Results 171 to 180 of about 22,469,227 (260)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Exploring genetic diversity in genome-wide association studies and polygenic risk scores in the admixed Brazilian population. [PDF]

Genet Mol Biol
Molck MC, Santos LHBD, Oliveira TC, Lopes-Cendes I.   +3 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Genetic control of wheat flour end-use quality and rheology by genome-wide association studies. [PDF]

Plant Genome
Menor de Gaspar J, Cuthbert RD, Yuefeng R, Knox R, Fu B, Wang K, Sangah JS, Berraies S, Meyer B, Bokore FE, Isidro Y Sánchez J.   +10 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Disentangling Sex Differences in Sulfonylurea Drug Response With Genome-Wide Association Studies in Individuals With Type 2 Diabetes. [PDF]

Clin Pharmacol Ther
Breeyear JH, House JS, Kvale M, Nam S, Akhtari FS, Shah HS, Hedderson MM, Giacomini KM, Mychaleckyj JC, Doria A, Wagner MJ, Li JH, Yee SW, Buse JB, Woychik RP, Rotroff DM, Motsinger-Reif AA.   +16 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementias. [PDF]

Nat Genet
EADB, EADI, Bonn, ADGC, CHARGE, FinnGen, GERAD, GR@ACE/DEGESCO, PGC-ALZ.   +8 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Genome-wide association studies of infant and toddler temperament in European and multi-ancestry populations. [PDF]

Nat Hum Behav
Hollowell A, Gui A, Wigdor E, Morgan MJ, Hannigan LJ, Corfield EC, Pool R, Bruins S, Ask H, Middeldorp CM, Pourcain BS, Bartels M, Boomsma DI, Hartman CA, Noda A, Takahashi I, Ishikuro M, Obara T, Kuriyama S, Mufford MS, Lake MT, Stein DJ, Zar HJ, Hoffman N, Robinson EB, Børglum AD, Zhang X, Warrier V, Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, Arichi T, Johnson MH, Dudbridge F, Sanders SJ, Havdahl A, Ronald A.   +34 more
europepmc   +1 more source