Results 51 to 60 of about 685,002 (338)

Genomic characterization and phylogenetic analysis of Salmonella enterica serovar Javiana [PDF]

PeerJ, 2020
Salmonella enterica serovar Javiana is the fourth most reported serovar of laboratory-confirmed human Salmonella infections in the U.S. and in Tennessee (TN). Although Salmonella ser.
Lauren K. Hudson, Lisha Constantine-Renna, Linda Thomas, Christina Moore, Xiaorong Qian, Katie Garman, John R. Dunn, Thomas G. Denes   +7 more
doaj   +2 more sources

Genome-wide association study and meta-analysis finds over 40 loci affect risk of type 1 diabetes

Nature Genetics, 2009
Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously ...
J. Barrett, David G. Clayton, Patrick Concannon, B. Akolkar, Jason D Cooper, Henry A Erlich, Cécile Julier, Grant Morahan, Jørn Nerup, Concepcion Nierras, Vincent Plagnol, F. Pociot, Helen Schuilenburg, D. Smyth, H. Stevens, John A. Todd, N. Walker, Stephen S Rich   +17 more
semanticscholar   +1 more source

A genome-wide association study of aging

Neurobiology of Aging, 2011
Human longevity and healthy aging show moderate heritability (20%-50%). We conducted a meta-analysis of genome-wide association studies from 9 studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium for 2 outcomes: (1) all-cause mortality, and (2) survival free of major disease or death.
Jerome I. Rotter, Eric Boerwinkle, Douglas P. Kiel, Michelle Shardell, Yongmei Liu, Ellen W. Demerath, Philip L. De Jager, M. Carola Zillikens, Cornelia M. van Duijn, Lenore J. Launer, Stefania Bandinelli, Jeremy D. Walston, Sudha Seshadri, Sudha Seshadri, Henning Tiemeier, Sebastian E. Baumeister, Toshiko Tanaka, Nora Franceschini, Tamara B. Harris, Denis A. Evans, Mika Kivimäki, Eric M. Reiman, Thomas Kocher, Luigi Ferrucci, Albert V. Smith, Wolfgang Hoffmann, Wolfgang Hoffmann, Pamela L. Lutsey, Aron S. Buchman, Gregory J. Tranah, Kathryn L. Lunetta, Joanne M. Murabito, Joanne M. Murabito, Emelia J. Benjamin, Emelia J. Benjamin, Meena Kumari, Albert Hofman, Stefan Walter, Gil Atzmon, Maris Kuningas, Reiner Biffar, Anne B. Newman, David A. Bennett, David Couper, Yuri Milaneschi, Robert C. Kaplan, Melissa E. Garcia, David Karasik, Johan P. Mackenbach, Kristin D. Marciante, Kurt Lohman, Uwe Völker, Vilmundur Gudnason, Lei Yu, Bruce M. Psaty, Bruce M. Psaty, Alice M. Arnold   +56 more
openaire   +4 more sources

Exploring quantitative traits-associated copy number deletions through reanalysis of UK10K consortium whole genome sequencing cohorts

BMC Genomics, 2023
Objectives We performed comprehensive association analyses of common high-confidence gnomAD-reported copy number deletions (CNDs) with 60 quantitative traits from UK10K consortium WGS data.
Sejoon Lee, Jinho Kim, Jung Hun Ohn
doaj   +1 more source

Genome-wide Association Studies

, 2013
Genome-wide association studies (GWAS) are a powerful hypothesis-free tool for the dissection of susceptibility to common heritable human diseases, including osteoporosis. To date, more than 10,000 loci for common human diseases and traits have been identified by GWAS; and it is hard to think of a methodological breakthrough in recent times that has ...
Duncan, Emma, Brown, Matthew
openaire   +3 more sources

Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease [PDF]

