Results 111 to 120 of about 42,338,399 (265)
Association Between Genetic Ancestry and Multiple Sclerosis Severity
Annals of Neurology, EarlyView.Objective
The objective of this study was to determine whether genetic ancestry is associated with differences in the clinical course of multiple sclerosis (MS). Methods
Participants with MS living in the United Kingdom >18 years old were recruited from 2021 to 2025 and genotyped from saliva using a commercial array. Genetic ancestry was inferred using Benjamin M. Jacobs, Emily Tregaskis‐Daniels, Luisa Schalk, Jakub Nagrodski, ADAMS investigators, Michelle Peter, Rashmi Kaimal, Roxanne Murray, Sadid Hoque, Terri‐Louise Brown, Ghaniah Hassan‐Smith, Helen L. Ford, Bruno Gran, Karim L. Kreft, Cord Spilker, Outi Quinn, David Rog, Miriam Mattoscio, Elisa Visentin, Ramya Shamji, Grace Fawehinmi, Katila George, Maria Papachatzaki, Katharine Harding, Rod Middleton, Tarunya Arun, Waqar Rashid, Adil Harroud, Huw R. Morris, Eli Silber, Gavin Giovannoni, Alastair J. Noyce, Ruth Dobson +32 morewiley +1 more sourceGenetic Resilience and Resistance in Alzheimer's Disease Diagnosis and Pathology
Annals of Neurology, EarlyView.Objective
Some individuals avoid Alzheimer's disease (AD) pathology as they age, or retain cognition despite substantial pathology, suggesting mechanisms of resistance or resilience to neurodegeneration. Educational attainment (EA) is associated with reduced risk of cognitive decline, although the underlying mechanisms remain unclear.Ganna Leonenko, Kalliopi Mavromati, Lynne Hughes, Jonas S. Sundarakumar, Keeley Brookes, Kevin Morgan, Terry Quinn, Valentina Escott‐Price, the Alzheimer's Disease Neuroimaging Initiative +8 morewiley +1 more sourceIdentification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy [PDF]
, 2011 The aim of this study was to determine, through a genome-wide association study (GWAS), the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis (SSc).Kreuter, A, Riel, P.L.C.M. van, V. Fonollosa, Baere, E. de, Chee, MM, Herrick Ariane, Arnett FC, M. F. González Escribano, A. T. Lee, Voskuyl AE, Nelson JL, Ortego-Centeno, N., Martin Jose-Ezequiel, Vanthuyne M, Hesselstrand Roger, González-Escribano, María F, Houssiau, F., Hesselstrand, Roger,, B. Z. Alizadeh, Spanish Scleroderma Grp, Wigley, Frederick M., Riemekasten, Gabriella, B. A. Lie, Wigley Frederick M., Voskuyl Alexandre E., Shiels, P.G., Alizadeh, Behrooz Z., van Riel, Piet L. C. M., Varga, J., Hesselstrand, Roger, Gregersen Peter K., Arnett, F. C., Hummers J., Westhovens Rene, Vanthuyne, M., Teruel, M., Padyukov, Leonid, Jacob van Laar, Teruel M, van Laar J, Italiaander, A, Kreuter, Alexander, Airó, Paolo, Scorza, Raffaella, Coenen Marieke J. H., Hesselstrand, R, Ortego Centeno N, Hummers, J, J. E. Martin, Gourh, Pravitt, A. Italiaander, A. E. Voskuyl, Francisco J García-Hernández, Maureen D Mayes, Díaz-Gallo, L. M., Torsten Witte, Arnett, FC, M. Vanthuyne, Assassi, Shervin, Martin, Javier, Ortego-Centeno Norberto, Nelson, JL, A. M. Hoffmann