Results 121 to 130 of about 1,111,517 (383)

Advances in the genetics of myasthenia gravis: insights from cutting-edge neuroscience research

Frontiers in Medicine
Myasthenia gravis (MG) is an autoimmune disorder involving complex interactions between genetic and environmental factors. Genome-wide association studies (GWAS), transcriptome-wide association studies (TWAS), and other methods have identified multiple ...
Zheng Yixian, Wang Hai, Liu Xiuying, Yan Jichun   +3 more
doaj   +1 more source

A genome-wide association study of sleep habits and insomnia [PDF]

, 2013
Several aspects of sleep behavior such as timing, duration and quality have been demonstrated to be heritable. To identify common variants that influence sleep traits in the population, we conducted a genome-wide association study of six sleep phenotypes
Abe, Abecasis, Allebrandt, Amin, Aulchenko, Bastien, Beaulieu-Bonneau, Byrne, Chen, Dauvilliers, De Gennaro, Ferreira, Ford, Ge, Gottlieb, Green, Gregory, Hauri, Heath, Heath, Howie, Johns, Kantermann, Kripke, Lango Allen, Laposky, Lewis, Li, Liu, Luciano, McCarren, Medland, Ohayon, Partinen, Paunio, Purcell, Purcell, Reinscheid, Satake, Selbach, Serretti, Shimada, Soria, Speliotes, Utge, Viola, Visscher, Wellcome Trust Case Control, C, Willer, Wolk, Zhao   +50 more
core   +3 more sources

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

bioRxiv, 2019
Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype 1 – 3 . To identify novel loci, we performed a genome-wide association study including 133,384 breast cancer cases and 113,789 controls, plus 18,908 ...
Haoyu Zhang, T. Ahearn, J. Lecarpentier, D. Barnes, J. Beesley, Xia Jiang, T. O’Mara, Guanghao Qi, Ni Zhao, M. Bolla, A. Dunning, J. Dennis, Qin Wang, Z. Ful, K. Aittomäki, I. Andrulis, H. Anton-Culver, V. Arndt, K. Aronson, B. Arun, P. Auer, J. Azzollini, D. Barrowdale, H. Becher, M. Beckmann, S. Behrens, J. Benítez, M. Bermisheva, K. Białkowska, A. Blanco, C. Blomqvist, N. Bogdanova, S. Bojesen, B. Bonanni, Davide Bondavalli, Å. Borg, H. Brauch, H. Brenner, I. Briceño, A. Broeks, S. Brucker, T. Brüning, B. Burwinkel, S. Buys, H. Byers, T. Caldés, M. Caligo, M. Calvello, D. Campa, J. Castelao, J. Chang-Claude, S. Chanock, M. Christiaens, H. Christiansen, W. Chung, K. Claes, C. Clarke, S. Cornelissen, F. Couch, A. Cox, S. Cross, K. Czene, M. Daly, P. Devilee, O. Díez, S. Domchek, T. Dörk, M. Dwek, D. Eccles, A. Ekici, D. Evans, P. Fasching, J. Figueroa, L. Foretova, F. Fostira, E. Friedman, D. Frost, M. Gago-Domínguez, S. Gapstur, J. Garber, J. García-Saenz, M. Gaudet, S. Gayther, G. Giles, A. Godwin, M. Goldberg, D. Goldgar, A. González-Neira, M. Greene, J. Gronwald, P. Guénel, L. Häberle, E. Hahnen, C. Haiman, Christopher R. Hake, P. Hall, U. Hamann, E. Harkness, Bernadette A. M. Heemskerk-Gerritsen, P. Hillemanns, F. Hogervorst, B. Holleczek, A. Hollestelle, M. Hooning, R. Hoover, J. Hopper, A. Howell, H. Huebner, P. Hulick, E. Imyanitov, C. Isaacs, L. Izatt, A. Jager, M. Jakimovska, A. Jakubowska, P. James, R. Janavicius, W. Janni, E. John, Michael E. Jones, A. Jung, R. Kaaks, P. Kapoor, B. Karlan, R. Keeman, Sofia Khan, E. Khusnutdinova, C. Kitahara, Y. Ko, I. Konstantopoulou, L. Koppert, S. Koutros, V. Kristensen, A. Laenkholm, D. Lambrechts, S. Larsson, P. Laurent-Puig, C. Lázaro, E. Lazarova, F. Lejbkowicz, Goska Leslie, F. Lesueur, A. Lindblom, J. Lissowska, W. Lo, J. Loud, J. Lubiński, A. Lukomska, R. MacInnis, A. Mannermaa, M. Manoochehri, S. Manoukian, S. Margolin, M. Martínez, L. Matricardi, L. McGuffog, C. Mclean, Noura Mebirouk, A. Meindl, U. Menon, Austin Miller, E. Mingazheva, M. Montagna, A. Mulligan, C. Mulot, T. Muranen, K. Nathanson, S. Neuhausen, H. Nevanlinna, P. Neven, W. Newman, F. Nielsen, L. Nikitina-Zake, J. Nodora, K. Offit, E. Oláh, O. Olopade, H. Olsson, N. Orr, L. Papi, J. Papp, T. Park-Simon, M. Parsons, B. Peissel, Ana Peixoto, B. Peshkin, P. Peterlongo, J. Peto, K. Phillips, M. Piedmonte, D. Plaseska‐Karanfilska, Karolina Prajzendanc, R. Prentice, Darya Prokofyeva, B. Rack, P. Radice, S. Ramus, Johanna Rantala, M. Rashid, G. Rennert, H. Rennert, H. Risch, A. Romero, M. Rookus, M. Rübner, T. Rüdiger, E. Saloustros, S. Sampson, D. Sandler, E. Sawyer, M. Scheuner, R. Schmutzler, A. Schneeweiss, M. Schoemaker, B. Schöttker, P. Schürmann, L. Senter, Priyanka Sharma, M. Sherman, X. Shu, C. Singer, S. Smichkoska, P. Soucy, M. Southey, J. Spinelli, J. Stone, D. Stoppa-Lyonnet, A. Swerdlow, C. Szabo, R. Tamimi, W. Tapper, Jack A. Taylor, M. Teixeira, M. Terry, M. Thomassen, D. Thull, M. Tischkowitz, A. Toland, R. Tollenaar, I. Tomlinson, Diana Torres, M. Troester, Thérèse Truong, N. Tung, M. Untch, C. Vachon, A. V. D. van den Ouweland, L. E. van der Kolk, Elke M. van Veen, E. J. van Rensburg, A. Vega, B. Wappenschmidt, C. Weinberg, J. Weitzel, H. Wildiers, R. Winqvist, A. Wolk, Xiaohong R. Yang, D. Yannoukakos, W. Zheng, K. Zorn, M. Zuradelli, R. Milne, P. Kraft, J. Simard, P. Pharoah, K. Michailidou, A. Antoniou, M. Schmidt, G. Chenevix-Trench, D. Easton, M. García-Closas, N. Chatterjee   +272 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

