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A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci [PDF]
, 2010 We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which ...Taylor JA, Diver WR, Vermeulen, Sita H, Xifeng Wu, Allione A, Hildebrandt, MA, Hengstler JG, Besenbacher, S, Godfrey, A., Trichopoulos D, Tjonneland A, Teo MT, Nuria Malats, Koppova, Kvetoslava, Panico, S, Malcolm C Pike, Albanes, D, Prokunina-Olsson, L, Riboli, E., Baris, D, Yeager, M, Dietrich, H., Kiltie, Anne, Xu, Z, Kiemeney L, Benhamou, Simone, Allen, Naomi E, Vineis P, Fletcher T, Yuan J, Knowles, M.A., Silverman, DT, Taylor, JA, Alan Schned, Bishop, DT, Manolis Kogevinas, Mark T W Teo, Xu Z, Lloreta, J., Hutchinson A, Sanz-Velez JI, Colin P Dinney, Wheeler, William, Francisco X Real, Fletcher, T, Godfrey, Ashley, Valdivia G, Matullo, Giuseppe, Fraumeni, Joseph F, Klaus Golka, Cancel-Tassin, Geraldine, Czerniak, B., Stefansson, K, Peter Rudnai, Federico Canzian, Czerniak, Bogdan, Thun M, McGrath, Monica, Gago-Dominguez, M., Clavel-Chapelon, F, Sanchez, Manuel, Gago-Dominguez, M, Panico S, Sulem P, Chanock, Stephen J, McGrath M, Lloreta, Josep, 1958-, Mayordomo, Jose I, Dinney, Colin P, Vineis, Paolo, Ljungberg, Borje, Weinstein, SJ, Real, FX, Chatterjee N, Olivier Cussenot, H Bas Bueno-de-Mesquita, Kumar, Rajiv, Xu, Z., Tony Fletcher, Hushan Yang, Bueno-De-Mesquita, HB, Hildebrandt, M.A.T., Rothman N, Chen, Meng, Naomi E Allen, Jacobs EJ, Albanes, Demetrius, Karagas, MR, Margaret A Knowles, Mayordomo JI, Kiemeney LA, Dinney, CP, Gurzau, Eugen, Riboli, E, Riboli, Elio, Dinney CP, Chen M, Grubb R. 3rd, Baris, D., Consol Serra, Borje Ljungberg, Garcia-Closas, M., Hengstler, JG, Polidoro, S., Geraldine Cancel-Tassin, Cussenot, O, Caporaso, N., Pike, MC, Johnson, A, Real, F.X., Teo, MTW, McGrath, M., Sacerdote C, Kogevinas, M., Maria Teresa Landi, Landi, M.T., Canzian, F, Makkinje RR, Tardon, A., Johnson A, Caporaso, Neil, Stern, M.C., Cancel Tassin G, Jan G Hengstler, Caporaso N, Fulvio Ricceri, Vermeulen SH, Clavel-Chapelon, F., Lloreta J, Allen, NE, Koppova, K., Navarro, Carmen, Xu, ZL, Gapstur, SM, Schwenn, Molly, Karagas MR, Robert Grubb, Ljungberg, B, Allen NE, Sanz Velez JI, Serra, Consol, Godfrey, A, Polidoro, Silvia, Hunter, David J, María D García-Prats, Selinski, S., De Vivo, I., Prokunina Olsson L, Fu, YP, Virtamo, J., Schned, Alan, Alessandra Allione, José I Sanz-Velez, J Alfred Witjes, Garcia-Closas, R., Giuseppe Matullo, Teo, MT, Golka K, Adonina Tardón, Sanchez M, Chen, M., Van Den Berg, D, Chatterjee, N, Clavel Chapelon F, Bolick, S.C., Yang, H, Fu, Y., Mariana C Stern, Diver, W.R., Andriole, Gerald, Pike, Malcolm C, Rudnai, P, Yi-Ping Fu, Diver, W Ryan, Hunter, DJ, Grubb R 3rd, Margaret R Karagas, De Vivo, Immaculata, Kvetoslava Koppova, Besenbacher, S., Cortessis, Victoria K, Grubb R, Tjonneland, A., Stern, Mariana C, Carmen Navarro, Burdett, L., Anne Tjonneland, Andriole, G, Jacobs KB, Canzian, Federico, Fu Y, Elio Riboli, Laurie Burdett, Hengstler, Jan G, Serra, C, Karagas, Margaret R, De Vivo, I, Gapstur SM, Tardón García, Adonina, Czerniak B, Black, A, Wu, X, Baris, Dalsu, Guarrera, S, Eric J Jacobs, Teo, Mark T W, D García-Prats M, Eugen Gurzau, Taylor, Jack A, Yuan JM, Gago Dominguez M, Knowles MA, Golka, Klaus, Valdivia, Gabriel, Francoise Clavel-Chapelon, Guarrera, Simonetta, Michael Thun, Black A, García Closas R, Kiltie, Anne E, Fraumeni, JF, Benhamou, S, Lloreta, J, Besenbacher, Soren, Bolick, Sophia C E, McGrath, M, Ashley