Vold, Martin, J.E., Christopher P. Denton, Kreuter, A., Carreira, P., J Lee Nelson, Hummers, Laura K., Lee, A.T., Broen, Jasper C, Riel, P.L. van, Westhovens R, Radstake, T. R., Shiels, Paul G., Peter K. Gregersen, Alizadeh Behrooz Z., Vonk, M.C., Lorenzo Beretta, Agarwal S, Hunzelmann N, De Keyser, FilipUGent801000564576976124243025F423C6B4-F0ED-11E1-A9DE-61C894A0A6B4, Tan, F.K., de Keyser, F, Vanessa Smith, Ruben van 't Slot, Shervin Assassi, Rajan Madhok, Worthington J, Norberto Ortego-Centeno, J. Ying, Arnett, Frank C., van Riel, PL, J. van Laar, A. J. Schuerwegh, Alizadeh, B.Z., Hoffmann-Vold, A.M., F. Houssiau, de Keyser Filip, Martin, J-E., Palm, Øyvind, González-Gay, Miguel A., Herrick, A., Nordin, A, Ophoff, Roel A, Simeon, Carmen P, Agarwal, Sandeep, Piet L. C. M. van Riel, Nelson, J Lee, Monique Hinchcliff, R. van't Slot, Roel A Ophoff, Chee Meng May, González-Escribano, MF, Chee MM, Laar, Jacob M. van, Broen JC, Riel, Piet L.C.M. van, Roger Hesselstrand, Tan Filemon K., P. Gourh, Carmen P. Simeon, Keyser, F. de, Koeleman, BP, Beretta, Lorenzo, Javier Martin, Fonollosa V, Hoffmann-Vold, A. M., Wigley, Frederick M, Hoffmann-Vold, A-M., Olga Gorlova, Westhovens, R., Radstake, Timothy RDJ, Broen Jasper C., Chee, Meng May, Nelson, J. Lee, Gorlova Olga, Carmen P Simeon, De Baere, ElfrideGE31UZGent8010010929250000-0002-5609-6895F50FFF8E-F0ED-11E1-A9DE-61C894A0A6B4, Varga, John, Nordin A, Bobby P C Koeleman, Hummers Laura K., Chee, M.M., Raffaella Scorza, Sandeep Agarwal, Voskuyl, Alexandre E., Houssiau, Fredric, Claudio Lunardi, C. P. Denton, Benedicte A Lie, R. A. Ophoff, Denton, CP, Koeleman, Bobby P C, Teruel, M, Marie Vanthuyne, Palm O, María F. González-Escribano, Palm Øyvind, van't Slot, Ruben, Simeón, Carmen P., Espinosa Garriga, Gerard, Shiels, Paul G, F. K. Tan, Schuerwegh Annemie J., F. C. Arnett, Witte T, Tan FK, van Laar, J, Martin, JE, Denton, C., Anna-Maria Hoffmann-Vold, Nordin, A., Alizadeh, Behrooz Z, Houssiau F, Italiaander, A., Laar, J. van, Fonseca, C, Riemekasten G, Paolo Airo, Oyvind Palm, Vicente Fonollosa, Vanthuyne Marie, García-Hernández, Francisco José, Paloma García de la Peña, Fonollosa, Vicente, Gourh P, Fonseca Carmen, Lund University., F. de Keyser, Herrick, Ariane, Madhok, R., Scorza, R., Piet L C M van Riel, Fonseca, Carmen, Mayes, MD, Hinchcliff Monique, Carreira, P, Worthington, J., R. Scorza, Teruel, María, María F González-Escribano, Fredric Houssiau, Beretta, L., Paul G Shiels, Agarwal, S, Agarwal Sandeep, Madhok, R, Gregersen, PK, Christopher I. Amos, Ophoff, Roel A., van Riel PL, Martin, J., Frank C Arnett, Lunardi Claudio, Assassi, S, Lunardi, Claudio, Shiels, P., Ortego-Centeno, N, E. de Baere, Arnett, Frank C, T. R. Radstake, Annemie J. Schuerwegh, Hoffmann-Vold Anna-Maria, Hoffmann Vold AM, Westhovens, Rene, van Riel, P., Fonseca C, Arnett, F.C., Diaz-Gallo, L.M., Christopher I Amos, Hummers, LK, Padyukov, L, McCarthy, M.I., Witte, T., Riemekasten, G., Gregersen, Peter K, J. Lee Nelson, Coenen, Marieke