, 2011
We present the first application of the hypothesis-rich mathematical theory to genome-wide association data. The Hamza et al. late-onset sporadic Parkinson's disease genome-wide association study dataset was analyzed.
A Lerner, A Ruepp, AA Merchant, AM Glazer, B Bakir-Gungor, B Dass, C Wolff, CB Do, CH Hawkes, D Subramaniam, DAD Monte, DI Chasman, E Eskin, FL Moore, H-C Fung, HR Kim, J Simón-Sánchez, K Lai, K Roeder, K Roeder, K Roeder, K Sekimizu, K Tsuboi, L Lum, LA Hindorff, LM Bekris, M Bak, M Plaisant, M Saad, M-X Li, N Miao, O Bragina, P Mill, P Whitton, PA Beachy, PW Ingham, RE Lamont, S Purcell, SM Chambers, SY Tay, TA Manolio, TH Hamza, TL Edwards, TS Keshava Prasad, V Palma, VF Rafuse, W Satake, Y Katoh   +47 more
core   +3 more sources

Genome-Wide Association Studies of Cancer [PDF]

Journal of Clinical Oncology, 2010
Knowledge of the inherited risk for cancer is an important component of preventive oncology. In addition to well-established syndromes of cancer predisposition, much remains to be discovered about the genetic variation underlying susceptibility to common malignancies.
Mark E. Robson, Zsofia K. Stadler, Bert Gold, Peter Thom, Noah D. Kauff, Karen Hurley, Vincent Devlin, Jeffrey N. Weitzel, Kenneth Offit, Robert J. Klein   +9 more
openaire   +2 more sources

Genome-Wide Association Study of Hepatitis in Korean Populations [PDF]

Genomics & Informatics, 2014
Hepatitis is a common and serious disease for the Korean population. It is caused by a virus, the A and B types of which are plentiful in Koreans. In this study, we tried to find genetic factors for hepatitis through genome-wide association studies.
Youngbok Hong, Sejong Oh
doaj   +1 more source

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration [PDF]

, 2011
AIMS: To evaluate the associations of emergent genome-wide-association study-derived coronary heart disease (CHD)-associated single nucleotide polymorphisms (SNPs) with established and emerging risk factors, and the association of genome-wide-association
Angelakopoulou, A, Berry, DJ, Casas, JP, Caulfield, M, Cooper, J, de Faire, U, Deanfield, J, Drenos, F, Fowkes, FG, Gigante, B, Hardy, R, Hingorani, AD, Humphries, SE, Hypponen, E, Ireland, H, Jefferis, BJ, Kivimaki, M, Kuh, D, Kumari, M, Lathrop, M, Laxton, RC, Leander, K, Maniatis, N, Marmot, M, Morris, RW, Motterle, A, Munroe, PB, Palmen, J, Power, C, Price, J, Samani, N, Shah, S, Shah, T, Simpson, IA, Smeeth, L, Sofat, R, Talmud, PJ, Thomson, A, Tzoulaki, I, Verzilli, C, Wallace, C, Whincup, PH, Whittaker, JC, Wong, A, Ye, S   +44 more
core   +3 more sources

Genome-wide Association Study for AKI

Kidney360, 2023
Key Points Two genetic variants in the DISP1-TLR5 gene locus were associated with risk of AKI.DISP1 and TLR5 were differentially regulated in kidney biopsy tissue from patients with AKI compared with no AKI. Background
Pavan K. Bhatraju, Ian B. Stanaway, Melody R. Palmer, Rajasree Menon, Jennifer A. Schaub, Steven Menez, Anand Srivastava, F. Perry Wilson, Krzysztof Kiryluk, Paul M. Palevsky, Abhijit S. Naik, Sana S. Sakr, Gail P. Jarvik, Chirag R. Parikh, Lorraine B. Ware, T. Alp Ikizler, Edward D. Siew, Vernon M. Chinchilli, Steve G. Coca, Amit X. Garg, Alan S. Go, James S. Kaufman, Paul L. Kimmel, Jonathan Himmelfarb, Mark M. Wurfel   +24 more
openaire   +2 more sources