Results 1 to 10 of about 669,302 (196)

Status and prospects of genome‐wide association studies in plants

The Plant Genome, 2021
Genome‐wide association studies (GWAS) have developed into a powerful and ubiquitous tool for the investigation of complex traits. In large part, this was fueled by advances in genomic technology, enabling us to examine genome‐wide genetic variants ...
Laura Tibbs Cortes, Zhiwu Zhang, Jianming Yu   +2 more
doaj   +2 more sources

Chapter 11: Genome-wide association studies.

PLoS Computational Biology, 2012
Genome-wide association studies (GWAS) have evolved over the last ten years into a powerful tool for investigating the genetic architecture of human disease.
William S Bush, Jason H Moore
doaj   +2 more sources

Genome-Wide Association Study on Longitudinal Change in Fasting Plasma Glucose in Korean Population [PDF]

Diabetes & Metabolism Journal, 2023
Background Genome-wide association studies (GWAS) on type 2 diabetes mellitus (T2DM) have identified more than 400 distinct genetic loci associated with diabetes and nearly 120 loci for fasting plasma glucose (FPG) and fasting insulin level to date ...
Heejin Jin, Soo Heon Kwak, Ji Won Yoon, Sanghun Lee, Kyong Soo Park, Sungho Won, Nam H. Cho   +6 more
doaj   +1 more source

Genome-Wide Association Study Identifies Loci Associated with Sensitive Skin

Cosmetics, 2020
Individuals suffering from sensitive skin often have other skin conditions and/or diseases, such as fair skin, freckles, rosacea, or atopic dermatitis. Genome-wide association studies (GWAS) have been performed for some of these conditions, but not for ...
Miranda A. Farage, Yunxuan Jiang, Jay P. Tiesman, Pierre Fontanillas, Rosemarie Osborne   +4 more
doaj   +1 more source

Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative

Genome Medicine, 2022
Background Large medical centers in urban areas, like Los Angeles, care for a diverse patient population and offer the potential to study the interplay between genetic ancestry and social determinants of health.
Ruth Johnson, Yi Ding, Vidhya Venkateswaran, Arjun Bhattacharya, Kristin Boulier, Alec Chiu, Sergey Knyazev, Tommer Schwarz, Malika Freund, Lingyu Zhan, Kathryn S. Burch, Christa Caggiano, Brian Hill, Nadav Rakocz, Brunilda Balliu, Christopher T. Denny, Jae Hoon Sul, Noah Zaitlen, Valerie A. Arboleda, Eran Halperin, Sriram Sankararaman, Manish J. Butte, UCLA Precision Health Data Discovery Repository Working Group, UCLA Precision Health ATLAS Working Group, Clara Lajonchere, Daniel H. Geschwind, Bogdan Pasaniuc   +25 more
doaj   +1 more source

H3AGWAS: a portable workflow for genome wide association studies

BMC Bioinformatics, 2022
Background Genome-wide association studies (GWAS) are a powerful method to detect associations between variants and phenotypes. A GWAS requires several complex computations with large data sets, and many steps may need to be repeated with varying ...
Jean-Tristan Brandenburg, Lindsay Clark, Gerrit Botha, Sumir Panji, Shakuntala Baichoo, Christopher Fields, Scott Hazelhurst   +6 more
doaj   +1 more source

A concise history of genome-wide association studies

Saudi Journal of Medicine and Medical Sciences, 2013
Genome-wide association studies (GWASs) have had a tremendous impact on the pace of genomic research of common diseases. The number of identified genetic variants associated has grown exponentially. For some diseases, such as coronary heart disease (CHD),
Bobby P. C. Koeleman, Amein Al-Ali, Sander W van der Laan, Folkert W Asselbergs   +3 more
doaj   +1 more source

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

Nucleic Acids Res., 2018
The GWAS Catalog delivers a high-quality curated collection of all published genome-wide association studies enabling investigations to identify causal variants, understand disease mechanisms, and establish targets for novel therapies.
A. Buniello, J. MacArthur, M. Cerezo, Laura W. Harris, J. Hayhurst, Cinzia Malangone, A. McMahon, Joannella Morales, Edward Mountjoy, E. Sollis, D. Suveges, Olga Vrousgou, P. Whetzel, R. Amode, Jose A. Guillen, H. Riat, S. Trevanion, Peggy Hall, Heather Junkins, P. Flicek, Tony Burdett, L. Hindorff, Fiona Cunningham, H. Parkinson   +23 more
semanticscholar   +1 more source

Robust Gene-Gene Interaction Analysis in Genome Wide Association Studies. [PDF]

PLoS ONE, 2015
Genome-wide association studies (GWAS) have successfully discovered hundreds of associations between genetic variants and complex traits. Most GWAS have focused on the identification of single variants.
Yongkang Kim, Taesung Park
doaj   +1 more source

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

PLoS Genetics, 2009
Genotype imputation methods are now being widely used in the analysis of genome-wide association studies. Most imputation analyses to date have used the HapMap as a reference dataset, but new reference panels (such as controls genotyped on multiple SNP ...
Bryan N. Howie, P. Donnelly, J. Marchini
semanticscholar   +1 more source