegwidden, John de Caestecker, Rebecca Harrison, Sharon Love, David MacDonald, Paul Moayyedi, Hans Prenen, R. G. P. Watson, Prasad G. Iyer, Lesley Anderson, Leslie Bernstein, Wong‐Ho Chow, Laura J. Hardie, Jesper Lagergren, Geoffrey Liu, Harvey A. Risch, Anna H. Wu, Weimin Ye, Nigel C. Bird, Nicholas J. Shaheen, Marilie D. Gammon, Douglas A. Corley, Carlos Caldas, Susanne Moebus, Michael Knapp, Wilbert H.M. Peters, Horst Neuhaus, Thomas Rösch, Christian Ell, Stuart MacGregor, Paul D.P. Pharoah, David C. Whiteman, Janusz Jankowski, Johannes Schumacher   +68 more
openalex   +1 more source

Genome-wide association study of blood pressure and hypertension

Nature Genetics, 2009
D. Levy, G. Ehret, K. Rice, G. Verwoert, L. Launer, A. Dehghan, N. Glazer, A. Morrison, Andrew D. Johnson, T. Aspelund, Y. Aulchenko, T. Lumley, A. Köttgen, R. Vasan, F. Rivadeneira, G. Eiriksdottir, Xiuqing Guo, D. Arking, G. Mitchell, F. Mattace-Raso, A. Smith, K. Taylor, R. Scharpf, Shih-Jen Hwang, E. Sijbrands, J. Bis, T. Harris, S. Ganesh, C. O’Donnell, A. Hofman, J. Rotter, J. Coresh, E. Benjamin, A. Uitterlinden, G. Heiss, C. Fox, J. Witteman, E. Boerwinkle, Thomas J. Wang, V. Gudnason, M. Larson, A. Chakravarti, B. Psaty, C. Duijn   +43 more
semanticscholar   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Genome-wide association study of anterior uveitis [PDF]

Fredrika Koskimäki, Oona Ahokas, Abdelrahman G. Elnahas, Anu Reigo, Kadri Reis, Tōnu Esko, Priit Palta, Sanna Leinonen, Johannes Kettunen, Johanna Liinamaa, Minna K. Karjalainen, Ville Saarela   +11 more
openalex   +1 more source

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Nature Genetics, 2013
D. Harold, R. Abraham, P. Hollingworth, R. Sims, A. Gerrish, M. Hamshere, J. S. Pahwa, V. Moskvina, Kimberley Dowzell, Amy J. Williams, N. Jones, C. Thomas, A. Stretton, A. Morgan, S. Lovestone, J. Powell, P. Proitsi, Michelle K. Lupton, C. Brayne, D. Rubinsztein, M. Gill, B. Lawlor, A. Lynch, K. Morgan, K. Brown, P. Passmore, D. Craig, B. McGuinness, S. Todd, C. Holmes, D. Mann, A. Smith, S. Love, P. Kehoe, J. Hardy, S. Mead, N. Fox, M. Rossor, J. Collinge, W. Maier, F. Jessen, B. Schürmann, R. Heun, H. Bussche, I. Heuser, J. Kornhuber, J. Wiltfang, M. Dichgans, L. Frölich, H. Hampel, M. Hüll, D. Rujescu, A. Goate, J. Kauwe, Carlos Cruchaga, P. Nowotny, J. Morris, K. Mayo, K. Sleegers, K. Bettens, S. Engelborghs, P. Deyn, C. Broeckhoven, G. Livingston, N. Bass, H. Gurling, A. McQuillin, R. Gwilliam, P. Deloukas, A. Al-Chalabi, C. Shaw, M. Tsolaki, A. Singleton, R. Guerreiro, Thomas W. Mühleisen, M. Nöthen, S. Moebus, K. Jöckel, N. Klopp, H. Wichmann, M. Carrasquillo, V. Pankratz, S. Younkin, P. Holmans, M. O’Donovan, M. Owen, Julie Williams   +86 more
semanticscholar   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Genome-Wide Association Study and Rare Variant Association Studies of Strabismus in the All of Us Research Program [PDF]

Kyoung A Lee, Corey Tesdahl, Inas F. Aboobakar, Ashish Jain, Mayra Martinez Sanchez, Kimberly Jin, Isdin Oke, Mary C. Whitman   +7 more
openalex   +1 more source

Genome-wide association study for salinity tolerance at the flowering stage in a panel of rice accessions from Thailand [PDF]

, 2019
Chakkree Lekklar, Monnat Pongpanich, Duangjai Suriya-arunroj, Aumnart Chinpongpanich, Helen Tsai, Luca Comai, Supachitra Chadchawan, Teerapong Buaboocha   +7 more
openalex   +1 more source

Common genetic determinants of vitamin D insufficiency: a genome-wide association study

The Lancet, 2010
Thomas J. Wang, Feng Zhang, J. B. Richards, B. Kestenbaum, J. V. van Meurs, D. Berry, D. Kiel, E. Streeten, C. Ohlsson, Daniel L. Koller, L. Peltonen, J. Cooper, P. O’Reilly, D. Houston, N. Glazer, L. Vandenput, M. Peacock, J. Shi, F. Rivadeneira, M. McCarthy, Pouta Anneli, I. D. de Boer, M. Mangino, B. Kato, D. Smyth, S. Booth, P. Jacques, G. Burke, M. Goodarzi, C. Cheung, M. Wolf, K. Rice, D. Goltzman, N. Hidiroglou, M. Ladouceur, N. Wareham, L. Hocking, D. Hart, N. Arden, C. Cooper, S. Malik, W. Fraser, A. Hartikainen, G. Zhai, H. Macdonald, N. Forouhi, R. Loos, D. Reid, A. Hakim, E. Dennison, Yongmei Liu, C. Power, H. Stevens, Laitinen Jaana, R. Vasan, N. Soranzo, J. Bojunga, B. Psaty, M. Lorentzon, T. Foroud, T. Harris, A. Hofman, J. Jansson, J. Cauley, A. Uitterlinden, Q. Gibson, M. Järvelin, D. Karasik, D. Siscovick, M. Econs, S. Kritchevsky, J. Florez, J. Todd, J. Dupuis, E. Hyppönen, T. Spector   +75 more
semanticscholar   +1 more source