Godfrey, D García-Prats, María, Bolick, SCE, Kiltie, A.E., Kiltie AE, MA Hildebrandt, Dimitrios Trichopoulos, Cussenot, O., Wu, XF, Cancel-Tassin G, Rothman, Nathaniel, Hildebrandt MA, Rafnar, T, Trichopoulos, D., Brennan P, Virtamo J, Robert N Hoover, Purdue, Mark P, Grubb, R, Polidoro, S, Ricceri, F, Thun, M, Allen, N.E., Chanock, SJ, Allione, A., Yeager, Meredith, Thun, Michael, Porru S, Sanz-Velez, JI, Wu, X., Xu, Zongli, Jack A Taylor, Manuela Gago-Dominguez, Garcia-Closas, Montserrat, Debra T Silverman, Chatterjee, N., Monica McGrath, Koppova, K, Alison Johnson, Meng Chen, Makkinje, Remco R, Purdue, MP, Caporaso, N, Fraumeni JF Jr, Paul Brennan, Patrick Sulem, Chen, M, Brennan, P, Real FX, Trichopoulos, Dimitrios, Virtamo, Jarmo, Jacobs, E.J., Koppova K, Hildebrandt, MAT, De Vivo I, Allione, Alessandra, Purdue, M., Andriole G. Jr, Godfrey A, Brennan, Paul, Tjonneland, A, Schwenn, M, Vineis, P, Montserrat Garcia-Closas, Kiemeney, LA, Silverman, Debra T, Pike, M.C., Rajiv Kumar, Kevin B Jacobs, Schned, A., Sulem, P., Kiemeney, L.A.L.M., Sacerdote, C., Garcia Closas M, Canzian, F., Polidoro S, Zongli Xu, Hengstler, J.G., Jacobs, K.B., Baris D, Jacobs, EJ, Yang, HS, Wang, Z., Sophia C E Bolick, Black, A., Makkinje, R.R., García Closas, Montserrat, Trichopoulos, D, Katja K Aben, Berg, D.P.G. van den, Albanes, D., Jacobs, Eric J, Landi MT, Gurzau E, Kogevinas, M, Sacerdote, Carlotta, Porru, Stefano, Guarrera, S., Wang, Zhaoming, Rudnai P, Ljungberg, Börje,, Panico, Salvatore, Yang, H., Josep Lloreta, Hunter, D.J., Matullo G, Wheeler, W, Virtamo, J, Burdett, Laurie, Figueroa JD, Garcia-Prats, MD, Silverman DT, Tardón A, Jonine D Figueroa, Rafnar T, David J Hunter, Aben, K.K.H., Hoover, RN, Wang, Z, Wang, ZW, W Ryan Diver, Lloreta, Josep, Knowles, Margaret A, Wheeler, W., Prokunina-Olsson, L., D García-Prats, M, Landi, Maria Teresa, Kari Stefansson, Stephen J Chanock, Valdivia, G, Hildebrandt, Michelle AT, Bishop, David T, Joseph F Fraumeni, Figueroa, J.D., Garcia-Closas M, Ricceri, F., Immaculata De Vivo, Remco R Makkinje, Bueno de Mesquita HB, Malats, Nuria, Silvia Polidoro, Sulem, P, Pike MC, Cortessis, VK, Mayordomo, JI, Chanock, Stephen J., Mark P Purdue, Weinstein, Stephanie J, Thun, M., Hutchinson, A., Panico, S., Simone Benhamou, Chanock SJ, Bolick, SC, Bolick SC, Amanda Black, Tardon, A, Andriole G Jr, Dalsu Baris, Brennan, P., Allione, A, Hoover, Robert N, Fraumeni JF, Jian-Min Yuan, Meredith Yeager, Yeager, M., Karagas, M.R., Jose I Mayordomo, Landi, MT, Clavel-Chapelon F, Hunter DJ, Real, Francisco X, Matullo, G, Weinstein SJ, Soren Besenbacher, Hoover RN, Selinski, S, Hutchinson, A, Besenbacher S, Navarro C, Makkinje, RR, Cortessis, V.K., Rothman, N, Porru, S, Ludmila Prokunina-Olsson, Burdett, L, Andriole, G.L., Andriole G, Sacerdote, C, Malats, N., Figueroa, Jonine D, Sulem, Patrick, Prokunina-Olsson L, Anne E Kiltie, Ricceri F, Cussenot, Olivier, Stern, MC, Michelle A T Hildebrandt, Matullo, G., Johnson, A., Nilanjan Chatterjee, Kumar, R, CAPORASO, NICOLA, Tjonneland, Anne, Taylor, J.A., Kiltie, AE, Sita H Vermeulen, Demetrius Albanes, Real, Francisco X., William Wheeler, Gapstur, Susan M, Cortessis VK, Vilneis, P., Dietrich, Holger, Schwenn M, Jarmo Virtamo, Rafnar, Thorunn, Figueroa, JD, Vermeulen, SH, Bueno-de-Mesquita, H Bas, Guarrera S, Jacobs, Kevin B, Dietrich H, Cancel-Tassin, G, Dinney, C.P., Stefansson, Kari, Ricceri, Fulvio, Prokunina-Olsson, Ludmila, Serra, C., Chatterjee, Nilanjan, Grubb, R., Molly Schwenn, Vermeulen, S., Canzian