JH, Lee AT, Ying Jun, R. Madhok, Riemekasten Gabriella, Fonollosa, V., Behrooz Z. Alizadeh, Amos CI, Assassi Shervin, Hoffmann-Vold, Anna Maria, Koeleman, Bobby PC, Gabriella Riemekasten, González-Escribano, María Francisca, P. K. Gegersen, Denton, Christopher P., Ariane Herrick, Jasper C Broen, van Riel Piet L. C. M., Nelson, J.L., B. Rueda, Alexander Kreuter, Bobby P. C. Koeleman, Vonk, Madelon C, Fonseca, C., Wigley, F. M., Hinchcliff M, Diaz-Gallo, Lina Marcela, Denton CP, Marieke J. H. Coenen, Assassi, S., Smith, VanessaGE35UZGent0019912577298020000091300000-0001-6271-7945F83FAD26-F0ED-11E1-A9DE-61C894A0A6B4, García-Hernández, F.J., Rueda, B., van 't Slot Ruben, Elfride de Baere, van 't Slot, R, Simeon Carmen P., González-Gay, MA, J. C. Broen, P. Airo, Miguel A. González-Gay, Lie Benedicte A., García de la Peña P, C. P. Simeon, van't Slot, R., Hinchcliff, M., Broen, J.C., Gregersen PK, Rueda B, García de la Peña, P., Øyvind Palm, Shiels PG, Hunzelmann, N., Amos, Christopher I., A. Kreuter, Witte, T.J.M. de, de Baere, E., P. García de la Peña, Ophoff, R.A., González-Escribano María F., Koeleman, B. P., van Laar Jacob, Timothy R. D. J. Radstake, Smith V, Schuerwegh, AJ, Radstake, Timothy R D J, van Laar, Jacob, Mayes, Maureen D, Schuerwegh, A. J., Lee, Annette T., Gorlova, O, González-Gay Miguel A., Amos, CI, Baere, Elfride De, Diaz Gallo LM, Peter K Gregersen, Mayes MD, R. Hesselstrand, Madelon C Vonk, Vanthuyne, Marie, Padyukov Leonid, Radstake, Timothy R. D. J., Hunzelmann Nicolas, de la Peña Paloma, García P., Amos Christopher I., García Hernández FJ, Denton, C.P., de Baere, E, Gregersen, Peter K., González-EscribanoMarí, María F., Pena, P.G. de la, Gourh Pravitt, Houssiau, Frédéric, García de la Peña Paloma, Mayes, Maureen D., Fonollosa, V, Gonzalez-Escribano, Maria F., Lie, BA, null null, Jasper C. Broen, V. Smith, Maureen D. Mayes, Madelon C. Vonk, Radstake TR, Herrick, A, García de la Peña, Paloma, John Varga, N. Ortego Centeno, Fonollosa Vicente, Vonk, MC, Nordin Annika, Carreira P, Hesselstrand, R., Carreira, Patricia E., Martin, Jose-Ezequiel, Koeleman, B.P., Smith, V., Annet Italiaander, Gorlova, O., Nicolas Hunzelmann, Lie, Benedicte A., M. C. Vonk, Diaz-Gallo, L., Hesselstrand R, M. J. Coenen, O. Palm, González Gay MA, Mayes Maureen D., Diaz-Gallo, Lina-Marcela, Behrooz Z Alizadeh, Madhok, Rajan, Lie, B.A., Simeon, CP, Hummers, Laura K, Herrick A, Laura K. Hummers, S. Assassi, Slot, R. van 't, J. L. Nelson, Alizadeh BZ, Hummers, J., Diaz-Gallo, LM, Hunzelmann, N, Gourh, P, Shiels, PG, Pravitt Gourh, Frank C. Arnett, Smith Vanessa, Frederick M Wigley, Annette T. Lee, Radstake, T., Agarwal, Sandeep K., Kreuter A, Coenen, MJ, P. L. van Riel, de Baere Elfride, González-Gay, M.A., Voskuyl, AE, Wigley, F.M., Westhovens, R, Meng May Chee, Scorza R, Lie, Benedicte A, Arnett Frank C., Vonk MC, Beretta, L, Hummers, L. K., Mayes, M.D., Padyukov L, Witte, Torsten, Airo, P, Carreira, Patricia, Broen, JC, Denton Christopher P., Coenen, M., Schuerwegh