Results 61 to 70 of about 1,251,540 (276)

Genome-wide analysis of insomnia disorder [PDF]

Molecular Psychiatry, 2018
Insomnia is a worldwide problem with substantial deleterious health effects. Twin studies have shown a heritable basis for various sleep-related traits, including insomnia, but robust genetic risk variants have just recently begun to be identified. We conducted genome-wide association studies (GWAS) of soldiers in the Army Study To Assess Risk and ...
Murray B. Stein, Michael J. McCarthy, Chia-Yen Chen, Sonia Jain, Joel Gelernter, Feng He, Steven G. Heeringa, Ronald C. Kessler, Matthew K. Nock, Stephan Ripke, Xiaoying Sun, Gary H. Wynn, Jordan W. Smoller, Robert J. Ursano   +13 more
openaire   +4 more sources

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Methodological Issues in Multistage Genome-Wide Association Studies [PDF]

, 2009
Because of the high cost of commercial genotyping chip technologies, many investigations have used a two-stage design for genome-wide association studies, using part of the sample for an initial discovery of ``promising'' SNPs at a less stringent ...
Casey, Graham, Conti, David V., Haile, Robert W., Lewinger, Juan Pablo, Stram, Daniel O., Thomas, Duncan C.   +5 more
core   +1 more source

Toward genome-wide SNP genotyping [PDF]

Nature Genetics, 2005
Genome-wide association studies with SNP markers are expected to allow identification of genes that underlie complex disorders. Hundreds of thousands of SNP markers will be required for comprehensive genome-wide association studies. The development of microarray-based methods for SNP genotyping on this scale remains a demanding task, despite many ...
openaire   +2 more sources

Genome-Wide Association Studies in Atherosclerosis [PDF]

Current Atherosclerosis Reports, 2011
Cardiovascular disease remains the major cause of worldwide morbidity and mortality. Its pathophysiology is complex and multifactorial. Because the phenotype of cardiovascular disease often shows a marked heritable pattern, it is likely that genetic factors play an important role.
Sivapalaratnam, S., Motazacker, M.M., Maiwald, S., Hovingh, G.K., Kastelein, J.J.P., Levi, M., Trip, M.D., Dallinga-Thie, G.M.   +7 more
openaire   +4 more sources

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Odyssey: a semi-automated pipeline for phasing, imputation, and analysis of genome-wide genetic data [PDF]

, 2019
BACKGROUND: Genome imputation, admixture resolution and genome-wide association analyses are timely and computationally intensive processes with many composite and requisite steps.
Eller, Ryan J., Janga, Sarath C., Walsh, Susan   +2 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Genome Wide Association Study of Neuropathic Ocular Pain

Ophthalmology Science
Purpose: To conduct a genome-wide association study (GWAS) of individuals with neuropathic ocular pain (NOP) symptoms to identify genomic variants that may predispose to NOP development. Design: Prospective study of individuals with NOP.
Jaxon J. Huang, BHSc, Daniel A. Rodriguez, MD, PhD, Susan H. Slifer, MSc, Eden R. Martin, PhD, Roy C. Levitt, MD, Anat Galor, MD, MSPH   +5 more
doaj   +1 more source