F, García Prats MD, Cussenot O, Carlotta Sacerdote, Bolick, Sophia CE, Zhaoming Wang, Weinstein, S.J., Manuel Sanchez, Schwenn, M., Van Den Berg D, Hildebrandt, Michelle A T, Stern MC, Wheeler W, Clavel-Chapelon, Francoise, Rudnai, Peter, Malats N, Dietrich, H, Grubb, Robert, Bueno-De-Mesquita, H.B., Riboli E, Wu, Xifeng, Cancel-Tassin, G., Kogevinas M, Witjes, JA, Stefano Porru, Garcia-Closas, M, Gago-Dominguez M, Witjes, J Alfred, Purdue MP, Nathaniel Rothman, Simonetta Guarrera, Rafnar, T., Bishop, D.T., Garcia-Closas, R, Diver, WR, Albanes D, Fletcher, Tony, Gabriel Valdivia, Kiemeney, Lambertus A, Stefansson K, Susan M Gapstur, Aben, Katja K, Bishop DT, Yuan, JM, Victoria K Cortessis, Kogevinas, Manolis, Kumar R, Amy Hutchinson, Lambertus A Kiemeney, Bueno-de-Mesquita HB, Benhamou S, Yeager M, Witjes JA, Carrato, Alfredo, Gago-Dominguez, Manuela, Teo, M.T., Neil Caporaso, Wang Z, Ljungberg B, Wu X, Yang H, Gurzau, E, Yuan, Jian-Min, Schned, A, Serra C, Navarro, C, Reina García-Closas, Holger Dietrich, Golka, K., David T Bishop, Burdett L, Salvatore Panico, Aben, KK, Sanchez, M, Witjes, J.A., Yang, Hushan, D. García Prats M, Gapstur, S.M., Czerniak, B, Selinski, Silvia, Schned A, Silvia Selinski, Yuan, J.M., Stephanie J Weinstein, Sanz-Velez, José I, Carrato, A., Malats, N, Fu, Yi-Ping, Den Berg DV, Hutchinson, Amy, García-Closas R, Vivo ID, Knowles, MA, Thorunn Rafnar, Alfredo Carrato, Carrato, A, Johnson, Alison, Bogdan Czerniak, Gerald Andriole, Teo, Mark TW, Aben KK, Carrato A, Jacobs, KB, Mayordomo, J.I., Fletcher, T., Rudnai, P., Fu YP, Kumar, R., Paolo Vineis, Selinski S, Golka, K, David Van Den Berg, Black, Amanda, Jacobs, Eric J., Vermeulen, Sita H., Lloreta Trull, Josep, 1958-, Karagas, Margaret R., Mayordomo, Jose I., Kiltie, Anne E., Cortessis, Victoria K., Bishop, David T., Kiemeney, Lambertus A., Garcia-Closas, Reina, Stern, Mariana C., Hengstler, Jan G., Aben, Katja K., Makkinje, Remco R., Diver, W. Ryan, Witjes, J. Alfred, Silverman, Debra T., Figueroa, Jonine D., Bueno-de-Mesquita, H. Bas, Gapstur, Susan M., Sanz-Velez, Jose I., Bolick, Sophia C. E., Jacobs, Kevin B., Purdue, Mark P., Garcia-Prats, Maria D., Hunter, David J., Teo, Mark T. W., Weinstein, Stephanie J., Andriole, Gerald, Jr., Hildebrandt, Michelle A. T., Van den Berg, David, Allen, Naomi E., Taylor, Jack A., Dinney, Colin P., Fraumeni, Joseph F., Jr., Tardon, Adonina, Hoover, Robert N., Knowles, Margaret A., Grubb, Robert, III, Pike, Malcolm C. +611 morecore +2 more sourcesGenome-wide SNP analysis of Japanese Thoroughbred racehorses.
PLoS ONE, 2019 The domestication process of plants and animals typically involves intense inbreeding and directional selection for various traits. Here, we genotyped 370 Japanese Thoroughbred horses using the recently developed 670k SNP array and performed various ...Jeffrey A Fawcett, Fumio Sato, Takahiro Sakamoto, Watal M Iwasaki, Teruaki Tozaki, Hideki Innan +5 moredoaj +1 more sourceIMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd +9 morewiley +1 more sourceDifferential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales +11 morewiley +1 more sourceKDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan +16 morewiley +1 more sourceDevelopmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley +13 morewiley +1 more sourceUSP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra +16 morewiley +1 more sourceFinding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer +10 morewiley +1 more source
