Results 81 to 90 of about 674,070 (352)

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Genome-wide association studies identify novel genetic loci for epigenetic age acceleration among survivors of childhood cancer [PDF]

, 2022
Qian Dong, Nan Song, Na Qin, Cheng Chen, Zhenghong Li, Xiaojun Sun, John Easton, Heather L. Mulder, Emily M. Plyler, Geoffrey Neale, Emily Walker, Qian Li, Xiaotu Ma, Xiang Chen, I‐Chan Huang, Yutaka Yasui, Kirsten K. Ness, Jinghui Zhang, Melissa M. Hudson, Leslie L. Robison, Zhaoming Wang   +20 more
openalex   +1 more source

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

bioRxiv, 2019
Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype 1 – 3 . To identify novel loci, we performed a genome-wide association study including 133,384 breast cancer cases and 113,789 controls, plus 18,908 ...
Haoyu Zhang, T. Ahearn, J. Lecarpentier, D. Barnes, J. Beesley, Xia Jiang, T. O’Mara, Guanghao Qi, Ni Zhao, M. Bolla, A. Dunning, J. Dennis, Qin Wang, Z. Ful, K. Aittomäki, I. Andrulis, H. Anton-Culver, V. Arndt, K. Aronson, B. Arun, P. Auer, J. Azzollini, D. Barrowdale, H. Becher, M. Beckmann, S. Behrens, J. Benítez, M. Bermisheva, K. Białkowska, A. Blanco, C. Blomqvist, N. Bogdanova, S. Bojesen, B. Bonanni, Davide Bondavalli, Å. Borg, H. Brauch, H. Brenner, I. Briceño, A. Broeks, S. Brucker, T. Brüning, B. Burwinkel, S. Buys, H. Byers, T. Caldés, M. Caligo, M. Calvello, D. Campa, J. Castelao, J. Chang-Claude, S. Chanock, M. Christiaens, H. Christiansen, W. Chung, K. Claes, C. Clarke, S. Cornelissen, F. Couch, A. Cox, S. Cross, K. Czene, M. Daly, P. Devilee, O. Díez, S. Domchek, T. Dörk, M. Dwek, D. Eccles, A. Ekici, D. Evans, P. Fasching, J. Figueroa, L. Foretova, F. Fostira, E. Friedman, D. Frost, M. Gago-Domínguez, S. Gapstur, J. Garber, J. García-Saenz, M. Gaudet, S. Gayther, G. Giles, A. Godwin, M. Goldberg, D. Goldgar, A. González-Neira, M. Greene, J. Gronwald, P. Guénel, L. Häberle, E. Hahnen, C. Haiman, Christopher R. Hake, P. Hall, U. Hamann, E. Harkness, Bernadette A. M. Heemskerk-Gerritsen, P. Hillemanns, F. Hogervorst, B. Holleczek, A. Hollestelle, M. Hooning, R. Hoover, J. Hopper, A. Howell, H. Huebner, P. Hulick, E. Imyanitov, C. Isaacs, L. Izatt, A. Jager, M. Jakimovska, A. Jakubowska, P. James, R. Janavicius, W. Janni, E. John, Michael E. Jones, A. Jung, R. Kaaks, P. Kapoor, B. Karlan, R. Keeman, Sofia Khan, E. Khusnutdinova, C. Kitahara, Y. Ko, I. Konstantopoulou, L. Koppert, S. Koutros, V. Kristensen, A. Laenkholm, D. Lambrechts, S. Larsson, P. Laurent-Puig, C. Lázaro, E. Lazarova, F. Lejbkowicz, Goska Leslie, F. Lesueur, A. Lindblom, J. Lissowska, W. Lo, J. Loud, J. Lubiński, A. Lukomska, R. MacInnis, A. Mannermaa, M. Manoochehri, S. Manoukian, S. Margolin, M. Martínez, L. Matricardi, L. McGuffog, C. Mclean, Noura Mebirouk, A. Meindl, U. Menon, Austin Miller, E. Mingazheva, M. Montagna, A. Mulligan, C. Mulot, T. Muranen, K. Nathanson, S. Neuhausen, H. Nevanlinna, P. Neven, W. Newman, F. Nielsen, L. Nikitina-Zake, J. Nodora, K. Offit, E. Oláh, O. Olopade, H. Olsson, N. Orr, L. Papi, J. Papp, T. Park-Simon, M. Parsons, B. Peissel, Ana Peixoto, B. Peshkin, P. Peterlongo, J. Peto, K. Phillips, M. Piedmonte, D. Plaseska‐Karanfilska, Karolina Prajzendanc, R. Prentice, Darya Prokofyeva, B. Rack, P. Radice, S. Ramus, Johanna Rantala, M. Rashid, G. Rennert, H. Rennert, H. Risch, A. Romero, M. Rookus, M. Rübner, T. Rüdiger, E. Saloustros, S. Sampson, D. Sandler, E. Sawyer, M. Scheuner, R. Schmutzler, A. Schneeweiss, M. Schoemaker, B. Schöttker, P. Schürmann, L. Senter, Priyanka Sharma, M. Sherman, X. Shu, C. Singer, S. Smichkoska, P. Soucy, M. Southey, J. Spinelli, J. Stone, D. Stoppa-Lyonnet, A. Swerdlow, C. Szabo, R. Tamimi, W. Tapper, Jack A. Taylor, M. Teixeira, M. Terry, M. Thomassen, D. Thull, M. Tischkowitz, A. Toland, R. Tollenaar, I. Tomlinson, Diana Torres, M. Troester, Thérèse Truong, N. Tung, M. Untch, C. Vachon, A. V. D. van den Ouweland, L. E. van der Kolk, Elke M. van Veen, E. J. van Rensburg, A. Vega, B. Wappenschmidt, C. Weinberg, J. Weitzel, H. Wildiers, R. Winqvist, A. Wolk, Xiaohong R. Yang, D. Yannoukakos, W. Zheng, K. Zorn, M. Zuradelli, R. Milne, P. Kraft, J. Simard, P. Pharoah, K. Michailidou, A. Antoniou, M. Schmidt, G. Chenevix-Trench, D. Easton, M. García-Closas, N. Chatterjee   +272 more
semanticscholar   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

A Large-Scale Genome-Wide Association Study in U.S. Holstein Cattle

Frontiers in Genetics, 2019
Genome-wide association study (GWAS) is a powerful approach to identify genomic regions and genetic variants associated with phenotypes. However, only limited mutual confirmation from different studies is available.
Jicai Jiang, Li Ma, Dzianis Prakapenka, P. Vanraden, J. Cole, Y. Da   +5 more
semanticscholar   +1 more source