Results 81 to 90 of about 669,401 (295)

Evaluation of Fusarium Head Blight Resistance Effects by Haplotype-Based Genome-Wide Association Study in Winter Wheat Lines Derived by Marker Backcrossing Approach [PDF]

, 2022
Magdalena Radecka-Janusik, Urszula Piechota, Dominika Piaskowska, Tomasz Góral, Paweł Czembor   +4 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

scoreInvHap: Inversion genotyping for genome-wide association studies.

PLoS Genetics, 2019
Polymorphic inversions contribute to adaptation and phenotypic variation. However, large multi-centric association studies of inversions remain challenging. We present scoreInvHap, a method to genotype inversions from SNP data for genome-wide association
Carlos Ruiz-Arenas, Alejandro Cáceres, Marcos López-Sánchez, Ignacio Tolosana, Luis Pérez-Jurado, Juan R González   +5 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Do we need more genome wide association studies?

Haematologica, 2021
Stephan Menzel
doaj   +1 more source

Genome-wide Association Studies of Retinal Vessel Tortuosity Identify Numerous Novel Loci Revealing Genes and Pathways Associated With Ocular and Cardiometabolic Diseases

, 2023
Mattia Tomasoni, Michael J. Beyeler, Sofía Ortín Vela, Ninon Mounier, Eleonora Porcu, Tanguy Corre, Daniel Krefl, Alexander L. Button, Hana Abouzeid, Lazaros Konstantinidis, Murielle Bochud, Reinier O. Schlingemann, Ciara Bergin, Sven Bergmann   +13 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Interpreting meta-analyses of genome-wide association studies.

PLoS Genetics, 2012
Meta-analysis is an increasingly popular tool for combining multiple genome-wide association studies in a single analysis to identify associations with small effect sizes.
Buhm Han, Eleazar Eskin
doaj   +1 more source

Genetic Analyses and Genome-Wide Association Studies on Pathogen Resistance of Bos taurus and Bos indicus Cattle Breeds in Cameroon [PDF]

, 2021
Babette Abanda, M Schmid, Archile Paguem, Hanna Iffland, Siegfried Preuß, Alfons Renz, Albert Eisenbarth   +6 more
openalex   +1 more source

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Nature Communications, 2019
The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association ...
C. Nievergelt, A. Maihofer, T. Klengel, Elizabeth G. Atkinson, Chia-Yen Chen, Karmel W. Choi, J. Coleman, S. Dalvie, L. Duncan, J. Gelernter, D. Levey, M. Logue, R. Polimanti, Allison Provost, A. Ratanatharathorn, M. Stein, Katy Torres, A. Aiello, L. Almli, A. Amstadter, S. Andersen, O. Andreassen, P. Arbisi, A. Ashley-Koch, S. Austin, E. Avdibegović, D. Babic, Marie Bækvad-Hansen, D. Baker, J. Beckham, L. Bierut, J. Bisson, M. Boks, Elizabeth A. Bolger, A. Børglum, B. Bradley, M. Brashear, G. Breen, R. Bryant, A. Bustamante, J. Bybjerg-Grauholm, J. Calabrese, J. Caldas-de-Almeida, A. Dale, M. Daly, N. Daskalakis, J. Deckert, D. Delahanty, Michelle F. Dennis, S. Disner, K. Domschke, A. Dzubur-Kulenovic, Christopher R. Erbes, Alexandra Evans, L. Farrer, N. Feeny, J. Flory, D. Forbes, C. Franz, S. Galea, M. Garrett, B. Gelaye, E. Geuze, Charles F. Gillespie, A. Uka, S. Gordon, G. Guffanti, R. Hammamieh, Supriya Harnal, M. Hauser, A. Heath, S. Hemmings, D. Hougaard, M. Jakovljevič, M. Jett, Eric O. Johnson, I. Jones, T. Jovanović, X. Qin, A. Junglen, Karen-Inge Karstoft, M. Kaufman, R. Kessler, Alaptagin Khan, N. Kimbrel, A. King, N. Koen, H. Kranzler, W. Kremen, B. Lawford, L. Lebois, Catrin E Lewis, S. Linnstaedt, A. Lori, B. Lugonja, J. Luykx, M. Lyons, J. Maples-Keller, C. Marmar, Alicia R. Martin, N. Martin, D. Maurer, M. Mavissakalian, A. McFarlane, R. McGlinchey, K. McLaughlin, S. Mclean, S. Mcleay, D. Mehta, W. Milberg, Mark W. Miller, R. Morey, C. P. Morris, O. Mors, P. Mortensen, B. Neale, E. Nelson, M. Nordentoft, S. Norman, M. O'Donnell, H. Orcutt, M. Panizzon, E. Peters, A. Peterson, Matthew Peverill, R. Pietrzak, Melissa A. Polusny, J. Rice, S. Ripke, V. Risbrough, A. Roberts, Alex O. Rothbaum, B. Rothbaum, P. Roy-Byrne, K. Ruggiero, A. Rung, B. Rutten, N. Saccone, S. Sanchez, D. Schijven, S. Seedat, Antonia V. Seligowski, J. Seng, Christina M. Sheerin, D. Silove, Alicia K. Smith, J. Smoller, S. Sponheim, Dan J Stein, Jennifer S Stevens, J. Sumner, Martin H. Teicher, W. Thompson, E. Trapido, M. Uddin, R. Ursano, L. L. van den Heuvel, M. V. van Hooff, E. Vermetten, C. Vinkers, J. Voisey, Yunpeng Wang, Zhewu Wang, T. Werge, Michelle A Williams, D. Williamson, S. Winternitz, C. Wolf, E. Wolf, J. Wolff, R. Yehuda, R. Young, K. Young, Hongyu Zhao, L. Zoellner, I. Liberzon, K. Ressler, M. Haas, K. Koenen   +178 more
semanticscholar   +1 more source