Results 91 to 100 of about 25,155,128 (260)
Genome-wide analysis of miRNAs in Carya cathayensis
BMC Plant Biology, 2017 Background MicroRNA (miRNA) plays an important role in plant development regulation. Hickory is an economically important plant in which the amount of flowering determines its production. Results Here, 51 conserved miRNAs, which belong to 16 families and Zhi-chao Sun, Liang-sheng Zhang, Zheng-jia Wang +2 moredoaj +1 more sourceLigand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada +5 morewiley +1 more sourceGenome-wide co-expression analysis in multiple tissues.
PLoS ONE, 2008 Expression quantitative trait loci (eQTLs) represent genetic control points of gene expression, and can be categorized as cis- and trans-acting, reflecting local and distant regulation of gene expression respectively.Ian C Grieve, Nicholas J Dickens, Michal Pravenec, Vladimir Kren, Norbert Hubner, Stuart A Cook, Timothy J Aitman, Enrico Petretto, Jonathan Mangion +8 moredoaj +1 more sourceTranslophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura +11 morewiley +1 more sourceGenome-wide significance for dense SNP and resequencing data.
, 2008 The problem of multiple testing is an important aspect of genome-wide association studies, and will become more important as marker densities increase.Whittaker, John C, De Iorio, Maria, Hoggart, Clive J, Clark, Taane G, Balding, David J +4 morecore +1 more sourceGenome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importnace of Lp(a) [PDF]
, 2012 We carried out a genome-wide association study (GWAS) of LDL-c response to statin using data from participants in the Collaborative Atorvastatin Diabetes Study (CARDS; n = 1,156), the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT; n = 895), and the ...Postmus, Iris, Colhoun, H.M., McKeigue, Paul M, Stanton, A.V., Trompet, S., Hyde, Craig, Colhoun, Helen M, Caulfield, M., Shields, Denis C., Hitman, Graham A, CARDS, Poulter, Neil, Shields, D.C., Sever, P., Chatterjee, Aurobindo, Trompet, Stella, Durrington, Paul N, Deshmukh, H.A., DeMicco, D.A., Calle, Roberto A., Hitman, Graham A., Neil, A., McKeigue, Paul M., Fuller, John H., Postmus, I., Hitman, G.A., DeMicco, David A., Johnson, T., ?, ?, Calle, Roberto A, Betteridge, D.J., Livingstone, Shona, Ford, Ian, McKeigue, P.M., Stanton, Alice V., Jukema, J.W., Johnson, Toby, Durrington, Paul N., Neil, Andrew, PROSPER Investigators, Livingstone, S., Jukema, J. Wouter, ASCOT, Colhoun, Helen, Ford, I., Sever, Peter, Fuller, J.H., Jukema, J Wouter, Caulfield, Mark, Fuller, John H, Chatterjee, A., Deshmukh, Harshal A, Calle, R.A., Hyde, C., Charlton-Menys, V., Poulter, N., Charlton-Menys, Valentine, DeMicco, David A, Betteridge, D John, McKeigue, Paul M.; id_orcid, Betteridge, D. John, Durrington, P.N., Colhoun, Helen M., Shields, Denis C, Deshmukh, Harshal A., Stanton, Alice V +65 morecore +1 more source‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...Jack P. K. Bravowiley +1 more sourceMeta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque [PDF]