AJ, Ying, J, Witte, T, T. Witte, Simeon CP, Radstake Timothy R. D. J., Alexandre E Voskuyl, P. G. Shiels, Schuerwegh, Annemie J, Italiaander, Annet, Shiels Paul G., Lee, AT, Jane Worthington, Teruel Maria, Hummers, L.K., Broen, J.C.A., Madhok R, García-Hernández, Francisco J., Martín, J. E., Vonk Madelon C., Maria Teruel, Varga, J, Lunardi, C, Koeleman BP, Assassi S, L. M. Diaz Gallo, García-Hernández Francisco J., Wigley, FM, Marieke J H Coenen, C. Lunardi, J. Martin, Madhok Rajan, Martin, Jose Ezequiel, Palm, Ø., Benedicte A. Lie, van Riel, Piet L C M, A. Herrick, Francisco J. García-Hernández, Schuerwegh, A.J., Witte Torsten, Nelson J. Lee, Ophoff Roel A., Christopher P Denton, De Baere, Elfride, M. Hinchcliff, Gorlova, Olga, M. A. González Gay, Voskuyl, A.E., Airo, P., Worthington, Jane, Coenen, Marieke J. H., Ying J, Palm, Oyvind, Tan, FK, Amos, Christopher I, González-Escribano, M.F., Voskuyl, Alexandre E, González-Gay, Miguel A, Alexandre E. Voskuyl, Gourh, P., Blanca Rueda, C. I. Amos, Varga John, Airo Paolo, Lee, Annette T, Tan, F., Broen, Jasper C., Ying, J., Coenen, Marieke J H, Lunardi, C., Alizadeh, BZ, Simeon, C.P., van Riel, Piet LCM, Fonollosa Pla, Vicent, Italiaander Annet, Coenen, M.J.H., Timothy R D J Radstake, González Escribano MF, Beretta L, F. M. Wigley, van 't Slot R, van 't Slot, Rubén, Carreira Patricia, Lie BA, Italiaander A, Annemie J Schuerwegh, M. Teruel, Palm, O, Tan, Filemon K., Hinchcliff, M, Kreuter Alexander, Smith, V, Filemon K Tan, Varga J, Gregersen, P.K., Leonid Padyukov, Annika Nordin, Houssiau Fredric, Radstake, TR, Rueda Blanca, García de la Peña, P, P. Carreira, Nelson, J. L., Ying, Jun, Jun Ying, Laura K Hummers, Palm, O., Martin, J, Smith, Vanessa, Carmen Fonseca, M. D. Mayes, Ophoff, RA, Filip de Keyser, Patricia Carreira, Hinchcliff, Monique, Miguel A González-Gay, Coenen MJ, Coenen, M. J., Ortego-Centeno, Norberto, Martin J., van 't Slot, R., Koeleman Bobby P. C., Spanish Scleroderma Study Group (SSSG), Radstake, T.R.D.J., Rene Westhovens, Airo P, Worthington, J, N. Hunzelmann, A. Nordin, L. K. Hummers, S. Agarwal, de Baere E, L. Padyukov, Ophoff RA, Riemekasten, G, García-Hernández, FJ, De Keyser, Filip, O. Gorlova, M. M. Chee, Diaz-Gallo Lina-Marcela, Lee Annette T., G. Riemekasten, de Keyser, F., Rueda, Blanca, Martin JE, Ophoff, R. A., Lie, B. A., J. Worthington, Koeleman, Bobby P. C., Vonk, Madelon C., Lina-Marcela Diaz-Gallo, Hunzelmann, Nicolas, Gorlova O, García-Hernández, Francisco J, Filemon K. Tan, Nordin, Annika, Paul G. Shiels, C. Fonseca, Schuerwegh, Annemie J., Jose-Ezequiel Martin, Beretta Lorenzo, de Keyser F, Denton, Christopher P, Simeón Aznar, Carmen Pilar, Frederick M. Wigley, Vanthuyne, M, Agarwal, S., Martin Javier, Scorza Raffaella, Houssiau, F, Hoffmann-Vold, AM, J. Varga, Scorza, R, B. P. Koeleman, Annette T Lee, Hoffmann-Vold, Anna-Maria, van Laar, J., L. Beretta, Koeleman, B.P.C., Padyukov, L., Hummers LK, Wigley FM, F. J. García Hernández, Rueda, B, Worthington Jane, Spanish Scleroderma Group, Alizadeh, B. Z., R. Westhovens, J. Hummers, Amos, C.I., Tan, Filemon K, Roel A. Ophoff, Lee, A. T., González-Gay Mantecón, Miguel Ángel, González-Gay, M. A., Amos, C. I., Riel, Piet L. C. M van, Martin, J-E, Tan, F. K., Chee, M. M., Diaz-Gallo, L-M, Mayes, M. D., Gregersen, P. K., Agarwal, S. K., Koeleman, BPC, Denton, Christopher +618 morecore +1 more sourceGenetic Diversity, Adaptation, Wild Introgression, and Coat Color Mutation of Golden Yak
