Results 11 to 20 of about 669,401 (295)
An Analysis Pipeline for Genome-wide Association Studies
Cancer Informatics, 2008 We developed an efficient pipeline to analyze genome-wide association study single nucleotide polymorphism scan results. Perl scripts were used to convert genotypes called using the BRLMM algorithm into a modified PB format.
Stefan Stefanov +2 more
doaj +2 more sources
Performance of epistasis detection methods in semi-simulated GWAS
BMC Bioinformatics, 2018 Background Part of the missing heritability in Genome Wide Association Studies (GWAS) is expected to be explained by interactions between genetic variants, also called epistasis. Various statistical methods have been developed to detect epistasis in case-
Clément Chatelain +3 more
doaj +1 more source
Pathway Analysis of Metabolic Syndrome Using a Genome-Wide Association Study of Korea Associated Resource (KARE) Cohorts [PDF]
Genomics & Informatics, 2014 Metabolic syndrome (MetS) is a complex disorder related to insulin resistance, obesity, and inflammation. Genetic and environmental factors also contribute to the development of MetS, and through genome-wide association studies (GWASs), important ...
Unjin Shim +3 more
doaj +1 more source
Genome-Wide Association Studies of Asthma
Allergology International, 2011 Bronchial asthma is a common inflammatory disease caused by a combination of genetic and environmental factors. To discover the genes and cellular pathways underlying asthma, a large number of genetic studies have been conducted.
Mayumi Tamari +2 more
doaj +1 more source
Optimized homomorphic encryption solution for secure genome-wide association studies
BMC Medical Genomics, 2020 Background Genome-Wide Association Studies (GWAS) refer to observational studies of a genome-wide set of genetic variants across many individuals to see if any genetic variants are associated with a certain trait.
Marcelo Blatt +4 more
doaj +1 more source
Variance component model to account for sample structure in genome-wide association studies
Nature Genetics, 2010 Although genome-wide association studies (GWASs) have identified numerous loci associated with complex traits, imprecise modeling of the genetic relatedness within study samples may cause substantial inflation of test statistics and possibly spurious ...
H. Kang +7 more
semanticscholar +1 more source
Turning genome-wide association study findings into opportunities for drug repositioning
Computational and Structural Biotechnology Journal, 2020 Drug development is a very costly and lengthy process, while repositioned or repurposed drugs could be brought into clinical practice within a shorter time-frame and at a much reduced cost.
Alexandria Lau, Hon-Cheong So
doaj +1 more source
An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank
Nature Neuroscience, 2021 UK Biobank is a major prospective epidemiological study, including multimodal brain imaging, genetics and ongoing health outcomes. Previously, we published genome-wide associations of 3,144 brain imaging-derived phenotypes, with a discovery sample of 8 ...
Stephen M. Smith +6 more
semanticscholar +1 more source
SNP set association analysis for genome-wide association studies. [PDF]
PLoS ONE, 2013 Genome-wide association study (GWAS) is a promising approach for identifying common genetic variants of the diseases on the basis of millions of single nucleotide polymorphisms (SNPs).
Min Cai +9 more
doaj +1 more source
BMC Bioinformatics, 2012 Background Genome-wide association studies (GWAS) with metabolic traits and metabolome-wide association studies (MWAS) with traits of biomedical relevance are powerful tools to identify the contribution of genetic, environmental and lifestyle factors to ...
Petersen Ann-Kristin +6 more
doaj +1 more source