, 2011 Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events.Taylor, K, Rice, K. (Kenneth), Petrovic, K. (Katja), Orru, M, Meisinger, C. (Christa), Fox, Caroline S., Ralph B D'Agostino, Ballantyne, C. (Christie), Rivadeneira Ramirez, F. (Fernando), Demissie, S, Sanna, Serena, Harris, Tamara B, Markus, Hugh S, Petrovic, KE, Huffman, J.E. (Jennifer), White, C.C. (Charles), Heiss, G. (Gerardo), Sanna, S, Eiriksdottir, Gudny, Newman, Anne B, Peltonen, L, Smith, AV, Huffman, JE, Couper, DJ, Huffman, Jennifer E., Blankenberg, Stefan, Baumert, J. (Jens), Lüdemann, Jan, Reinhold Schmidt, Arne Schillert, Sitzer, M, Dörr, M. (Marcus), Manuela Uda, Steve Bevan, Serkalem Demissie, Boerwinkle, Eric, Xia Li, O'Leary, Daniel H, Eiriksdottir, G, Ulf Schminke, O'Donnell, CJ, Wichmann, H.E. (Heinz Erich), Kavousi, M, Halperin, E, Boerwinkle, E, Illig, T. (Thomas), Heiss, G, Heckbert, Susan R, Bis, JC, Tamara B Harris, Harris, T.B. (Tamara), Smith, Albert V, Launer, Lenore J, Ziegler, A, Schmidt, Reinhold, Heckbert, Susan R., Meisinger, Christa, Wild, P.S. (Philipp), Polak, Joseph F., Klopp, Norman, Cupples, L.A. (Adrienne), Joseph F Polak, Aspelund, T. (Thor), Wolf, PA, Couper, David J., Alan R Shuldiner, White, Charles C, Rivadeneira, F, Homuth, G, Gonçalo R Abecasis, Cheng, YC, Maryam Kavousi, Taylor, Kent, White, CC, Li, X. (Xia), ?, ?, Orru, Marco, Wild, PS, Bevan, S, Duijn, Cornelia, Wendy S Post, Abbas Dehghan, Halperin, E. (Eran), Luedemann, Jan, Smith, A.V. (Albert Vernon), Münzel, T, Franceschini, N. (Nora), Kähönen, M, Stoegerer, EM, Baumert, Jens, Reilly, Muredach P., Thomas Illig, Völzke, H. (Henry), Homuth, G. (Georg), D'Agostino, RB, Lenore J Launer, Schminke, Ulf, Christie Ballantyne, Franceschini, N, Uda, Manuela, Wild, Philipp S, Scuteri, Angelo, Huffman, Jennifer E, Rice, Kenneth, Hugh S Markus, Christopher J O'Donnell, Launer, Lenore J., Usala, G, Fernando Rivadeneira, Jacqueline Witteman, Post, WS, Norman Klopp, Gudnason, V. (Vilmundur), Petrovic, Katja E., Mitchell, BD, Uitterlinden, Andre, Post, W.S. (Wendy S.), Wolf, Philip A, Reilly, M.P. (Muredach), Rotter, Jerome I, Franceschini, Nora, Newman, Anne B., Andreas Ziegler, Marco Orru, Uitterlinden, A, Fox, CS, Dörr, Marcus, Schnabel, R.B. (Renate), Edward G Lakatta, Nambi, Vijay, Isaacs, Aaron; id_orcid, Cheng, Yu-Ching, Uitterlinden, A.G. (André), Ben Oostra, Wilson, James F, Stefan Blankenberg, Schmidt, Helena, O'Donnell, C.J. (Christopher), Koenig, W, Völzke, H, Reilly, MP, Thomas Münzel, Mika Kähönen, Dehghan, Abbas, Gudnason, V, Bevan, Steve, Raitakari, O, Thorsson, Bolli, Yu-Ching Cheng, Isaacs, A.J. (Aaron), Caroline S Fox, Koenig, Wolfgang, Albert V Smith, Cupples, LA, Rathmann, W, Bruce M Psaty, Andre Uitterlinden, Zeller, T, Smith, Albert V., Shuldiner, Alan R, Florian Ernst, Ballantyne, C, Kavousi, M. (Maryam), Chilukoti, R.K. (Ravi Kumar), Ziegler, Andreas, Duijn, CV, Schillert, A, Lakatta, Edward G., Psaty, B.M. (Bruce), Homuth, Georg, Harris, TB, O'Leary, D.H. (Daniel H.), Ernst, Florian, Raitakari, Olli, Post, Wendy S, Shuldiner, AR, Demissie, S. (Serkalem), Abecasis, GR, Oostra, B.A. (Ben), Schnabel, RB, Joshua C Bis, Wilson, James F., Kathiresan, S. (Sekar), Gerardo Heiss, Thor Aspelund, Hofman, Albert, Eric Boerwinkle, Illig, Thomas, Mitchell, B.D. (Braxton), Schillert, Arne, Hayward, C, Voelzke, Henry, North, K, Polak, Joseph F, Polak, JF, Halperin, Eran, Lehtimäki, T. (Terho), Tanja Zeller, Lakatta, E. (Edward), Joachim Thiery, Helena Schmidt, David J Couper, Aaron Isaacs, Demissie, Serkalem, Rotter, JI, Seissler, J. (Jochen), Petrovic, Katja E, Chilukoti, Ravi Kumar, Duijn, C.M. (Cornelia) van, Thiery, Joachim, Thorsson, B. (Bolli), Schillert, A. (Arne), Psaty, Bruce M., Mitchell, Braxton D., Henry Völzke, Kenneth Rice, Lüdemann, J, Lehtimaki, Terho, Isaacs, A, Marcus Dörr, Matthias Sitzer, Witteman, Jacqueline, Uda, M. (Manuela), Bis, Joshua C, Lehtimäki, T, Shuldiner, A.R. (Alan), Bevan, S. (Steve), null