Results 101 to 110 of about 115,835 (257)

Genome-Wide Association Study Reveals Genetic Loci, Candidate Genes and Favorable Haplotypes for Important Agronomic Traits in Auricularia cornea

Journal of Fungi
Auricularia cornea is rich in nutrients and bioactive compounds, and with the continuous expansion of its industrial cultivation, elucidating the genetic basis of key agronomic traits is essential for marker-assisted breeding and cultivar improvement. In
Xu Sun, Lixin Lu, Fangjie Yao, Ming Fang, Xiaoxu Ma, Yuling Cui, Jian Sun, Xianqi Shan, Wei Liu   +8 more
doaj   +1 more source

A genome-wide association study (GWAS) of the personality constructs in CPAI-2 in Taiwanese Hakka populations. [PDF]

PLoS One, 2023
Kao PY, Chen MH, Chang WA, Pan ML, Shu WD, Jong YJ, Huang HD, Wang CY, Chu HY, Pan CT, Liu YL, Lin YS.   +11 more
europepmc   +1 more source

Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure

Clinical Pharmacology &Therapeutics, EarlyView.
This study investigated genetic determinants of the pharmacokinetics of the CYP2C8 index drugs repaglinide and gemfibrozil, and their interaction in healthy participants. Sequencing data from a study with montelukast revealed a novel functional CYP2C8 allele (rs2071426, CYP2C8*19), predicted to create an intronic splice donor site.
Anssi J. H. Mykkänen, Päivi Hirvensalo, Kathrin Klein, Dorota Kaminska, Markus Grube, Tuija Tapaninen, Johanna I. Kiiski, Mikko Neuvonen, Ville T. Männistö, Jussi Pihlajamäki, Mladen Tzvetkov, Matthias Schwab, Aleksi Tornio, Janne T. Backman, Mikko Niemi   +14 more
wiley   +1 more source

Disentangling Sex Differences in Sulfonylurea Drug Response With Genome‐Wide Association Studies in Individuals With Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
A sex‐stratified genome‐wide association study of sulfonylurea response identified sex‐specific genetic loci associated with HbA1c reduction in individuals with type 2 diabetes. Replication and functional validation supported a male‐specific association at the TMEM64/NECAB1 locus, highlighting the potential of sex‐informed pharmacogenomics to advance ...
Joseph H. Breeyear, John S. House, Mark Kvale, Stella Nam, Farida S. Akhtari, Hetal S. Shah, Monique M. Hedderson, Kathleen M. Giacomini, Josyf C. Mychaleckyj, Alessandro Doria, Michael J. Wagner, Josephine H. Li, Sook Wah Yee, John B. Buse, Richard P. Woychik, Daniel M. Rotroff, Alison A. Motsinger‐Reif   +16 more
wiley   +1 more source

Genome-wide association study (GWAS) of circulating vitamin D outcomes among individuals of African ancestry. [PDF]

Am J Clin Nutr, 2023
Parlato LA, Welch R, Ong IM, Long J, Cai Q, Steinwandel MD, Blot WJ, Zheng W, Warren Andersen S.   +8 more
europepmc   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source

Genome-wide association study (GWAS) of leaf wax components of apple. [PDF]

Stress Biol, 2021
Cao F, Li Z, Jiang L, Liu C, Qian Q, Yang F, Ma F, Guan Q.   +7 more
europepmc   +1 more source

Genome-Wide Association Studies (GWAS) [PDF]

, 2019
openaire   +1 more source

Causal Association Between Lifestyle Behavior and Potential Risk Factors With Blepharoptosis

Eye &ENT Research, EarlyView.
ABSTRACT Background Blepharoptosis is among the most common disorders of eyelid malposition that may influence appearance and damage visual function, and both of these can have negative effects on the quality of life. Various types of blepharoptosis have been reported, including neurogenic, traumatic, congenital, mechanical, psychogenic, and myogenic ...
Shiqi Hui, Zhijia Hou, Dong‐mei Li
wiley   +1 more source

Impact of cytosine and piperine on colorectal cancer progression based on Mendelian randomization and functional validation

Discover Oncology
Background Metabolic dysregulation is increasingly implicated in tumorigenesis, but the metabolic profile of colorectal cancer (CRC) has not been fully elucidated.
Liwei Su, Zhengqi Peng, Arzoo Prasai, Pengkhun Nov, Yujing Tan, Mengchuan Wang   +5 more
doaj   +1 more source