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Genome-Wide Association Studies of Asthma
Allergology International, 2011 Bronchial asthma is a common inflammatory disease caused by a combination of genetic and environmental factors. To discover the genes and cellular pathways underlying asthma, a large number of genetic studies have been conducted.
Mayumi Tamari +2 more
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Genome-wide association studies [PDF]
Nature Reviews Methods Primers, 2021 Genome- wide association studies (GWAS) test hundreds of thousands of genetic variants across many genomes to find those statistically associated with a specific trait or disease. This methodology has generated a myriad of robust associations for a range of traits and diseases, and the number of associated variants is expected to grow steadily as GWAS ...
Emil Uffelmann +8 more
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Cells, 2022 Several genes associated with periodontitis have been identified through genome-wide association studies (GWAS); however, known genes only explain a minority of the estimated heritability.
Guirong Zhu +4 more
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Identification of Druggable Genes for Asthma by Integrated Genomic Network Analysis
Biomedicines, 2022 Asthma is a common and heterogeneous disease characterized by chronic airway inflammation. Currently, the two main types of asthma medicines are inhaled corticosteroids and long-acting β2-adrenoceptor agonists (LABAs).
Wirawan Adikusuma +7 more
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The genetics of obesity: A narrative review [PDF]
Precision and Future Medicine, 2022 Monogenic obesity is a rare, early-onset, and severe form of obesity that has a Mendelian inheritance pattern, high penetrance, and large genetic effect. In contrast, common polygenic obesity is more prevalent and has pattern of heritability derived from
Young Bae Sohn
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Replication of the Association of the 6q22.31c Locus near with Pulse Rate in the Korean Population [PDF]
Genomics & Informatics, 2012 Pulse rate is known to be related to diverse phenotypes, such as cardiovascular diseases, lifespan, arrhythmia, hypertension, lipids, diabetes, and menopause. We have reported two genomewide significant genetic loci responsible for the variation in pulse
Nam Hee Kim +3 more
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Genome-Wide Association Studies in Atherosclerosis [PDF]
Current Atherosclerosis Reports, 2011 Cardiovascular disease remains the major cause of worldwide morbidity and mortality. Its pathophysiology is complex and multifactorial. Because the phenotype of cardiovascular disease often shows a marked heritable pattern, it is likely that genetic factors play an important role.
Sivapalaratnam, S. +7 more
openaire +4 more sources
How data science and AI-based technologies impact genomics
Singapore Medical Journal, 2023 Advancements in high-throughput sequencing have yielded vast amounts of genomic data, which are studied using genome-wide association study (GWAS)/phenome-wide association study (PheWAS) methods to identify associations between the genotype and phenotype.
Jing Lin, Kee Yuan Ngiam
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Genome-Wide Association Study on Longitudinal Change in Fasting Plasma Glucose in Korean Population [PDF]
Diabetes & Metabolism Journal, 2023 Background Genome-wide association studies (GWAS) on type 2 diabetes mellitus (T2DM) have identified more than 400 distinct genetic loci associated with diabetes and nearly 120 loci for fasting plasma glucose (FPG) and fasting insulin level to date ...
Heejin Jin +6 more
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Dissecting the genetic heterogeneity of gastric cancerResearch in context
EBioMedicine, 2023 Summary: Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes.
Timo Hess +133 more
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