Results 151 to 160 of about 1,111,517 (383)

Genetic parameter estimation and molecular foundation of chicken egg-laying trait

Poultry Science
: The age of first egg (AFE) in chicken can affect early and even life-time egg production performance to some extent, and therefore is an important economic trait that affects production efficiency.
Anqi Chen, Xiaoyu Zhao, Junhui Wen, Xiurong Zhao, Gang Wang, Xinye Zhang, Xufang Ren, Yalan Zhang, Xue Cheng, Xiaofan Yu, Xiaohan Mei, Huie Wang, Menghan Guo, Xiaoyu Jiang, Guozhen Wei, Xue Wang, Runshen Jiang, Xing Guo, Zhonghua Ning, Lujiang Qu   +19 more
doaj   +1 more source

Identification of a novel Parkinson’s disease locus via stratified genome-wide association study [PDF]

, 2014
Erin M. Hill‐Burns, William T. Wissemann, Taye H. Hamza, Stewart A. Factor, Cyrus P. Zabetian, Haydeh Payami   +5 more
openalex   +1 more source

Chapter 11: Genome-Wide Association Studies

PLoS Computational Biology, 2012
Genome-wide association studies (GWAS) have evolved over the last ten years into a powerful tool for investigating the genetic architecture of human disease. In this work, we review the key concepts underlying GWAS, including the architecture of common diseases, the structure of common human genetic variation, technologies for capturing genetic ...
William S Bush, Jason H Moore
openaire   +4 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

KNN-MDR: a learning approach for improving interactions mapping performances in genome wide association studies [PDF]

, 2017
Sinan Abo Alchamlat, Frédéric Farnir
openalex   +1 more source

Ancestry- and sex-specific effects underlying inguinal hernia susceptibility identified in a multiethnic genome-wide association study meta-analysis [PDF]

, 2022
Hélène Choquet, Weiyu Li, Jie Yin, Rachael Bradley, Thomas J Hoffmann, Priyanka Nandakumar, Rouzbeh Mostaedi, Chao Tian, Nadav Ahituv, Eric Jorgenson   +9 more
openalex   +1 more source

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

Nature Genetics, 2021
D. Wightman, I. Jansen, J. Savage, A. Shadrin, S. Bahrami, D. Holland, A. Rongve, S. Børte, B. Winsvold, O. K. Drange, Amy E. Martinsen, A. Skogholt, C. Willer, G. Bråthen, Ingunn Bosnes, J. Nielsen, L. Fritsche, Laurent F. Thomas, L. Pedersen, M. Gabrielsen, M. B. Johnsen, T. W. Meisingset, Wei Zhou, P. Proitsi, A. Hodges, Richard J. B. Dobson, L. Velayudhan, K. Heilbron, A. Auton, Michelle Stella Elizabeth Robert K. Jessica Katarzyna Emily Agee Aslibekyan Babalola Bell Bielenberg Bryc Bull, M. Agee, S. Aslibekyan, Elizabeth Babalola, R. Bell, Jessica Bielenberg, K. Bryc, Emily Bullis, Briana Cameron, D. Coker, Gabriel Cuellar Partida, Devika Dhamija, Sayantan Das, S. Elson, Teresa Filshtein, K. Fletez-Brant, P. Fontanillas, Will Freyman, P. Gandhi, B. Hicks, D. Hinds, K. Huber, E. Jewett, Yunxuan Jiang, A. Kleinman, Katelyn Kukar, Vanessa Lane, Keng-Han Lin, Maya Lowe, Marie K. Luff, J. McCreight, M. Mcintyre, K. McManus, Steven J. Micheletti, M. Moreno, J. Mountain, S. Mozaffari, P. Nandakumar, E. Noblin, Jared O’Connell, A. Petrakovitz, G. D. Poznik, Morgan Schumacher, Anjali J. Shastri, J. Shelton, Jingchunzi Shi, S. Shringarpure, C. Tian, Vinh Tran, J. Tung, Xin Wang, W. Wang, C. Weldon, Peter Wilton, J. Sealock, L. Davis, N. Pedersen, C. Reynolds, I. Karlsson, S. Magnússon, H. Stefánsson, Steinunn Thordardottir, P. Jonsson, J. Snaedal, A. Zettergren, I. Skoog, S. Kern, M. Waern, H. Zetterberg, K. Blennow, E. Stordal, K. Hveem, J. Zwart, L. Athanasiu, P. Selnes, I. Saltvedt, S. Sando, I. Ulstein, S. Djurovic, T. Fladby, D. Aarsland, G. Selbæk, S. Ripke, K. Stefánsson, O. Andreassen, D. Posthuma   +114 more
semanticscholar   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Genome-wide association studies with metabolomics [PDF]

Genome Medicine, 2012
Genome-wide association studies (GWAS) analyze the genetic component of a phenotype or the etiology of a disease. Despite the success of many GWAS, little progress has been made in uncovering the underlying mechanisms for many diseases. The use of metabolomics as a readout of molecular phenotypes has enabled the discovery of previously undetected ...
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source