Results 131 to 140 of about 42,338,399 (265)

Genetic risk factors for postoperative atrial fibrillation-a nationwide genome-wide association study (GWAS). [PDF]

Front Cardiovasc Med, 2023
Christensen MA, Bonde A, Sillesen M.
europepmc   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

A Pilot Randomized Study of NAT2 and YEATS4 Pharmacogenetic Return of Results in Adults with Hypertension and African Ancestry: The GUARDD‐US PGx Study

Clinical Pharmacology &Therapeutics, EarlyView.
Almost half of individuals with hypertension fail to achieve recommended blood pressure (BP) goals. Pharmacogenetic gene‐drug interactions may alter the efficacy of antihypertensive agents. We conducted a multicenter randomized controlled sub‐study of participants (N = 1874) with hypertension and self‐reported African ancestry to determine whether ...
Philip E. Empey, Nita A. Limdi, Dinushika Mohottige, Kady‐Ann Steen‐Burrell, Hrishikesh Chakraborty, Khoa A. Nguyen, Alexander S. Parker, Emily J. Cicali, Girish N. Nadkarni, Michelle A. Ramos, Sabrina Clermont, Erica N. Elwood, Mimsie Robinson, Nandini Shroff, Marc B. Rosenman, Ronald Huang, Larisa H. Cavallari, Julie A. Johnson, Paul R. Dexter, Todd C. Skaar, Kerri L. Cavanaugh, Christina M. Wyatt, Carol R. Horowitz, Rhonda M. Cooper‐DeHoff, Michael T. Eadon, on behalf of the IGNITE Pragmatic Trials Network   +25 more
wiley   +1 more source

Novel subtypes of metabolic associated steatotic liver disease linked to clinical outcomes: implications for precision medicine

Journal of Translational Medicine
Background & aims Although metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with high multimorbidity and mortality, existing classification systems and risk prediction models largely ignore the heterogeneity of MASLD ...
Chang Hong, Sheng-xing Liang, Ze-yang Li, Rui-ning Li, Hong-bo Zhu, Mingfei He, Hao Cui, Jing-zhe He, Yan Li, Jia-ren Wang, Xue-jing Zou, Wen-yuan Li, Lin Zeng, Li Liu, Lu-shan Xiao   +14 more
doaj   +1 more source

Comparing variants related to chronic diseases from genome-wide association study (GWAS) and the cancer genome atlas (TCGA). [PDF]

BMC Med Genomics, 2023
Jeon S, Park C, Kim J, Lee JH, Joe SY, Ko YK, Gim JA.   +6 more
europepmc   +1 more source

Integrative Genomic and Functional Investigation of the Multi‐Layered Genetic Architecture Between Anorexia Nervosa and Bone Loss

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Bone loss is a severe and often irreversible complication of anorexia nervosa (AN), yet the genetic mechanisms underlying this comorbidity remain underexplored. This study focuses on constructing a comprehensive genetic architecture between AN and estimated calcaneal bone mineral density (eBMD).
Tao Han, Yuke Wang, Yixiong Dang, Rong Xiang, Yan Zeng, Sheng He, Ye Ju, Zilan Chen, Ting Liu, Zihao Li, Yuqi Pang, Wanyi Tan, Jue Xu, Jingwen Jiang, Xia Jiang   +14 more
wiley   +1 more source

Sensitivity and Criterion Validity of ED100K Lifetime Eating Disorder Diagnoses: A Study Using a National Eating Disorder Quality Register

International Journal of Eating Disorders, EarlyView.
ABSTRACT Background Epidemiological and genomic studies of eating disorders (ED) require scalable approaches to case ascertainment. The self‐report ED100K questionnaire assesses lifetime ED diagnoses, has been translated into several languages, and has been used in large cohort studies, with data shared or planned for sharing through major repositories
Hunna J. Watson, Andreas Birgegård, Liv Hog, Lisa Dinkler, Emma Forsén Mantilla, Laura M. Thornton, Cynthia M. Bulik   +6 more
wiley   +1 more source

Genome-Wide Association Study (GWAS) of White Mold Resistance in Snap Bean. [PDF]

Genes (Basel), 2022
Arkwazee HA, Wallace LT, Hart JP, Griffiths PD, Myers JR.   +4 more
europepmc   +1 more source

Flowchart of this genome-wide association study (GWAS) of lattice degeneration of the retina, with 23,465 microsatellite (MS) markers.

, 2012
Flowchart of this genome-wide association study (GWAS) of lattice degeneration of the retina, with 23,465 microsatellite (MS) markers.
Akira Oka (157163), Hidetoshi Inoko (3038), Eiichi Okada (157147), Norihiko Ito (157107), Tomoko Shiota (157151), Yuta Hagihara (157156), Nobuhisa Mizuki (46911), Hidenao Ideta (157093), Masao Ota (157102), Junichi Yonemoto (157120), Akira Meguro (157086), Riyo Uemoto (157132), Masaki Takeuchi (157127), Ryuichi Ideta (157112), Tadayuki Nishide (157137), Tatsukata Kawagoe (157144), Yasuhito Iijima (157141)   +16 more
core   +1 more source

Causal correlations between inflammatory proteins and heart failure: A two‐sample Mendelian randomization analysis

ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.
Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu, Gui‐Qin Liu, Ya‐Ping Peng, Li‐Ling Zhang, Xian‐Jin Wang, Liang‐Chuan Chen, Yuan‐Xi Zheng, Xue‐Jun Xiang, Rui Qiao, Xian‐He Lin   +9 more
wiley   +1 more source