Results 111 to 120 of about 674,070 (352)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Chapter 11: Genome-Wide Association Studies

PLoS Computational Biology, 2012
Genome-wide association studies (GWAS) have evolved over the last ten years into a powerful tool for investigating the genetic architecture of human disease. In this work, we review the key concepts underlying GWAS, including the architecture of common diseases, the structure of common human genetic variation, technologies for capturing genetic ...
William S Bush, Jason H Moore
openaire   +4 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Genome-wide Association Study and Genomic Prediction for Fusarium graminearum Resistance Traits in Nordic Oat (Avena sativa L.) [PDF]

, 2020
Hanna Haikka, Outi Manninen, Juho Hautsalo, Leena Pietilä, Marja Jalli, Merja Veteläinen   +5 more
openalex   +1 more source

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

Nature Genetics, 2021
D. Wightman, I. Jansen, J. Savage, A. Shadrin, S. Bahrami, D. Holland, A. Rongve, S. Børte, B. Winsvold, O. K. Drange, Amy E. Martinsen, A. Skogholt, C. Willer, G. Bråthen, Ingunn Bosnes, J. Nielsen, L. Fritsche, Laurent F. Thomas, L. Pedersen, M. Gabrielsen, M. B. Johnsen, T. W. Meisingset, Wei Zhou, P. Proitsi, A. Hodges, Richard J. B. Dobson, L. Velayudhan, K. Heilbron, A. Auton, Michelle Stella Elizabeth Robert K. Jessica Katarzyna Emily Agee Aslibekyan Babalola Bell Bielenberg Bryc Bull, M. Agee, S. Aslibekyan, Elizabeth Babalola, R. Bell, Jessica Bielenberg, K. Bryc, Emily Bullis, Briana Cameron, D. Coker, Gabriel Cuellar Partida, Devika Dhamija, Sayantan Das, S. Elson, Teresa Filshtein, K. Fletez-Brant, P. Fontanillas, Will Freyman, P. Gandhi, B. Hicks, D. Hinds, K. Huber, E. Jewett, Yunxuan Jiang, A. Kleinman, Katelyn Kukar, Vanessa Lane, Keng-Han Lin, Maya Lowe, Marie K. Luff, J. McCreight, M. Mcintyre, K. McManus, Steven J. Micheletti, M. Moreno, J. Mountain, S. Mozaffari, P. Nandakumar, E. Noblin, Jared O’Connell, A. Petrakovitz, G. D. Poznik, Morgan Schumacher, Anjali J. Shastri, J. Shelton, Jingchunzi Shi, S. Shringarpure, C. Tian, Vinh Tran, J. Tung, Xin Wang, W. Wang, C. Weldon, Peter Wilton, J. Sealock, L. Davis, N. Pedersen, C. Reynolds, I. Karlsson, S. Magnússon, H. Stefánsson, Steinunn Thordardottir, P. Jonsson, J. Snaedal, A. Zettergren, I. Skoog, S. Kern, M. Waern, H. Zetterberg, K. Blennow, E. Stordal, K. Hveem, J. Zwart, L. Athanasiu, P. Selnes, I. Saltvedt, S. Sando, I. Ulstein, S. Djurovic, T. Fladby, D. Aarsland, G. Selbæk, S. Ripke, K. Stefánsson, O. Andreassen, D. Posthuma   +114 more
semanticscholar   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Examining the shared etiology of psychopathology with genome-wide association studies

, 2023
Travis T. Mallard, Andrew D. Grotzinger, Jordan W. Smoller   +2 more
openalex   +2 more sources

Genome-wide association studies with metabolomics [PDF]

Genome Medicine, 2012
Genome-wide association studies (GWAS) analyze the genetic component of a phenotype or the etiology of a disease. Despite the success of many GWAS, little progress has been made in uncovering the underlying mechanisms for many diseases. The use of metabolomics as a readout of molecular phenotypes has enabled the discovery of previously undetected ...
openaire   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women [PDF]

, 2010
Jill S. Barnholtz‐Sloan, Priya B. Shetty, Xiaowei Guan, Sarah J. Nyante, Jingchun Luo, Donal J. Brennan, Robert C. Millikan   +6 more
openalex   +1 more source