Results 151 to 160 of about 674,070 (352)
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations
Nature Medicine, 2022 C. Tcheandjieu, Xiang Zhu, A. Hilliard, S. Clarke, V. Napolioni, Shining Ma, K. Lee, Huaying Fang, Fei Chen, Yingchang Lu, N. Tsao, S. Raghavan, S. Koyama, B. Gorman, M. Vujković, D. Klarin, M. Levin, Nasa Sinnott-Armstrong, G. Wojcik, M. Plomondon, T. Maddox, Stephen W. Waldo, A. Bick, S. Pyarajan, Jie Huang, Rebecca J Song, Y. Ho, S. Buyske, C. Kooperberg, J. Haessler, R. Loos, R. Do, M. Verbanck, K. Chaudhary, K. North, C. Avery, M. Graff, C. Haiman, L. Le Marchand, L. Wilkens, J. Bis, H. Leonard, Botong Shen, L. Lange, Ayush Giri, O. Dikilitas, I. Kullo, I. Stanaway, G. Jarvik, A. Gordon, S. Hebbring, B. Namjou, K. Kaufman, K. Ito, K. Ishigaki, Y. Kamatani, S. Verma, M. Ritchie, R. Kember, A. Baras, L. Lotta, S. Kathiresan, E. Hauser, Donald R Miller, Jennifer S. Lee, D. Saleheen, P. Reaven, Kelly Cho, J. Gaziano, P. Natarajan, J. Huffman, B. Voight, D. Rader, Kyong‐Mi Chang, J. Lynch, S. Damrauer, P. Wilson, Hua Tang, Yan V. Sun, P. Tsao, C. O’Donnell, T. Assimes +81 moresemanticscholar +1 more sourceClass IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio +13 morewiley +1 more sourceIn vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow +10 morewiley +1 more sourceTwo New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups
, 2010 André Scherag, Christian Dina, Anke Hinney, Vincent Vatin, Susann Scherag, Carla Ivane Ganz Vogel, Timo D. Müller, Harald Grallert, H.‐Erich Wichmann, Beverley Balkau, Barbara Heude, Marjo‐Riitta Järvelin, Anna‐Liisa Hartikainen, Claire Lévy‐Marchal, Jacques Weill, Jérôme Delplanque, Antje Körner, Wieland Kieß, Péter Kovács, Nigel W. Rayner, Inga Prokopenko, Mark I. McCarthy, H. Schäfer, Ivonne Jarick, Heiner Boeing, Eva Fisher, Thomas Reinehr, Joachim Heinrich, Peter Rzehak, Dietrich Berdel, Michael Borte, Heike Biebermann, Heiko Krude, Dieter Rosskopf, Christian Rimmbach, Winfried Rief, Tobias Fromme, Martin Klingenspor, Annette Schürmann, Nadja Schulz, Markus M. Nöthen, Hae‐Won Uh, Raimund Erbel, Karl‐Heinz Jöckel, Susanne Moebus, Tanja Boes, Thomas Illig, Philippe Froguel, Johannes Hebebrand, Stephen Eyre +49 moreopenalex +2 more sourcesGenome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
Nature Genetics, 2007 J. Rioux, J. Rioux, R. Xavier, K. Taylor, M. Silverberg, P. Goyette, A. Huett, Todd Green, Petric Kuballa, M. Barmada, L. Datta, Y. Shugart, A. Griffiths, S. Targan, A. Ippoliti, E. Bernard, L. Mei, Dan L. Nicolae, M. Regueiro, L. P. Schumm, A. Steinhart, J. Rotter, R. Duerr, Judy H. Cho, M. J. Daly, M. J. Daly, S. Brant +26 moresemanticscholar +1 more sourceEffect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees +6 morewiley +1 more source
