Results 91 to 100 of about 1,111,517 (383)

Genome-Wide Association Studies in Glioma [PDF]

Cancer Epidemiology, Biomarkers & Prevention, 2018
Abstract Since the first reports in 2009, genome-wide association studies (GWAS) have been successful in identifying germline variants associated with glioma susceptibility. In this review, we describe a chronological history of glioma GWAS, culminating in the most recent study comprising 12,496 cases and 18,190 controls. We additionally
Kinnersley, B, Houlston, RS, Bondy, ML
openaire   +3 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Evaluation of Fusarium Head Blight Resistance Effects by Haplotype-Based Genome-Wide Association Study in Winter Wheat Lines Derived by Marker Backcrossing Approach [PDF]

, 2022
Magdalena Radecka-Janusik, Urszula Piechota, Dominika Piaskowska, Tomasz Góral, Paweł Czembor   +4 more
openalex   +1 more source

Rheumatoid Arthritis Naive T Cells Share Hypermethylation Sites With Synoviocytes. [PDF]

, 2017
ObjectiveTo determine whether differentially methylated CpGs in synovium-derived fibroblast-like synoviocytes (FLS) of patients with rheumatoid arthritis (RA) were also differentially methylated in RA peripheral blood (PB) samples.MethodsFor this study ...
Barcellos, Lisa F, Cole, Michael, Criswell, Lindsey A, Firestein, Gary S, Graf, John, Halperin, Eran, Harrison, Ruby, Holingue, Calliope, Link, Thomas, Quach, Diana, Quach, Hong L, Rahmani, Elior, Rhead, Brooke, Shah, Khooshbu, Shao, Xiaorong, Sinclair, Elizabeth, Wang, Wei   +16 more
core   +1 more source

Association of OPRM1 Functional Coding Variant With Opioid Use Disorder: A Genome-Wide Association Study.

JAMA psychiatry, 2020
Importance With the current opioid crisis, it is important to improve understanding of the biological mechanisms of opioid use disorder (OUD). Objectives To detect genetic risk variants for OUD and determine genetic correlations and causal association ...
Hang Zhou, C. Rentsch, Zhongshan Cheng, R. Kember, Y. Nuñez, Richard Sherva, J. Tate, Cecilia Dao, Ke Xu, R. Polimanti, L. Farrer, A. Justice, H. Kranzler, J. Gelernter   +13 more
semanticscholar   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci. [PDF]

, 2013
Genetic and environmental components as well as their interaction contribute to the risk of schizophrenia, making it highly relevant to include environmental factors in genetic studies of schizophrenia.
A D Børglum, A Hedemand, A Ludwig, A Miyashita, A Terracciano, A Uitterlinden, AC Need, AC Ravanpay, AD Skol, AG Cardno, AR Fisher, AR Morgan, AS Brown, AS Brown, AS Yap, B Janssens, B Nørgaard-Pedersen, B Xu, BH Shirts, BJ Fredette, BM Gumbiner, BM Neale, BM Neale, C B Pedersen, C Ciatto, C Wiuf, CB Pedersen, CE Murcray, CM Nievergelt, D Demontis, D Demontis, D M Hougaard, D Moreno-De-Luca, DB Boivin, GR Abecasis, H Le-Niculescu, H Stefansson, H Stefansson, HA Mansour, HA Mansour, HC So, I Sousa, J Grove, J Lasky-Su, J Majercak, J Novembre, J Pallesen, J Shi, J van Os, J Yang, JA Embil, JE Buizer-Voskamp, JJ Kim, K Wang, K Wulff, K Zhou, KH Baratz, KP Lesch, L Athanasiu, LN Moens, M Didriksen, M M Nöthen, M Mattheisen, M Nordentoft, M Nyegaard, M Nyegaard, M Rietschel, M Rietschel, M Scholz, M Takeichi, M Takeichi, M V Hollegaard, ML Rao, MS Keshavan, MV Hollegaard, N Cermakian, N Patterson, O Mors, O Mors, P B Mortensen, PA Holmans, PB Mortensen, PF Sullivan, R A Ophoff, R H Yolken, R Steinberg, RL Schelonka, S Cichon, S Purcell, S Ripke, S Steinberg, SA Riazuddin, SA Staras, SH Lee, SJ Sanders, SL Buka, SL Buka, SM Purcell, T Miyoshi, T Takeuchi, T Ørntoft, TJ Crow, TL Edwards, V Busby, V Soria, VR Sobrado, X Liang, Y Adachi, Y Li   +108 more
core   +4 more sources

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration

bioRxiv, 2019
Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we identify 143 independent loci in 112 1-Mb regions, providing ...
J. Revez, Tian Lin, Zhen Qiao, Angli Xue, Y. Holtz, Zhihong Zhu, Jian Zeng, Huanwei Wang, J. Sidorenko, K. Kemper, A. Vinkhuyzen, J. Frater, D. Eyles, T. Burne, B. Mitchell, N. Martin, G. Zhu, P. Visscher, Jian Yang, N. Wray, J. Mcgrath   +20 more
semanticscholar   +1 more source

Multi-trait analysis for genome-wide association study of five psychiatric disorders

Translational Psychiatry, 2020
We conducted a cross-trait meta-analysis of genome-wide association study on schizophrenia (SCZ) ( n  = 65,967), bipolar disorder (BD) ( n  = 41,653), autism spectrum disorder (ASD) ( n  = 46,350), attention deficit hyperactivity disorder (ADHD) ( n ...
Yulu Wu, Hongbao Cao, A. Baranova, Hailiang Huang, Sheng Li, Lei Cai, Shuquan Rao, M. Dai, M. Xie, Yikai Dou, Qinjian Hao, Ling Zhu, Xiangrong Zhang, Yin Yao, Fuquan Zhang, Mingqing Xu, Qiang Wang   +16 more
semanticscholar   +1 more source

Voxelwise genome-wide association study (vGWAS) [PDF]

NeuroImage, 2010
The structure of the human brain is highly heritable, and is thought to be influenced by many common genetic variants, many of which are currently unknown. Recent advances in neuroimaging and genetics have allowed collection of both highly detailed structural brain scans and genome-wide genotype information.
Jason L, Stein, Xue, Hua, Suh, Lee, April J, Ho, Alex D, Leow, Arthur W, Toga, Andrew J, Saykin, Li, Shen, Tatiana, Foroud, Nathan, Pankratz, Matthew J, Huentelman, David W, Craig, Jill D, Gerber, April N, Allen, Jason J, Corneveaux, Bryan M, Dechairo, Steven G, Potkin, Michael W, Weiner, Paul, Thompson   +18 more
openaire   +2 more sources