Results 101 to 110 of about 1,051,148 (367)
Genome-Wide Association Study of Vascular Dementia [PDF]
Stroke, 2012 Background and Purpose— Most studies investigating the genetics of dementia have focused on Alzheimer disease, but little is known about the genetics of vascular dementia. The aim of our study was to identify new loci associated with vascular dementia. Methods— We performed a genome-Schrijvers, Elisabeth M.C., Schürmann, Britta, Koudstaal, Peter J., Van Den Bussche, Hendrik, Van Duijn, Cornelia M., Hentschel, Frank, Heun, Reinhard, Hofman, Albert, Jessen, Frank, Kölsch, Heike, Kornhuber, Johannes, Peters, Oliver, Rivadeneira, Fernando, Rüther, Eckart, Uitterlinden, André G., Riedel-Heller, Steffi, Dichgans, Martin, Wiltfang, Jens, Maier, Wolfgang, Breteler, Monique M.B., Ikram, M. Arfan +20 moreopenaire +5 more sourcesMulticentric Genome-Wide Association Study for Primary Spontaneous Pneumothorax [PDF]
, 2016 Despite elevated incidence and recurrence rates for Primary Spontaneous Pneumothorax (PSP), little is known about its etiology, and the genetics of idiopathic PSP remains unexplored.Abrantes, P, Feijó, S, Fradinho, M, Francisco, V, Malheiro, F, Monteiro, M, Moura E Sá, J, Negrão, L, Neves, J, Norte, A, Oliveira, M, Oliveira, SA, Reis, E, Robalo-Cordeiro, C, Santos, P, Sousa, I, Sousa, S, Teixeira, G +17 morecore +2 more sourcesAssociation between human blood metabolome and the risk of delirium: a Mendelian Randomization study
Frontiers in EndocrinologyBackgroundDelirium significantly contributes to both mortality and morbidity among hospitalized older adults. Furthermore, delirium leads to escalated healthcare expenditures, extended hospital stays, and enduring cognitive deterioration, all of which ...Chubing Long, Chubing Long, Dong Lin, Dong Lin, Lieliang Zhang, Lieliang Zhang, Yue Lin, Yue Lin, Qing Yao, Qing Yao, Guangyong Zhang, Guangyong Zhang, Longshan Li, Longshan Li, Hailin Liu, Hailin Liu, Jun Ying, Jun Ying, Xifeng Wang, Xifeng Wang, Fuzhou Hua, Fuzhou Hua +21 moredoaj +1 more sourceGenome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates
Nature Communications, 2019 Sleep is an essential state of decreased activity and alertness but molecular factors regulating sleep duration remain unknown. Through genome-wide association analysis in 446,118 adults of European ancestry from the UK Biobank, we identify 78 loci for ...H. Dashti, Samuel E Jones, Andrew R Wood, J. Lane, V. V. van Hees, Heming Wang, Jessica A Rhodes, Yanwei Song, K. Patel, Simon G Anderson, R. Beaumont, D. Bechtold, Jack Bowden, B. Cade, Marta Garaulet, S. Kyle, Max A Little, A. Loudon, A. Luik, F. Scheer, K. Spiegelhalder, J. Tyrrell, D. J. Gottlieb, Henning Tiemeier, David W. Ray, Shaun M. Purcell, T. Frayling, S. Redline, D. A. Lawlor, Martin K Rutter, M. Weedon, Richa Saxena +31 moresemanticscholar +1 more sourceCell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens +17 morewiley +1 more sourceA Genome-Wide Association Study of Myasthenia Gravis [PDF]
JAMA Neurology, 2015 Myasthenia gravis is a chronic, autoimmune, neuromuscular disease characterized by fluctuating weakness of voluntary muscle groups. Although genetic factors are known to play a role in this neuroimmunological condition, the genetic etiology underlying myasthenia gravis is not well understood.To identify genetic variants that alter susceptibility to ...Renton, Ae, Pliner, Ha, Provenzano, Carlo, Evoli, Amelia, Ricciardi, R, Nalls, Ma, Marangi, Giuseppe, Abramzon, Y, Arepalli, S, Chong, S, Hernandez, Dg, Johnson, Jo, Bartoccioni, Emanuela, Scuderi, Flavia, Maestri, M, Gibbs, Jr, Errichiello, E, Chiò, A, Restagno, G, Sabatelli, Mario, Macek, M, Scholz, Sw, Corse, A, Chaudhry, V, Benatar, M, Barohn, Rj, Mcvey, A, Pasnoor, M, Dimachkie, Mm, Rowin, J, Kissel, J, Freimer, M, Kaminski, Hj, Sanders, Db, Lipscomb, B, Massey, Jm, Chopra, M, Howard, Jf, Koopman, Wj, Nicolle, Mw, Pascuzzi, Rm, Pestronk, A, Wulf, C, Florence, J, Blackmore, D, Soloway, A, Siddiqi, Z, Muppidi, S, Wolfe, G, Richman, D, Mezei, Mm, Jiwa, T, Oger, J, Drachman, Db, Traynor, Bj +54 moreopenaire +5 more sourcesGenome-wide association study of endometrial cancer in E2C2 [PDF]
, 2013 Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is the most common gynecological malignancy in developed countries and the fourth most common cancer among US women.Alison M. Dunning, Amanda B. Spurdle, Amanda Black, Anthony M. Magliocco, Brian E. Henderson, Carlotta Sacerdote, Christine M. Friedenreich, Christopher Haiman, Chu Chen, Constance Chen, David J. Hunter, David VanDen Berg, Deborah Thompson, Douglas F. Easton, Elizabeth Holliday, Fredrick Schumacher, Hannah P. Yang, Harvey Risch, Herbert Yu, Immaculata De Vivo, Irene Orlow, Jennifer Doherty, Jennifer Prescott, Jirong Long, Jodie N. Painter, John Attia, Jolanta Lissowska, Linda S. Cook, Lingeng Lu, Loic Le Marchand, Loreall Pooler, Louise Brinton, Lucy Xia, Mark McEvoy, Marta Crous-Bou, Mia M. Gaudet, Montserrat Garcia-Closas, Nicolas Wentzensen, Noel S. Weiss, null null, Pamela L. Horn-Ross, Patricia Hartge, Peter Kraft, Radhai Rastogi, Rodney J. Scott, Sara H. Olson, Stephen Chanock, Susan E. Hankinson, Timothy R. Rebbeck, Tracy A. O’Mara, Veronica Wendy Setiawan, Wei Zheng, Xiao-ou Shu, Xiaolin Liang, Xin Sheng, Yong-Bing Xiang +55 morecore +1 more sourceGenome-Wide Association Study Reveals Candidate Genes for Litter Size Traits in Pelibuey Sheep
Animals, 2020 The Pelibuey sheep has adaptability to climatic variations, resistance to parasites, and good maternal ability, whereas some ewes present multiple births, which increases the litter size in farm sheep.Wilber Hernández-Montiel, Mario Alberto Martínez-Núñez, Julio Porfirio Ramón-Ugalde, Sergio Iván Román-Ponce, Rene Calderón-Chagoya, Roberto Zamora-Bustillos +5 moredoaj +1 more sourceMET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne +14 morewiley +1 more sourceResponse to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes
Molecular Oncology, EarlyView.Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux +16 morewiley +1 more source
