Results 151 to 160 of about 669,401 (295)
Genome-Wide Association Study Reveals Additive and Non-Additive Effects on Growth Traits in Duroc Pigs [PDF]
, 2022 Yahui Xue, Shen Liu, Weining Li, Ruihan Mao, Yue Zhuo, Wenkai Xing, Jian Liu, Chuang Wang, Lei Zhou, Minggang Lei, Jianfeng Liu +10 moreopenalex +1 more sourceMonitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien +35 morewiley +1 more sourceLINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico +12 morewiley +1 more sourceGenome-Wide Association Study and Transcriptome Analysis Identify QTL and Candidate Genes Involved in Nitrogen Response Mechanisms in Sorghum [PDF]
Fangfang Fan, Yao Wang, Xiaoqiang Cheng, Jun Wang, Yubin Wang, Lan Ju, Haisheng Yan, Hao Niu, Xin Lv, Jianqiang Chu, Junai Ping, Xiaoyan Jiao +11 moreopenalex +1 more sourceATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs +11 morewiley +1 more sourceIdentification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
Lancet Neurology, 2019 M. Nalls, C. Blauwendraat, C. Vallerga, K. Heilbron, S. Bandres-Ciga, Diana Chang, M. Tan, D. Kia, A. Noyce, Angli Xue, J. Bras, Emily Young, R. Coelln, J. Simón-Sánchez, C. Schulte, Manu Sharma, L. Krohn, L. Pihlstrøm, A. Siitonen, H. Iwaki, H. Leonard, F. Faghri, J. R. Gibbs, D. Hernandez, Sonja W. Scholz, J. Botía, Maria Martinez, J. Corvol, S. Lesage, J. Jankovic, L. Shulman, Margaret Sutherland, P. Tienari, K. Majamaa, M. Toft, O. Andreassen, Tushar Bangale, A. Brice, Jian Yang, Z. Gan-Or, T. Gasser, P. Heutink, J. Shulman, N. Wood, D. Hinds, J. Hardy, H. Morris, J. Gratten, P. Visscher, R. Graham, A. Singleton, A. Adarmes-Gómez, M. Aguilar, A. Aitkulova, V. Akhmetzhanov, R. Alcalay, I. Álvarez, V. Álvarez, F. Barrero, J. A. B. Yarza, I. Bernal‐Bernal, Kimberley J. Billingsley, M. Blázquez, Marta Bonilla‐Toribio, J. Botía, M. Boungiorno, K. Brockmann, V. Bubb, D. Buiza‐Rueda, A. Cámara, F. Carrillo, M. Carrión-Claro, D. Cerdán, V. Chelban, J. Clarimón, C. Clarke, Y. Compta, M. Cookson, D. Craig, F. Danjou, M. Diez-Fairen, O. Dols-Icardo, J. Duarte, R. Durán, F. Escamilla-Sevilla, V. Escott-Price, M. Ezquerra, C. Feliz, M. Fernández, R. Fernández-Santiago, S. Finkbeiner, T. Foltynie, C. García, P. Garcia-Ruiz, M. G. Heredia, P. Gómez-Garre, M. González, I. González‐Aramburu, S. Guelfi, R. Guerreiro, J. Hardy, S. Hassin-Baer, J. Hoenicka, P. Holmans, H. Houlden, J. Infante, S. Jesús, A. Jiménez-Escrig, Gulnaz Kaishybayeva, R. Kaiyrzhanov, A. Karimova, K. J. Kinghorn, S. Kõks, J. Kulisevsky, M. Labrador-Espinosa, H. Leonard, P. Lewis, J. López-Sendón, R. Lovering, S. Lubbe, C. Lungu, D. Macias, C. Manzoni, J. Marín, J. Marinus, M. Marti, I. M. Torres, J. Martínez-Castrillo, M. Mata, N. Mencacci, C. Méndez-del-Barrio, B. Middlehurst, A. Mínguez, P. Mir, K. Mok, E. Muñoz, Derek P. Narendra, O. Ojo, N. Okubadejo, A. Pagola, P. Pastor, F. Errazquin, T. Periñán-Tocino, L. Pihlstrøm, H. Plun-Favreau, J. Quinn, L. R'bibo, X. Reed, E. Rezola, M. Rizig, P. Rizzu, L. Robak, Antonio Sanchez Rodriguez, G. Rouleau, J. Ruiz‐Martinez, C. Ruz, M. Ryten, D. Sadykova, S. Schreglmann, C. Shashkin, M. Sierra, E. Suárez-Sanmartin, P. Taba, C. Tabernero, Manuela Tan, J. P. Tartari, C. Tejera-Parrado, E. Tolosa, D. Trabzuni, F. Valldeoriola, J. V. Hilten, K. Keuren-Jensen, L. Vargas‐González, L. Vela, F. Vives, N. Williams, N. Zharkinbekova, Zharkyn Zharmukhanov, Elena Zholdybayeva, A. Zimprich, P. Ylikotila, L. Shulman, S. Reich, J. Savitt, M. Agee, B. Alipanahi, A. Auton, R. Bell, K. Bryc, S. Elson, P. Fontanillas, N. Furlotte, K. Huber, B. Hicks, E. Jewett, Yunxuan Jiang, A. Kleinman, Keng-Han Lin, N. Litterman, J. McCreight, M. Mcintyre, K. McManus, J. Mountain, E. Noblin, C. Northover, S. Pitts, G. D. Poznik, J. Sathirapongsasuti, J. Shelton, S. Shringarpure, C. Tian, J. Tung, V. Vacic, Xin Wang, C. H. Wilson, Tim Anderson, Steven R Bentley, J. Dalrymple-Alford, Javed Fowdar, G. Halliday, A. Henders, I. Hickie, Irfahan Kassam, Martin Kennedy, J. Kwok, S. Lewis, G. Mellick, Grant Montgomery, J. Pearson, T. Pitcher, J. Sidorenko, P. Silburn, C. Vallerga, P. Visscher, L. Wallace, N. Wray, Futao Zhang +236 moresemanticscholar +1 more sourceA subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli +3 morewiley +1 more source