Animal Research and One Health, EarlyView.Genetic diversity, adaptation, wild introgression, and coat color mutation of golden yak from two populations on the Qinghai‐Xizang Plateau. ABSTRACT
The golden yak lives on the Qinghai‐Xizang Plateau with a golden coat and adapts to high altitudes and strong ultraviolet environment. The golden coat is a prominent phenotype in many domesticated species,Huixuan Yan, Jialei Chen, Chuzhao Lei, Fengwei Zhang, Shunzhong He, Weiru Song, Hongyan Ma, Shuling Li, Guomei Li, Laba Yongcuo, Jianlin Han, Johannes A. Lenstra, Qiang Zhang, Rende Song, Basang Wangdui, Ningbo Chen +15 morewiley +1 more sourceA genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation. [PDF]
, 2013 BACKGROUND: Genome-wide association studies (GWAS) have identified several loci associated with schizophrenia and/or bipolar disorder. We performed a GWAS of psychosis as a broad syndrome rather than within specific diagnostic categories.Kahn, Rene S., Walshe, Muriel, Pearson, Richard, Van Os, J, Crespo Facorro, B, Sawcer, SJ, Palmer, Colin N.A., Markus, Hugh S, Toulopoulou, Timothea, Chandler, D, Myin-Germeys, Inez, Tashakkori Ghanbaria, A, Rautanen, A, Iyegbe, Conrad, Gray, E, Lewis, Cathryn M; id_orcid, Crespo-Facorro, B, Deloukas, P, Paunio, Tiina, Sawcer, Stephen J, Tashakkori-Ghanbaria, A, Peltonen, L, Palmer, Colin N. A., Kravariti, Eugenia, Edkins, Sarah, Di Forti, Marta, Arranz, Maria J., Hall, J, Dazzan, Paola, Palmer, CN, Pearson, R, Lewis, CM, Pariante, Carmine M, Su, Zhan, Collier, David A, McDonald, Colm, Corvin, A, Dazzan, Paola; id_orcid, Tashakkori-Ghanbaria, Avazeh, de Haan, L, Palmer, Colin NA, Donnelly, P, Bruggeman, Richard, Dazzan, P, Wood, Nicholas W., Potter, Simon C., Hunt, S, Iyegbe, C, Kalaydjieva, L, Bellenguez, Céline, Pariante, Carmine M., Bakker, S, Kahn, RS, Linszen, DH, Bramon, E, Pariante, CM, Murray, RM, Lins-Zen, Don H., Blackwell, Jenefer M., Pirinen, Matti, Collier, DA, Sauer, H, Duncanson, A, Trembath, Richard C, Weisbrod, M, Psychiatric Genomics Consortium, ., Bumpstead, Suzannah J., Van Os, Jim, Powell, John, Lin, Kuang, Trembath, RC, Linszen, Don H, ?, ?, Crespo-Facorro, Benedicto, Vukcevic, D, Ophoff, Roel A, Langford, C, Bakker, Steven, Jankowski, Janusz AZ, Peltonen, Leena, Jankowski, Janusz A. Z., Sawcer, Stephen J., Wiersma, Durk, Sauer, Heinrich, Shaikh, Madiha, Spencer, Chris CA, de Haan, Lieuwe, Strange, Amy, Paunio, T, Spencer, Chris C.A., Langford, Cordelia, Wood, NW, McIntosh, A, Ripke, Stephan, Freeman, Colin, Bender, Stephan, Hunt, Sarah, Blackwell, Jenefer