Results 51 to 60 of about 1,111,517 (383)

Genetic Pathways to Insomnia

Brain Sciences, 2016
This review summarizes current research on the genetics of insomnia, as genetic contributions are thought to be important for insomnia etiology. We begin by providing an overview of genetic methods (both quantitative and measured gene), followed by a ...
Mackenzie J. Lind, Philip R. Gehrman
doaj   +1 more source

Meta-Analysis of Genome-Wide Linkage Studies in Celiac Disease. [PDF]

, 2009
OBJECTIVE: A meta-analysis of genome-wide linkage studies allows us to summarize the extensive information available from family-based studies, as the field moves into genome-wide association studies. METHODS: Here we apply the genome scan meta-analysis
Babron MC, Ciclitira PJ, Forabosco P, GRECO, LUIGI, Houlston RS, Lewis C.M., Naluai AT, Neuhausen SL, Saavalainen P, Wijmenga C   +9 more
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Exploring quantitative traits-associated copy number deletions through reanalysis of UK10K consortium whole genome sequencing cohorts

BMC Genomics, 2023
Objectives We performed comprehensive association analyses of common high-confidence gnomAD-reported copy number deletions (CNDs) with 60 quantitative traits from UK10K consortium WGS data.
Sejoon Lee, Jinho Kim, Jung Hun Ohn
doaj   +1 more source

A genome-wide association study of anorexia nervosa. [PDF]

, 2014
Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results.
A A van Elburg, A Bruson, A Farmer, A Favaro, A Hinney, A Julia, A Karwautz, A Keski-Rahkonen, A Lundervold, A Metspalu, A Palotie, A Raevuori, A Rajewski, A S Kaplan, A Scherag, A Schosser, A Slopien, A Tortorella, A Tsitsika, A Versini, Adrian Hill, Alexander P Maxwell, Anna Dominiczak, Audrey Duncanson, B Ding, B Herpertz-Dahlmann, B P C Koeleman, C Boni, C de Kovel, C Dina, C E Hilliard, C Finan, C M Bulik, C M Lewis, C S Franklin, C Taico, Carl A Anderson, Christopher S Franklin, Cordelia Langford, Cordelia Langford, Cynthia M Bulik, D A Collier, D Degortes, D Dikeos, D Koubek, D Li, D M Dick, D Martaskova, D Pinto, D Rujescu, D W Logan, David A Collier, David P Strachan, Douglas Simpkin, E Docampo, E F Van Furth, E Merl, E Strengman, E Tenconi, E Widén, E Zeggini, Eleftheria Zeggini, Emma Gray, F Fernández-Aranda, F Gonidakis, F Rybakowski, F Tozzi, Fredrik O Vannberg, G Breen, G Dedoussis, G Escaramís, G Gambaro, G Kalsi, G Komaki, G P S Knudsen, G R S Ritchie, G Wagner, Graeme Alexander, Graham Lord, H Aschauer, H Hakonarson, H Imgart, H Inoko, H Papezova, H-E Wichmann, Hannah Blackburn, I Giegling, I Jaussent, I Meulenbelt, I Ntalla, I Reinvang, I Tachmazidou, J A B Floyd, J C Barrett, J Dackor, J E DeSocio, J H Baker, J Hauser, J Hebebrand, J Hendriks, J Huemer, J I Hudson, J K O'Toole, J Kaprio, J L Kennedy, J Lissowska, J P Szatkiewicz, J Pantel, J Treasure, James A B Floyd, Jeffrey C Barrett, Jeffrey C Barrett, Jennifer Sambrook, Jonathan Stephens, K Bühren, K Egberts, K Fischer, K Kiezebrink, K L Klump, K Männik, K Tziouvas, L Alfredsson, L Carlberg, L Foretova, L Karhunen, L Klareskog, L M Huckins, L M Thornton, L Padyukov, L Peltonen, L Slachtova, L Southam, Leena Peltonen, Linda Morgan, M C T Slof-Op 't Landt, M Clementi, M de Zwaan, M Dmitrzak-Weglarz, M Forzan, M Gratacos, M J H Kas, M K Brandys, M Maj, M Mattingsdal, M Navratilova, M Roberts, Mathew Gillman, N J Schork, N Ramoz, N Soranzo, N Szeszenia-Dabrowska, N W Rayner, Neil Sheerin, Nicole Soranzo, Nicole Soranzo, null null, O A Andreassen, O S P Davis, P Courtet, P E Slagboom, P F Sullivan, P Gorwood, P Lichtenstein, P McGuffin, P Monteleone, P Santonastaso, Pamela Whittaker, Peter J Conlon, R A H Adan, R A Ophoff, R Burghardt, R D Cone, R D Levitan, R Rabionet, R Sladek, Ralph McGinnis, Richard N Sandford, S Cichon, S Cohen-Woods, S E Trace, S Ehrlich, S Gallinger, S Guillaume, S Helder, S Herms, S Jiménez-Murcia, S Le Hellard, S Marsal, S Ripatti, S Scherag, S Schreiber, S W Scherer, S Zerwas, S Zipfel, Sarah E Hunt, Sarah Edkins, Simon Potter, Stephen S Rich, Suna Onengut-Gumuscu, Susan M Ring, T Ando, T Esko, T Espeseth, T Reichborn-Kjennerud, U N Danner, U Schmidt, V Bencko, V Boraska, V Gaborieau, V Janout, V M Steen, W H Berrettini, W Herzog, Wei-Min Chen, Wendy L McArdle, Willem H Ouwehand, X Estivill, Y Guo, Z Yilmaz   +218 more
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Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration [PDF]

