Results 91 to 100 of about 674,070 (352)

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

A Genome-Wide Association Study for Calving Interval in Holstein Dairy Cows Using Weighted Single-Step Genomic BLUP Approach

Animals, 2020
The aim of the present study was to identify genomic region(s) associated with the length of the calving interval in primiparous (n = 6866) and multiparous (n = 5071) Holstein cows.
Hadi Atashi, Mazdak Salavati, Jenne De Koster, Mark A. Crowe, Geert Opsomer, Miel Hostens, The GplusE Consortium   +6 more
doaj   +1 more source

Large-scale meta–genome-wide association study reveals common genetic factors linked to radiation-induced acute toxicities across cancer types [PDF]

, 2023
Elnaz Naderi, Miguel E. Aguado‐Barrera, L.M.H. Schack, Leila Dorling, Tim Rattay, Laura Fachal, Holly Summersgill, Laura Martínez-Calvo, Ceilidh Welsh, Tom Dudding, Yasmin Odding, Ana Varela-Pazos, R. Jena, David Thomson, R.J.H.M. Steenbakkers, Joe Dennis, Ramón Lobato-Busto, Jan Alsner, Andy Ness, Chris Nutting, Antonio Gómez‐Caamaño, Jesper Grau Eriksen, Steve Thomas, Amy Bates, Adam Webb, Ananya Choudhury, Barry S. Rosenstein, Begoña Taboada‐Valladares, Carsten Herskind, D. Azria, David P. Dearnaley, Dirk De Ruysscher, Elena Sperk, Emma Hall, Hilary Stobart, Jenny Chang‐Claude, Kim De Ruyck, Liv Veldeman, Manuel Altabas, Maria Carmen De Santis, Marie‐Pierre Farcy‐Jacquet, Marlon R. Veldwijk, Matthew R. Sydes, Matthew Parliament, Nawaid Usmani, N.G. Burnet, Petra Seibold, R.P. Symonds, Rebecca Elliott, Renée Bultijnck, Sara Gutiérrez‐Enríquez, Meritxell Mollà, S. Gulliford, Sheryl Green, T. Rancati, Victoria Reyes, Ana M. Carballo, Paula Peleteiro, Paloma Sosa‐Fajardo, Chris Parker, Valérie Fonteyne, Kerstie Johnson, Maarten Lambrecht, Ben Vanneste, Riccardo Valdagni, Alexandra Giraldo, Mónica Ramos, Brenda Diergaarde, Geoffrey Liu, Suzanne M. Leal, Melvin L.K. Chua, Miranda Pring, Jens Overgaard, Luis M Cascallar-Caneda, Fréderic Duprez, Chris J. Talbot, Gillian C. Barnett, Alison M. Dunning, Ana Vega, Christian Nicolaj Andreassen, Johannes A. Langendijk, Catharine West, Behrooz Z. Alizadeh, Sarah L. Kerns, Elnaz Naderi, Miguel E. Aguado‐Barrera, L.M.H. Schack, Leila Dorling, Tim Rattay, Laura Fachal, Holly Summersgill, Laura Martínez-Calvo, Ceilidh Welsh, Tom Dudding, Yasmin Odding, Ana Varela-Pazos, R. Jena, David Thomson, R.J.H.M. Steenbakkers, Joe Dennis   +99 more
openalex   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Enhancer RNA Transcriptome‐Wide Association Study Reveals a Distinctive Class of Pan‐Cancer Susceptibility eRNAs

Advanced Science
Many cancer risk variants are located within enhancer regions and lack sufficient molecular interpretation. Here, we constructed the first comprehensive atlas of enhancer RNA (eRNA)‐mediated genetic effects from 28 033 RNA sequencing samples across 11 ...
Wenyan Chen, Zeyang Wang, Yinuo Wang, Jianxiang Lin, Shuxin Chen, Hui Chen, Xuelian Ma, Xudong Zou, Xing Li, Yangmei Qin, Kewei Xiong, Xixian Ma, Qi Liao, Yunbo Qiao, Lei Li   +14 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Peer Review #1 of "Genome-wide association study of yield components in spring wheat collection harvested under two water regimes in Northern Kazakhstan (v0.1)"

, 2021
MAR Rashid
openalex   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Additional file 5 of Identification of sex determination locus in sea cucumber Apostichopus japonicus using genome-wide association study

, 2022
Yixin Wang, Yujia Yang, Yulong Li, Muyan Chen   +3 more
openalex   +1 more source

Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

bioRxiv, 2019
Rationale Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterised by scarring of the lung that is believed to result from an atypical response to injury of the epithelium.
R. Allen, B. Guillen-Guio, J. Oldham, Shwu-Fan Ma, A. Dressen, Megan L. Paynton, L. M. Kraven, M. Obeidat, Xuan Li, M. Ng, R. Braybrooke, M. Molina-Molina, B. Hobbs, R. Putman, P. Sakornsakolpat, H. Booth, W. Fahy, S. Hart, M. Hill, N. Hirani, R. Hubbard, R. McAnulty, A. Millar, V. Navaratnam, E. Oballa, H. Parfrey, G. Saini, M. Whyte, Yingze Zhang, N. Kaminski, A. Adegunsoye, M. Strek, M. Neighbors, X. R. Sheng, G. Gudmundsson, V. Gudnason, H. Hatabu, D. Lederer, A. Manichaikul, J. Newell, G. O'Connor, V. Ortega, Hanfei Xu, T. Fingerlin, Y. Bossé, K. Hao, P. Joubert, D. Nickle, D. Sin, W. Timens, D. Furniss, A. Morris, K. Zondervan, I. Hall, I. Sayers, M. Tobin, T. Maher, M. Cho, G. Hunninghake, D. Schwartz, B. Yaspan, P. Molyneaux, C. Flores, I. Noth, R. Jenkins, L. Wain   +65 more
semanticscholar   +1 more source