M, Jankowski, JA, Lawrie, Stephen, Markus, HS, Linszen, Don H., Spencer, Chris C. A., Cahn, Wiepke, Tosato, S, Gray, Emma, Psychiatric Genomics Consortium, Lin, K, Brown, MA, Dronov, Serge, Jankowski, Janusz A.Z., Myin-Germeys, I, McIntosh, Andrew; id_orcid, Bender, S, Pariante, Carmine M; id_orcid, Dragović, Milan, Kravariti, Eugenia; id_orcid, Lewis, Cathryn M, Mathew, CG, Donnelly, Peter, Mathew, Christopher G, Edkins, S, Walshe, M, Tosato, Sarah, Picchioni, Marco, Hall, Jeremy, Di Forti, M, Trembath, Richard C., Psychosis Endophenotypes International Consortium, Potter, SC, Arranz, MJ, Wood, Nicholas W, Psychosis Endophenotypes International Consortium, ., Pirinen, M, Wiersma, D, Giegling, I, Jablensky, A, Potter, Simon C, Powell, J, Lewis, Cathryn M., Vukcevic, Damjan, Blackwell, JM, McIntosh, Andrew, Whalley, H, Ophoff, Roel A., Weisbrod, Matthias, Myin Germeys, I, Su, Z, Dronov, S, Casas, Juan P, Cahn, W, Plomin, R, Brown, Matthew A, Casas, JP, Mata, Ignacio, Mathew, Christopher G., Rujescu, Dan, Rautanen, Anna, Mathew, Christopher G; id_orcid, Bramon, Elvira, Plomin, Robert, Ophoff, RA, Toulopoulou, T, Freeman, C, Sussmann, J, Murray, Robin M., Jablensky, Assen, Sussmann, Jessika, Arranz, Maria J, Giegling, Ina, Bruggeman, R, Band, Gavin, Strange, A, Barroso, I, Brown, Matthew A., Picchioni, M, McDonald, C, Collier, David A., Casas, Juan P., Deloukas, Panos, Rujescu, D, Lawrie, S, Whalley, Heather, Psychiatric Genomics Consortium (Ripke, S, Barroso, Ines, Shaikh, M, Kravariti, E, Duncanson, Audrey, Spencer, CC, Powell, John; id_orcid, Markus, Hugh S., Mata, I, Suvisaari, Jaana, Band, G, Bumpstead, SJ, Ripke, S, Wellcome Trust Case-Control Consortium 2, Murray, Robin M, Kalaydjieva, Luba, Bellenguez, C, Chandler, David, Dragović, M, Suvisaari, J, Kahn, René S, Wellcome Trust Case-Control Consortium 2, ., Corvin, Aiden, Bumpstead, Suzannah J, Wellcome Trust Case-Control Consortium +207 morecore +1 more sourceGenome-wide association study of sucrose content and stem diameter in sugarcane (Saccharum spp.)
Journal of Integrative AgricultureIncreasing the sucrose content of sugarcane, a major sugar crop, is a key breeding objective. However, the complex genetic background of sugarcane affects development of sugarcane hybrids.Fenggang Zan, Zhuandi Wu, Chengcai Xia, Long Zhao, Qi Liu, Zihao Wang, Yanjie Lu, Meiling Zou, Yong Zhao, Peifang Zhao, Xuan Luo, Jiayong Liu, Zhiqiang Xia +12 moredoaj +1 more sourceMicroRNA‐Seq Analysis Reveals a Critical Role for miR‐222 in Bovine Intramuscular Adipogenesis via the DDIT4/mTORC1 Axis
Animal Research and One Health, EarlyView.Schematic diagram illustrating how miR‐222 promotes bovine intramuscular adipogenesis by targeting DDIT4 to activate the mTORC1 signaling pathway. ABSTRACT
Intramuscular fat (IMF) is a key determinant of beef quality, particularly with respect to tenderness, flavor, and juiciness.Jianbing Tan, Liang Qiu, Zhenghai Zhou, Zhipeng Zhang, Nanfei Wang, Jiangang Hao, Linsen Zan, Wucai Yang +7 morewiley +1 more source
