Results 221 to 230 of about 669,401 (295)

Twenty years of genome-wide association studies: Health translation challenges and AI opportunities. [PDF]

Eur J Hum Genet
Huang J, McLean GR, Franke A.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Meta-analyses of clozapine, norclozapine levels and their ratio across three genome wide association studies. [PDF]

Transl Psychiatry
Rask SM, Solismaa A, Ahola-Olli A, Molden E, O'Connell KS, Lyytikäinen LP, Mononen N, Lehtimäki T, Kampman O.   +8 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Genome-Wide Association Studies for Grain Micronutrient Concentration in Spring Wheat (<i>Triticum aestivum</i> L.). [PDF]

Plants (Basel)
Negi C, Kumar K, Dhariwal R, Vyas P, Vasistha NK.   +4 more
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Genome wide association studies in yam reveal the challenge of high heterozygosity. [PDF]

Sci Rep
Agre PA, Darkwa K, Kohtaro I, Matsumoto R, Asfaw A.   +4 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Genetic heterogeneity and homogeneity among orofacial cleft subtypes: genome-wide association studies in the cleft collective. [PDF]

Hum Mol Genet
Dack K, Ludwig KU, Stergiakouli E, Sandy J, Aryee S, Davey Smith G, Davies A, Wren Y, Sharp GC, Humphries K, Mangold E, Goudswaard L, Ho K, Dudding T, Lewis SJ.   +14 more
europepmc   +1 more source

Additional file 6: of Genome-wide association study for salinity tolerance at the flowering stage in a panel of rice accessions from Thailand

, 2019
Chakkree Lekklar, Monnat Pongpanich, Duangjai Suriya-arunroj, Aumnart Chinpongpanich, Helen Tsai, Luca Comai, Supachitra Chadchawan, Teerapong Buaboocha   +7 more
openalex   +1 more source