Results 111 to 120 of about 1,051,148 (367)

Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS. [PDF]

, 2015
Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by intrusive thoughts and urges and repetitive, intentional behaviors that cause significant distress and impair functioning.
Askland, KD, Bienvenu, OJ, Cullen, BA, Fyer, AJ, Geller, DA, Goes, FS, Grados, MA, Greenberg, BD, Knowles, JA, Lange, C, Liang, K-Y, Maher, B, Mattheisen, M, McCracken, JT, McLaughlin, NC, Murphy, DL, Nestadt, G, Nurmi, EL, Pauls, DL, Piacentini, J, Pulver, AE, Qin, H-D, Rasmussen, SA, Riddle, MA, Samuels, JF, Shugart, YY, Stewart, SE, Valle, D, Wang, Y   +28 more
core  

A genome-wide association study of self-rated health [PDF]

, 2010
Self-rated health questions have been proven to be a highly reliable and valid measure of overall health as measured by other indicators in many population groups.
Gordon, Scott D, Heath, Andrew C, Madden, Pamela A, Martin, Nicholas G, Medland, Sarah E, Montgomery, Grant W, Mosing, Miriam A, Painter, Jodie, Verweij, Karin J.H.   +8 more
core   +2 more sources

Advances in the genetics of myasthenia gravis: insights from cutting-edge neuroscience research

Frontiers in Medicine
Myasthenia gravis (MG) is an autoimmune disorder involving complex interactions between genetic and environmental factors. Genome-wide association studies (GWAS), transcriptome-wide association studies (TWAS), and other methods have identified multiple ...
Zheng Yixian, Wang Hai, Liu Xiuying, Yan Jichun   +3 more
doaj   +1 more source

Genetic Association Study Revealed Three Loci Were Associated Risk of Myopia Among Minors

Pharmacogenomics and Personalized Medicine, 2021
Zixiu Zhou, Sizhen Li, Qingsong Yang, Xiaodong Yang, Kuanxiao Hao, Yating Liu, Shanshan Xu Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, 211102, People’s Republic of ChinaCorrespondence: Sizhen LiNanjing Tongren ...
Zhou Z, Li S, Yang Q, Yang X, Hao K, Liu Y, Xu S   +6 more
doaj  

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations

Nature Communications, 2019
Alcohol consumption level and alcohol use disorder (AUD) diagnosis are moderately heritable traits. We conduct genome-wide association studies of these traits using longitudinal Alcohol Use Disorder Identification Test-Consumption (AUDIT-C) scores and ...
H. Kranzler, Hang Zhou, R. Kember, Rachel Vickers Smith, A. Justice, S. Damrauer, P. Tsao, D. Klarin, A. Baras, Jeffrey Reid, J. Overton, D. Rader, Zhongshan Cheng, J. Tate, W. Becker, J. Concato, Ke Xu, R. Polimanti, Hongyu Zhao, J. Gelernter   +19 more
semanticscholar   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Genome-Wide Association Study Identifies Loci for Liver Enzyme Concentrations in Mexican Americans: The GUARDIAN Consortium. [PDF]

, 2019
ObjectivePopulations of Mexican American ancestry are at an increased risk for nonalcoholic fatty liver disease. The objective of this study was to determine whether loci in known and novel genes were associated with variation in aspartate ...
Chen, Yii-Der I, Fingerlin, Tasha E, Goodarzi, Mark O, Guo, Xiuqing, Langefeld, Carl D, Norris, Jill M, Palmer, Nicholette D, Raffel, Leslie J, Rotter, Jerome I, Taylor, Kent D, Wagenknecht, Lynne E, Wang, Nan, Watanabe, Richard M, Williams, Adrienne H, Xiang, Anny H, Young, Kendra A   +15 more
core   +2 more sources

Whole-genome association and genome partitioning revealed variants and explained heritability for total number of teats in a Yorkshire pig population [PDF]

