Results 51 to 60 of about 1,051,148 (367)
Genome-wide association study identifies 74 loci associated with educational attainment
Nature, 2016 Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals.A. Okbay, J. Beauchamp, M. Fontana, James J. Lee, T. Pers, C. A. Rietveld, P. Turley, Guo-Bo Chen, V. Emilsson, S. Meddens, Sven Oskarsson, Joseph K. Pickrell, Kevin Thom, P. Timshel, Ronald de Vlaming, A. Abdellaoui, T. Ahluwalia, J. Bacelis, C. Baumbach, G. Bjornsdottir, J. Brandsma, Maria Pina Concas, J. Derringer, N. Furlotte, T. Galesloot, G. Girotto, Richa Gupta, Leanne M. Hall, S. Harris, E. Hofer, M. Horikoshi, J. Huffman, Kadri Kaasik, I. Kalafati, R. Karlsson, A. Kong, J. Lahti, S. J. Lee, C. deLeeuw, P. Lind, K. Lindgren, Tian Liu, M. Mangino, J. Marten, E. Mihailov, Michael B. Miller, Peter J. van der Most, C. Oldmeadow, A. Payton, N. Pervjakova, W. Peyrot, Yong Qian, O. Raitakari, R. Rueedi, E. Salvi, B. Schmidt, Katharina E. Schraut, Jianxin Shi, A. Smith, R. Poot, Beate St Pourcain, A. Teumer, G. Thorleifsson, N. Verweij, D. Vuckovic, J. Wellmann, H. Westra, Jingyun Yang, Wei Zhao, Zhihong Zhu, B. Alizadeh, N. Amin, A. Bakshi, S. Baumeister, G. Biino, K. Bønnelykke, P. Boyle, H. Campbell, F. Cappuccio, G. Davies, J. De Neve, P. Deloukas, I. Demuth, Jun Ding, P. Eibich, L. Eisele, N. Eklund, David M. Evans, J. Faul, M. Feitosa, A. Forstner, I. Gandin, Bjarni Gunnarsson, B. Halldórsson, T. Harris, Andrew C. Heath, L. Hocking, Elizabeth G. Holliday, G. Homuth, M. Horan, J. Hottenga, P. De Jager, Peter K. Joshi, A. Jugessur, M. Kaakinen, M. Kähönen, S. Kanoni, Liisa Keltigangas-Järvinen, L. Kiemeney, I. Kolčić, S. Koskinen, A. Kraja, M. Kroh, Z. Kutalik, A. Latvala, L. Launer, Maël P. Lebreton, D. Levinson, P. Lichtenstein, P. Lichtner, D. Liewald, LifeLines Cohort Study, A. Loukola, P. Madden, R. Mägi, T. Mäki-Opas, R. Marioni, P. Marques-Vidal, Gerardus A. Meddens, George Mcmahon, C. Meisinger, T. Meitinger, Y. Milaneschi, L. Milani, G. Montgomery, Ronny Myhre, C. Nelson, D. Nyholt, William E. R. Ollier, A. Palotie, L. Paternoster, Nancy L Pedersen, K. Petrovic, D. Porteous, K. Räikkönen, Susan M. Ring, A. Robino, Olga Rostapshova, I. Rudan, A. Rustichini, V. Salomaa, A. Sanders, Antti-Pekka Sarin, H. Schmidt, Rodney J Scott, Blair H. Smith, Jennifer A Smith, J. Staessen, E. Steinhagen-Thiessen, K. Strauch, A. Terracciano, M. Tobin, Sheila Ulivi, S. Vaccargiu, L. Quaye, F. V. van Rooij, C. Venturini, Anna A. E. Vinkhuyzen, U. Völker, H. Völzke, J. Vonk, D. Vozzi, Johannes Waage, E. Ware, G. Willemsen, J. Attia, David A. Bennett, K. Berger, L. Bertram, H. Bisgaard, D. Boomsma, I. Borecki, Ute Bültmann, C. Chabris, F. Cucca, D. Cusi, I. Deary, G. Dedoussis, C. V. van Duijn, J. Eriksson, B. Franke, L. Franke, P. Gasparini, P. Gejman, C. Gieger, H. Grabe, J. Gratten, Patrick J. F. Groenen, V. Gudnason, P. van der Harst, C. Hayward, D. Hinds, W. Hoffmann, E. Hyppönen, W. Iacono, B. Jacobsson, M. Järvelin, K. Jöckel, J. Kaprio, S. Kardia, T. Lehtimäki, Steven F. Lehrer, P. Magnusson, Nicholas G. Martin, M. McGue, A. Metspalu, N. Pendleton, B. Penninx, M. Perola, N. Pirastu, M. Pirastu, O. Polašek, D. Posthuma, C. Power, M. Province, Nilesh J. Samani, D. Schlessinger, R. Schmidt, T. I. Sørensen, T. Spector, K. Stefánsson, U. Thorsteinsdóttir, A. Thurik, N. Timpson, H. Tiemeier, J. Tung, A. Uitterlinden, V. Vitart, P. Vollenweider, David R. Weir, James F. Wilson, Alan F. Wright, Dalton C. Conley, Robert F. Krueger, G. Davey Smith, A. Hofman, D. Laibson, S. Medland, M. Meyer, Jian Yang, M. Johannesson, P. Visscher, T. Esko, P. Koellinger, D. Cesarini, D. Benjamin +255 moresemanticscholar +1 more sourceReplication in Genome-Wide Association Studies
Statistical Science, 2009 Replication helps ensure that a genotype-phenotype association observed in a genome-wide association (GWA) study represents a credible association and is not a chance finding or an artifact due to uncontrolled biases. We discuss prerequisites for exact replication, issues of heterogeneity, advantages and disadvantages of different methods of data ...Kraft, Peter, Zeggini, Eleftheria, Ioannidis, John P. A. +2 moreopenaire +6 more sourcesA large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure. [PDF]