, 2011
AIMS: To evaluate the associations of emergent genome-wide-association study-derived coronary heart disease (CHD)-associated single nucleotide polymorphisms (SNPs) with established and emerging risk factors, and the association of genome-wide-association
Angelakopoulou, A, Berry, DJ, Casas, JP, Caulfield, M, Cooper, J, de Faire, U, Deanfield, J, Drenos, F, Fowkes, FG, Gigante, B, Hardy, R, Hingorani, AD, Humphries, SE, Hypponen, E, Ireland, H, Jefferis, BJ, Kivimaki, M, Kuh, D, Kumari, M, Lathrop, M, Laxton, RC, Leander, K, Maniatis, N, Marmot, M, Morris, RW, Motterle, A, Munroe, PB, Palmen, J, Power, C, Price, J, Samani, N, Shah, S, Shah, T, Simpson, IA, Smeeth, L, Sofat, R, Talmud, PJ, Thomson, A, Tzoulaki, I, Verzilli, C, Wallace, C, Whincup, PH, Whittaker, JC, Wong, A, Ye, S   +44 more
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Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

Nature Genetics, 2016
Genetic association studies have identified 215 risk loci for inflammatory bowel disease, thereby uncovering fundamental aspects of its molecular biology.
K. D. de Lange, L. Moutsianas, James C. Lee, C. Lamb, Yang Luo, N. Kennedy, L. Jostins, D. Rice, Javier Gutiérrez-Achury, S. Ji, G. Heap, E. Nimmo, C. Edwards, P. Henderson, C. Mowat, J. Sanderson, J. Satsangi, A. Simmons, D. Wilson, M. Tremelling, A. Hart, C. Mathew, W. Newman, M. Parkes, C. Lees, H. Uhlig, C. Hawkey, N. Prescott, T. Ahmad, J. Mansfield, C. Anderson, J. Barrett   +31 more
semanticscholar   +1 more source

Identification and validation of novel risk genes for intervertebral disc disorder by integrating large-scale multi-omics analyses and experimental studies

Frontiers in Medicine
IntroductionAlthough genome-wide association studies (GWAS) have identified multiple genetic loci linked to intervertebral disc disorder (IDD), their functional characterization remains largely unelucidated.
Zhe Zhang, Zhe Zhang, Yu Chen, Qianjin Wang, Zheng Li, Bingyang Dai, Bingyang Dai, Cheng Dong, Cheng Dong, Zhengya Zhu   +9 more
doaj   +1 more source

Genome-wide association study of behavioural and psychiatric features in human prion disease. [PDF]

, 2015
Prion diseases are rare neurodegenerative conditions causing highly variable clinical syndromes, which often include prominent neuropsychiatric symptoms.
Carswell, C, Collinge, J, Lowe, J, Lukic, A, MacKay, A, Mead, S, Porter, MC, Rudge, P, Thompson, AG, Uphill, J   +9 more
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A genomic‐based vision on the genetic diversity and key performance traits in selectively bred Arctic charr (Salvelinus alpinus)

Evolutionary Applications, 2022
Routine implementation of genomic information for guiding selection decisions is not yet common in the majority of aquaculture species. Reduced representation sequencing approaches offer a cost‐effective solution for obtaining genome‐wide information in ...
Christos Palaiokostas, Anam Anjum, Henrik Jeuthe, Khrystyna Kurta, Fernando Lopes Pinto, Dirk Jan deKoning   +5 more
doaj   +1 more source

A genome-wide association study of self-rated health [PDF]

, 2010
Self-rated health questions have been proven to be a highly reliable and valid measure of overall health as measured by other indicators in many population groups.
Gordon, Scott D, Heath, Andrew C, Madden, Pamela A, Martin, Nicholas G, Medland, Sarah E, Montgomery, Grant W, Mosing, Miriam A, Painter, Jodie, Verweij, Karin J.H.   +8 more
core   +2 more sources