null, Serena Sanna, H Erich Wichmann, Lakatta, EG, Abecasis, G.R. (Gonçalo), Parsa, Afshin, Bis, J.C. (Joshua), Uda, M, Wichmann, H Erich, Blankenberg, S. (Stefan), Shuldiner, Alan R., Anne B Newman, Hofman, Bert, North, Kari, Thiery, J.P. (Joachim), Dörr, M, Afshin Parsa, Vijay Nambi, Zeller, Tanja, Schminke, U. (Ulf), Chilukoti, RK, Leena Peltonen, Rotter, J.I. (Jerome), Psaty, Bruce M, Heckbert, SR, Dehghan, A, Nambi, V, Witteman, J, Polak, J.F. (Joseph F.), Jorma Viikari, Kari North, Eran Halperin, Daniel H O'Leary, Wolf, Philip A., Seissler, Jochen, Usala, G., O'Leary, DH, Heckbert, S.R. (Susan), Ballantyne, Christie, Nora Franceschini, North, K.E. (Kari), Jennifer E Huffman, Jan Lüdemann, Vilmundur Gudnason, Meisinger, C, Jens Baumert, Rivadeneira, Fernando, Ziegler, A. (Andreas), O'Donnell, Christopher J., Eiriksdottir, G. (Gudny), Kathiresan, S, Wolf, P.A. (Philip), Cheng, Y.C. (Yu Ching), van Duijn, Cornelia, Rathmann, Wolfgang, Wolfgang Koenig, Zeller, T. (Tanja), Peltonen, Leena, Kent Taylor, Kähönen, M. (Mika), D'Agostino, Ralph B, Olli Raitakari, Völzke, Henry, Ernst, F, Mitchell, Braxton D, Wichmann, HE, Heiss, Gerardo, Muenzel, Thomas, Abecasis, Goncalo R., Koenig, W. (Wolfgang), James F Wilson, Viikari, J. (Jorma), Wilson, James F; id_orcid, Boerwinkle, E.A. (Eric), Susan R Heckbert, Markus, HS, Seissler, J, Bis, Joshua C., O'Leary, Daniel H., Klopp, N, Ravi Kumar Chilukoti, Stoegerer, E.M. (Eva Maria), Usala, Gianluca, Fox, C.S. (Caroline), Caroline Hayward, Harris, Tamara B., Li, X, Parsa, A, Jochen Seissler, Abecasis, Gonçalo R, Illig, T, Jerome I Rotter, Cupples, L Adrienne, Cupples, L. Adrienne, Launer, LJ (Lenore), Gudnason, Vilmundur, Lakatta, Edward G, Schmidt, R, Scuteri, A, Bolli Thorsson, Stoegerer, Eva-Maria, Uitterlinden, André; id_orcid, Post, Wendy S., Schmidt, R. (Reinhold), Schmidt, H, Kahonen, Mika, Cornelia van Duijn, Angelo Scuteri, Philipp S Wild, Viikari, J, Schnabel, Renate B, Baumert, J, Peltonen, L. (Leena Johanna), Renate B Schnabel, Sekar Kathiresan, Muredach P Reilly, D'Agostino, Ralph Sr., Rice, K, Philip A Wolf, Parsa, A. (Afshin), Doerr, Marcus, Orrù, M. (Marco), White, Charles C., Dehghan, A. (Abbas), Hayward, Caroline, Hofman, A. (Albert), Münzel, Thomas, Witteman, JCM, Blankenberg, S, Albert Hofman, Schnabel, Renate B., O'Donnell, Christopher J, D'Agostino, Ralph B., Sr., Sitzer, Matthias, CARDIoGRAM Consortium, Katja E Petrovic, Viikari, Jorma, Oostra, B, Ernst, F.D.J. (Florian), Aspelund, T, Rathmann, W. (Wolfgang), D'Agostino, R.B. (Ralph), Couper, D.J. (David), Couper, David J, Thorsson, B, Psaty, BM, Wolfgang Rathmann, Hayward, C. (Caroline), Oostra, Ben, Aspelund, Thor, Reilly, Muredach P, Georg Homuth, Markus, H.S. (Hugh S.), Lüdemann, J. (Jan), Gianluca Usala, Taylor, K.D. (Kent), Isaacs, Aaron, Wichmann, H. Erich, Raitakari, O. (Olli), Hofman, A, Kathiresan, Sekar, Wilson, JF, Launer, L.J. (Lenore), Markus, Hugh S., Schminke, U, Charles C White, Launer, LJ, Thiery, J, Sanna, S. (Serena), Duijn, Cornelia van, Newman, AB, Newman, A.B. (Anne), Christa Meisinger, Witteman, J.C.M. (Jacqueline), Klopp, N. (Norman), Wild, Philipp S., Wilson, J.F. (James), Eva-Maria Stoegerer, Hayward, Caroline; id_orcid, Kavousi, Maryam, Nambi, V. (Vijay), Sitzer, M. (Matthias), Rotter, Jerome I., Münzel, T. (Thomas), Gudny Eiriksdottir, Braxton D Mitchell, L Adrienne Cupples, Terho Lehtimäki, Li, Xia, Scuteri, A. (Angelo), Fox, Caroline S +417 morecore +1 more source
