Results 31 to 40 of about 3,091,688 (344)

Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease [PDF]

, 2011
We present the first application of the hypothesis-rich mathematical theory to genome-wide association data. The Hamza et al. late-onset sporadic Parkinson's disease genome-wide association study dataset was analyzed.
A Lerner, A Ruepp, AA Merchant, AM Glazer, B Bakir-Gungor, B Dass, C Wolff, CB Do, CH Hawkes, D Subramaniam, DAD Monte, DI Chasman, E Eskin, FL Moore, H-C Fung, HR Kim, J Simón-Sánchez, K Lai, K Roeder, K Roeder, K Roeder, K Sekimizu, K Tsuboi, L Lum, LA Hindorff, LM Bekris, M Bak, M Plaisant, M Saad, M-X Li, N Miao, O Bragina, P Mill, P Whitton, PA Beachy, PW Ingham, RE Lamont, S Purcell, SM Chambers, SY Tay, TA Manolio, TH Hamza, TL Edwards, TS Keshava Prasad, V Palma, VF Rafuse, W Satake, Y Katoh   +47 more
core   +3 more sources

Selecting Closely-Linked SNPs Based on Local Epistatic Effects for Haplotype Construction Improves Power of Association Mapping

G3: Genes, Genomes, Genetics, 2019
Genome-wide association studies (GWAS) have gained central importance for the identification of candidate loci underlying complex traits. Single nucleotide polymorphism (SNP) markers are mostly used as genetic variants for the analysis of genotype ...
Fang Liu, Renate H. Schmidt, Jochen C. Reif, Yong Jiang   +3 more
doaj   +1 more source

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

Nature Genetics, 2015
Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, with limited therapeutic options. Here we report on a study of >12 million variants, including 163,714 directly genotyped, mostly rare, protein-altering ...
F. Grassmann, Shritoma Sengupta
semanticscholar   +1 more source

Developing Novel Therapeutic Strategies Against Ring Finger Protein 213 Vasculopathy: Is It an Achievable Goal?

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
See Article Choi et ...
Minghua Liu, Jose Gutierrez
doaj   +1 more source

Genome-wide Association Study of Chicken Plumage Pigmentation [PDF]

Asian-Australasian Journal of Animal Sciences, 2013
To increase plumage color uniformity and understand the genetic background of Korean chickens, we performed a genome-wide association study of different plumage color in Korean native chickens. We analyzed 60K SNP chips on 279 chickens with GEMMA methods
Mi Na Park, Jin Ae Choi, Kyung-Tai Lee, Hyun-Jeong Lee, Bong-Hwan Choi, Heebal Kim, Tae-Hun Kim, Seoae Cho, Taeheon Lee   +8 more
doaj   +1 more source

A genome-wide association study of anorexia nervosa. [PDF]