, 2017 Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, a leading cause of blindness. IOP heritability has been estimated to up to 67%, and to date only 11 IOP loci have been reported, accounting for 1.5% of IOP variability.Banda, Yambazi, Choquet, Hélène, Hoffmann, Thomas J, Jorgenson, Eric, Kvale, Mark N, Melles, Ronald, Nair, K Saidas, Risch, Neil, Schaefer, Catherine, Thai, Khanh K, Yin, Jie +10 morecore +3 more sourcesGenome-wide association study and meta-analysis finds over 40 loci affect risk of type 1 diabetes
Nature Genetics, 2009 Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously ...J. Barrett, David G. Clayton, Patrick Concannon, B. Akolkar, Jason D Cooper, Henry A Erlich, Cécile Julier, Grant Morahan, Jørn Nerup, Concepcion Nierras, Vincent Plagnol, F. Pociot, Helen Schuilenburg, D. Smyth, H. Stevens, John A. Todd, N. Walker, Stephen S Rich +17 moresemanticscholar +1 more sourceA genome-wide association study of aging
Neurobiology of Aging, 2011 Human longevity and healthy aging show moderate heritability (20%-50%). We conducted a meta-analysis of genome-wide association studies from 9 studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium for 2 outcomes: (1) all-cause mortality, and (2) survival free of major disease or death.Jerome I. Rotter, Eric Boerwinkle, Douglas P. Kiel, Michelle Shardell, Yongmei Liu, Ellen W. Demerath, Philip L. De Jager, M. Carola Zillikens, Cornelia M. van Duijn, Lenore J. Launer, Stefania Bandinelli, Jeremy D. Walston, Sudha Seshadri, Sudha Seshadri, Henning Tiemeier, Sebastian E. Baumeister, Toshiko Tanaka, Nora Franceschini, Tamara B. Harris, Denis A. Evans, Mika Kivimäki, Eric M. Reiman, Thomas Kocher, Luigi Ferrucci, Albert V. Smith, Wolfgang Hoffmann, Wolfgang Hoffmann, Pamela L. Lutsey, Aron S. Buchman, Gregory J. Tranah, Kathryn L. Lunetta, Joanne M. Murabito, Joanne M. Murabito, Emelia J. Benjamin, Emelia J. Benjamin, Meena Kumari, Albert Hofman, Stefan Walter, Gil Atzmon, Maris Kuningas, Reiner Biffar, Anne B. Newman, David A. Bennett, David Couper, Yuri Milaneschi, Robert C. Kaplan, Melissa E. Garcia, David Karasik, Johan P. Mackenbach, Kristin D. Marciante, Kurt Lohman, Uwe Völker, Vilmundur Gudnason, Lei Yu, Bruce M. Psaty, Bruce M. Psaty, Alice M. Arnold +56 moreopenaire +4 more sourcesGenome-wide Association Studies
, 2013 Genome-wide association studies (GWAS) are a powerful hypothesis-free tool for the dissection of susceptibility to common heritable human diseases, including osteoporosis. To date, more than 10,000 loci for common human diseases and traits have been identified by GWAS; and it is hard to think of a methodological breakthrough in recent times that has ...Duncan, Emma, Brown, Matthewopenaire +3 more sourcesGenome-wide Association Study for AKI
Kidney360, 2023 Key Points Two genetic variants in the DISP1-TLR5 gene locus were associated with risk of AKI.DISP1 and TLR5 were differentially regulated in kidney biopsy tissue from patients with AKI compared with no AKI. Background Pavan K. Bhatraju, Ian B. Stanaway, Melody R. Palmer, Rajasree Menon, Jennifer A. Schaub, Steven Menez, Anand Srivastava, F. Perry Wilson, Krzysztof Kiryluk, Paul M. Palevsky, Abhijit S. Naik, Sana S. Sakr, Gail P. Jarvik, Chirag R. Parikh, Lorraine B. Ware, T. Alp Ikizler, Edward D. Siew, Vernon M. Chinchilli, Steve G. Coca, Amit X. Garg, Alan S. Go, James S. Kaufman, Paul L. Kimmel, Jonathan Himmelfarb, Mark M. Wurfel +24 moreopenaire +2 more sourcesGenome-wide association study of receptive language ability of 12 year olds [PDF]
, 2013 Purpose: We have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. The current study attempted to identify some of the genes responsible for the heritability of receptive language ...Claire M. A. Haworth, Emma L. Meaburn, Hammill D. D., Ken B. Hanscombe, Kovas Y., Maciej Trzaskowski, Marianna E. Hayiou-Thomas, Nicole Harlaar, Nippold M. A., Oliver S. P. Davis, Philip S. Dale, Plomin R., Plomin R., Robert Plomin, Sophia Docherty, Thomas S. Price, Wechsler D., Wiig E. H. +17 morecore +3 more sourcesGenome-wide Association Study of Chicken Plumage Pigmentation [PDF]
Asian-Australasian Journal of Animal Sciences, 2013 To increase plumage color uniformity and understand the genetic background of Korean chickens, we performed a genome-wide association study of different plumage color in Korean native chickens. We analyzed 60K SNP chips on 279 chickens with GEMMA methods Mi Na Park, Jin Ae Choi, Kyung-Tai Lee, Hyun-Jeong Lee, Bong-Hwan Choi, Heebal Kim, Tae-Hun Kim, Seoae Cho, Taeheon Lee +8 moredoaj +1 more source