Asian-Australasian Journal of Animal Sciences, 2018
Objective The study was designed to perform a genome-wide association (GWA) and partitioning of genome using Illumina’s PorcineSNP60 Beadchip in order to identify variants and determine the explained heritability for the total number of teats in ...
Md. Rasel Uzzaman, Jong-Eun Park, Kyung-Tai Lee, Eun-Seok Cho, Bong-Hwan Choi, Tae-Hun Kim   +5 more
doaj   +1 more source

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Diabetes, 2017
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using ...
R. Scott, L. Scott, R. Mägi, L. Marullo, K. Gaulton, M. Kaakinen, N. Pervjakova, T. Pers, Andrew D. Johnson, J. Eicher, A. Jackson, T. Ferreira, Yeji Lee, Clement Ma, V. Steinthorsdottir, G. Thorleifsson, L. Qi, Natalie R. van Zuydam, A. Mahajan, Han Chen, P. Almgren, B. Voight, H. Grallert, M. Müller-Nurasyid, J. Ried, N. W. Rayner, N. Robertson, L. Karssen, E. V. van Leeuwen, Sara M. Willems, C. Fuchsberger, P. Kwan, Tanya M. Teslovich, Pritam Chanda, Man Li, Yingchang Lu, C. Dina, Dorothée Thuillier, L. Yengo, Longda Jiang, T. Sparsø, H. Kestler, H. Chheda, L. Eisele, S. Gustafsson, Mattias Frånberg, R. Strawbridge, R. Benediktsson, Á. Hreidarsson, A. Kong, G. Sigurðsson, N. Kerrison, J. Luan, L. Liang, T. Meitinger, M. Roden, B. Thorand, T. Esko, E. Mihailov, C. Fox, Ching‐Ti Liu, Denis Rybin, B. Isomaa, V. Lyssenko, T. Tuomi, D. Couper, J. Pankow, N. Grarup, C. Have, M. Jørgensen, T. Jørgensen, A. Linneberg, M. Cornelis, R. V. van Dam, D. Hunter, P. Kraft, Qi Sun, S. Edkins, K. Owen, J. Perry, A. Wood, E. Zeggini, Juan Tajes-Fernandes, G. Abecasis, L. Bonnycastle, P. Chines, H. Stringham, H. Koistinen, L. Kinnunen, B. Sennblad, Thomas W. Mühleisen, M. Nöthen, S. Pechlivanis, D. Baldassarre, K. Gertow, S. Humphries, E. Tremoli, N. Klopp, Julia Meyer, G. Steinbach, R. Wennauer, J. Eriksson, S. Mӓnnistö, L. Peltonen, E. Tikkanen, G. Charpentier, Elodie Eury, S. Lobbens, B. Gigante, K. Leander, O. Mcleod, E. Bottinger, O. Gottesman, D. Ruderfer, M. Blüher, P. Kovacs, Anke Tonjes, N. Maruthur, C. Scapoli, R. Erbel, K. Jöckel, S. Moebus, U. de Faire, A. Hamsten, M. Stumvoll, P. Deloukas, P. Donnelly, T. Frayling, A. Hattersley, S. Ripatti, V. Salomaa, N. Pedersen, B. Boehm, R. Bergman, F. Collins, K. Mohlke, J. Tuomilehto, T. Hansen, O. Pedersen, I. Barroso, L. Lannfelt, E. Ingelsson, L. Lind, C. Lindgren, S. Cauchi, P. Froguel, R. Loos, B. Balkau, H. Boeing, P. Franks, A. Barricarte Gurrea, D. Palli, Y. T. van der Schouw, D. Altshuler, L. Groop, C. Langenberg, N. Wareham, E. Sijbrands, C. V. van Duijn, J. Florez, J. Meigs, E. Boerwinkle, C. Gieger, K. Strauch, A. Metspalu, A. Morris, C. Palmer, F. Hu, U. Thorsteinsdóttir, K. Stefánsson, J. Dupuis, A. Morris, M. Boehnke, M. McCarthy, I. Prokopenko   +174 more
semanticscholar   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source