A Large-Scale Genome-Wide Association Study in U.S. Holstein Cattle

Frontiers in Genetics, 2019
Genome-wide association study (GWAS) is a powerful approach to identify genomic regions and genetic variants associated with phenotypes. However, only limited mutual confirmation from different studies is available.
Jicai Jiang, Li Ma, Dzianis Prakapenka, P. Vanraden, J. Cole, Y. Da   +5 more
semanticscholar   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

A Genome-Wide Association Study for Calving Interval in Holstein Dairy Cows Using Weighted Single-Step Genomic BLUP Approach

Animals, 2020
The aim of the present study was to identify genomic region(s) associated with the length of the calving interval in primiparous (n = 6866) and multiparous (n = 5071) Holstein cows.
Hadi Atashi, Mazdak Salavati, Jenne De Koster, Mark A. Crowe, Geert Opsomer, Miel Hostens, The GplusE Consortium   +6 more
doaj   +1 more source

High-dimensional genome-wide association study and misspecified mixed model analysis

, 2014
We study behavior of the restricted maximum likelihood (REML) estimator under a misspecified linear mixed model (LMM) that has received much attention in recent gnome-wide association studies.
Jiang, Jiming, Li, Cong, Paul, Debashis, Yang, Can, Zhao, Hongyu   +4 more
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Genome-wide Association Study Identifies Two Susceptibility Loci for Osteosarcoma [PDF]

, 2014
Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. In order to better understand the genetic etiology of osteosarcoma, we performed a multi-stage genome-wide association study (GWAS) consisting of 941 cases and 3,291
Amary, Maria Fernanda, Andrulis, Irene L., Barkauskas, Donald A., Berndt, Sonja I., Caporaso, Neil E., Chanock, Stephen J., Chung, Charles C., de Toledo, Silvia Regina Caminada, Douglass, Chester, Flanagan, Adrienne M., Fraumeni, Joseph F., Gastier-Foster, Julie M., Gokgoz, Nalan, Gorlick, Richard, Halai, Dina, Hattinger, Claudia, Helman, Lee, Hoover, Robert N., Hunter, David J., Ilhan, Inci Ergurhan, Jacobs, Kevin, Khanna, Chand, Kogevinas, Manolis, Kraft, Peter, Kurucu, Nilgün, Landi, Maria Teresa, Lecanda, Fernando, Malats, Nuria, Marina, Neyssa, Meltzer, Paul S., Mirabello, Lisa, Patiño-Garcia, Ana, Petrilli, Antonio S., Picci, Piero, Purdue, Mark P., Rothman, Nathaniel, Sari, Neriman, Savage, Sharon A., Serra, Massimo, Sierrasesúmaga, Luis, Silverman, Debra T., Spector, Logan, Thomas, David M., Tirabosco, Roberto, Troisi, Rebecca, Tucker, Margaret, Wacholder, Sholom, Wang, Zhaoming, Wunder, Jay S., Yeager, Meredith   +49 more
core   +1 more source