, 2014
Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results.
A A van Elburg, A Bruson, A Farmer, A Favaro, A Hinney, A Julia, A Karwautz, A Keski-Rahkonen, A Lundervold, A Metspalu, A Palotie, A Raevuori, A Rajewski, A S Kaplan, A Scherag, A Schosser, A Slopien, A Tortorella, A Tsitsika, A Versini, Adrian Hill, Alexander P Maxwell, Anna Dominiczak, Audrey Duncanson, B Ding, B Herpertz-Dahlmann, B P C Koeleman, C Boni, C de Kovel, C Dina, C E Hilliard, C Finan, C M Bulik, C M Lewis, C S Franklin, C Taico, Carl A Anderson, Christopher S Franklin, Cordelia Langford, Cordelia Langford, Cynthia M Bulik, D A Collier, D Degortes, D Dikeos, D Koubek, D Li, D M Dick, D Martaskova, D Pinto, D Rujescu, D W Logan, David A Collier, David P Strachan, Douglas Simpkin, E Docampo, E F Van Furth, E Merl, E Strengman, E Tenconi, E Widén, E Zeggini, Eleftheria Zeggini, Emma Gray, F Fernández-Aranda, F Gonidakis, F Rybakowski, F Tozzi, Fredrik O Vannberg, G Breen, G Dedoussis, G Escaramís, G Gambaro, G Kalsi, G Komaki, G P S Knudsen, G R S Ritchie, G Wagner, Graeme Alexander, Graham Lord, H Aschauer, H Hakonarson, H Imgart, H Inoko, H Papezova, H-E Wichmann, Hannah Blackburn, I Giegling, I Jaussent, I Meulenbelt, I Ntalla, I Reinvang, I Tachmazidou, J A B Floyd, J C Barrett, J Dackor, J E DeSocio, J H Baker, J Hauser, J Hebebrand, J Hendriks, J Huemer, J I Hudson, J K O'Toole, J Kaprio, J L Kennedy, J Lissowska, J P Szatkiewicz, J Pantel, J Treasure, James A B Floyd, Jeffrey C Barrett, Jeffrey C Barrett, Jennifer Sambrook, Jonathan Stephens, K Bühren, K Egberts, K Fischer, K Kiezebrink, K L Klump, K Männik, K Tziouvas, L Alfredsson, L Carlberg, L Foretova, L Karhunen, L Klareskog, L M Huckins, L M Thornton, L Padyukov, L Peltonen, L Slachtova, L Southam, Leena Peltonen, Linda Morgan, M C T Slof-Op 't Landt, M Clementi, M de Zwaan, M Dmitrzak-Weglarz, M Forzan, M Gratacos, M J H Kas, M K Brandys, M Maj, M Mattingsdal, M Navratilova, M Roberts, Mathew Gillman, N J Schork, N Ramoz, N Soranzo, N Szeszenia-Dabrowska, N W Rayner, Neil Sheerin, Nicole Soranzo, Nicole Soranzo, null null, O A Andreassen, O S P Davis, P Courtet, P E Slagboom, P F Sullivan, P Gorwood, P Lichtenstein, P McGuffin, P Monteleone, P Santonastaso, Pamela Whittaker, Peter J Conlon, R A H Adan, R A Ophoff, R Burghardt, R D Cone, R D Levitan, R Rabionet, R Sladek, Ralph McGinnis, Richard N Sandford, S Cichon, S Cohen-Woods, S E Trace, S Ehrlich, S Gallinger, S Guillaume, S Helder, S Herms, S Jiménez-Murcia, S Le Hellard, S Marsal, S Ripatti, S Scherag, S Schreiber, S W Scherer, S Zerwas, S Zipfel, Sarah E Hunt, Sarah Edkins, Simon Potter, Stephen S Rich, Suna Onengut-Gumuscu, Susan M Ring, T Ando, T Esko, T Espeseth, T Reichborn-Kjennerud, U N Danner, U Schmidt, V Bencko, V Boraska, V Gaborieau, V Janout, V M Steen, W H Berrettini, W Herzog, Wei-Min Chen, Wendy L McArdle, Willem H Ouwehand, X Estivill, Y Guo, Z Yilmaz   +218 more
core   +2 more sources

Genetic Pathways to Insomnia

Brain Sciences, 2016
This review summarizes current research on the genetics of insomnia, as genetic contributions are thought to be important for insomnia etiology. We begin by providing an overview of genetic methods (both quantitative and measured gene), followed by a ...
Mackenzie J. Lind, Philip R. Gehrman
doaj   +1 more source

Genome-wide association study of behavioural and psychiatric features in human prion disease. [PDF]

, 2015
Prion diseases are rare neurodegenerative conditions causing highly variable clinical syndromes, which often include prominent neuropsychiatric symptoms.
Carswell, C, Collinge, J, Lowe, J, Lukic, A, MacKay, A, Mead, S, Porter, MC, Rudge, P, Thompson, AG, Uphill, J   +9 more
core   +1 more source

Genome-wide association study and meta-analysis finds over 40 loci affect risk of type 1 diabetes

Nature Genetics, 2009
Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously ...
J. Barrett, David G. Clayton, Patrick Concannon, B. Akolkar, Jason D Cooper, Henry A Erlich, Cécile Julier, Grant Morahan, Jørn Nerup, Concepcion Nierras, Vincent Plagnol, F. Pociot, Helen Schuilenburg, D. Smyth, H. Stevens, John A. Todd, N. Walker, Stephen S Rich   +17 more
semanticscholar   +1 more source

Exploring quantitative traits-associated copy number deletions through reanalysis of UK10K consortium whole genome sequencing cohorts

BMC Genomics, 2023
Objectives We performed comprehensive association analyses of common high-confidence gnomAD-reported copy number deletions (CNDs) with 60 quantitative traits from UK10K consortium WGS data.
Sejoon Lee, Jinho Kim, Jung Hun Ohn
doaj   +1 more source