Results 101 to 110 of about 1,111,517 (383)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Genetic Association Study Revealed Three Loci Were Associated Risk of Myopia Among Minors

Pharmacogenomics and Personalized Medicine, 2021
Zixiu Zhou, Sizhen Li, Qingsong Yang, Xiaodong Yang, Kuanxiao Hao, Yating Liu, Shanshan Xu Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, 211102, People’s Republic of ChinaCorrespondence: Sizhen LiNanjing Tongren ...
Zhou Z, Li S, Yang Q, Yang X, Hao K, Liu Y, Xu S   +6 more
doaj  

Genome-Wide Association Study Identifies Candidate Loci Associated with Platelet Count in Koreans [PDF]

Genomics & Informatics, 2014
Platelets are derived from the fragments that are formed from the cytoplasm of bone marrow megakaryocytes-small irregularly shaped anuclear cells. Platelets respond to vascular damage, contracts blood vessels, and attaches to the damaged region, thereby ...
Ji Hee Oh, Yun Kyoung Kim, Sanghoon Moon, Young Jin Kim, Bong-Jo Kim   +4 more
doaj   +1 more source

A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis. [PDF]

, 2011
BackgroundRheumatoid arthritis (RA) can be divided into two major subsets based on the presence or absence of antibodies to citrullinated peptide antigens (ACPA).
Alfredsson, Lars, Ding, Bo, Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study group, Klareskog, Lars, Ong, Rick TH, Padyukov, Leonid, Rönnelid, Johan, Seddighzadeh, Maria, Seielstad, Mark   +8 more
core  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

A genome-wide association study suggests an association of Chr8p21.3 (GFRA2) with diabetic neuropathic pain [PDF]

, 2014
BACKGROUND: Neuropathic pain, caused by a lesion or a disease affecting the somatosensory system, is one of the most common complications in diabetic patients.
, , Colhoun, H. M., Deshmukh, H. A., Donnelly, L. A., Liu, Y., Meng, W., Morris, A. D., Palmer, C. N. A., Smith, B. H., van Zuydam, N. R., Zhou, K.   +11 more
core   +4 more sources

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations

Nature Communications, 2019
Alcohol consumption level and alcohol use disorder (AUD) diagnosis are moderately heritable traits. We conduct genome-wide association studies of these traits using longitudinal Alcohol Use Disorder Identification Test-Consumption (AUDIT-C) scores and ...
H. Kranzler, Hang Zhou, R. Kember, Rachel Vickers Smith, A. Justice, S. Damrauer, P. Tsao, D. Klarin, A. Baras, Jeffrey Reid, J. Overton, D. Rader, Zhongshan Cheng, J. Tate, W. Becker, J. Concato, Ke Xu, R. Polimanti, Hongyu Zhao, J. Gelernter   +19 more
semanticscholar   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Common variation near ROBO2 is associated with expressive vocabulary in infancy [PDF]

, 2014
Twin studies suggest that expressive vocabulary at ~24 months is modestly heritable. However, the genes influencing this early linguistic phenotype are unknown. Here we conduct a genome-wide screen and follow-up study of expressive vocabulary in toddlers
Ang, Qi W., Cents, Rolieke A. M., Dale, Philip S., Davis, Oliver S. P., Evans, David M., Golding, Jean, Haworth, Claire M. A., Hofman, A., Jaddoe, Vincent Wilfred Vishal-Kapoor, Jarvelin, Marjo-Riitta, Kemp, John P., Meaburn, Emma L., Miller, Laura, O’Reilly, Paul F., Pennell, Craig E., Pillas, Demetris, Plomin, Robert, Price, Tom S., Ring, Susan M., Rivadeneira, Fernando, Rodriguez, Alina, Roulstone, Susan, Smith, George Davey, St Pourcain, Beate, Tiemeier, Henning, Timpson, Nicholas J., Velders, F. P., Verhulst, F. C., Warrington, Nicole M., Whitehouse, Andrew J. O., Wren, Yvonne, Yliherva, Anneli   +31 more
core   +9 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source