Results 81 to 90 of about 42,338,399 (265)

Genome-wide association and functional follow-up reveals new loci for kidney function [PDF]

, 2012
Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new
Döring, Angela, Atkinson, Elizabeth J, Gary C Curhan, Wichmann HE, Thun, G.-A., Trompet, S., Heid, I. M., Goessling Wolfram, Kroemer H.K., Boerwinkle, E., Kähönen M., Wilson J.F., Franke A., Biffar Reiner, Palmer, C., Zemunik T, Toshiko Tanaka, Rettig Rainer, Rao, Madhumathi, Toniolo, D. (Daniela), Smith, AV, Liu C.-T., Harshal Deshmukh, Curhan, G. C., Foster, Meredith C, Taliun, D, Heid Iris M., Gao, XY, Ridker P., Glazer, N., Fox Caroline S., Liu, Ching-Ti, Struchalin, M.V. (Maksim), Trompet, S. (Stella), O´Connell, J.R., Böger C.A., Chu, A.Y., de Andrade M, Smith AV, Fuchsberger Christian, Krämer, B.K., Hwang, S. J., Atkinson, Elizabeth J., Igl, W., Harris, T.B. (Tamara), Jingzhong Ding, Turner ST, Vollenweider Peter, Voelker, Uwe, Adrienne Tin (160761), Toniolo, D, J. Wouter Jukema (127361), Johnson, A.D. (Andrew), Vincent Chouraki, Uitterlinden A.G., Gorski, M. (Mathias), Adam M, Andrews JS, Rivadeneira, F, Turner, S. T., Wheeler, H.E., Gyllensten, Ulf,, Turner, ST, Rao M, Henry Völzke (64286), Meredith C. Foster (165430), Tin, A., Florian Kronenberg (87557), Andrews, J.S. (Jeanette), Nikopensius, Tiit, Shuldiner AR, Rudan, I. (Igor), Jie Jin Wang (103779), Borecki, I, Freedman, BI, Portas L, Ulivi, S, Nauck, Matthias, et al., Rao Madhumathi, Smith, A.V. (Albert Vernon), Stumvoll Michael, Ketkar S, Imboden, Medea, Peter P. Pramstaller (150111), Trompet S., Gudny Eiriksdottir (8872), Doney, A., Hastie N., Karlhans Endlich, Illig T, Vitart, Veronique, Homuth, G. (Georg), Rao M., Johansson, Åsa,, Kolcic, I. (Ivana), O'Seaghdha, Conall, Kähönen, M., Ketkar, S, Cavalieri, M., Probst-Hensch, NM, Wright, A.F., Gao, X., Deshmukh H, Minelli, Cosetta, Gasparini P., Chu, AY, Ciullo, M., Conall M O'Seaghdha, Ulf Gyllensten, Li, M. (Man), Probst-Hensch, Nicole M., Paulweber, B, Wild, S.H. (Sarah), Robino, A, Atkinson EJ, Rettig R, Buckley, B.M., Dehghan A, Johansson, Å, Illig, T., Yang, Q., Franke, Andre, Wang, J.J. (Jie Jin), Adam M., Biffar R., Colhoun, H., Cornelis MC, Curhan GC, Kolcic Ivana, Thun, G.A., Borecki I, Ding, JZ (Jing Zhong), Tönjes A., Tönjes, A. (Anke), Ding Jingzhong, Iris M Heid, Völzke, H, Kim, SK, Lohman K, Kroemer, H. K., Thun, G. A., Liu, CT, Hofman A, Köttgen, Anna, Qiong Yang, Ferrucci Luigi, Adam Martin, Boban, M., Wright, AF, Aulchenko, Y.S., Mariza de Andrade (31845), Holliday, E.G., Zaboli, G, Ding, Jingzhong, Albert V Smith, Bernhard Paulweber, Probst-Hensch Nicole M., Florian Ernst, Nick Hastie, Luigi Ferrucci (150038), Endlich Karlhans, Stumvoll, M. (Michael), Nicole M Probst-Hensch, Polasek, Ozren, Matthias Nauck, Stuart K. Kim (112150), De Andrade, M, Andrews, Jeanette S., van Duijn, Cornelia M., Anna Köttgen, Ciullo, M, Kao, WHL, Karlhans Endlich (112716), Garnaas Maija, Trompet, Stella, Palmer, Colin; id_orcid, Murgia, Federico, Struchalin, M., Gibson, G., Thor Aspelund, Ozren Polasek (3965693), Chen, M.H., Ching-Ti Liu, Pramstaller, PP, Hwang Shih-Jen, Rettig R., Vollenweider, P, Wilmar Igl, Oostra Ben A., Kovacs P, Afshin Parsa (175121), Coresh, J., Kutalik, Z. (Zoltán), Esko, T. (Tõnu), Fuchsberger, C., Pirastu, M, Cornelis, Marilyn C, Pistis, G, Chouraki, V. (Vincent), Tanaka, T, Haun M., Struchalin Maksim, Thun GA, Mägi, R., Mitchell, Braxton D., Demirkan, A, Köttgen, A., Colhoun H, Deshmukh, H., Liu Y., Launer, L. J., Garnaas M., Heid, I.M. (Iris), Andrade, M. de, Franke, A., Biffar, R., Chasman, D.I. (Daniel), Gyllensten Ulf, Campbell, Harry, Teumer, A. (Alexander), Goessling, W, Man Li (81239), Colin Palmer (165015), Liu, C. T., Ellinghaus, D., Wichmann H.-E., Wang JJ, Feitosa, M.F. (Mary Furlan), Jacqueline C. M. Witteman (175109), Bochud, M., Andrews, J. S., Bergmann, S, Tin Adrienne, O'Seaghdha C.M., Parsa, A., Goessling W, Döring Angela, Li G., Uitterlinden Andre G., Thun G.-A., Hu, Frank B., Portas, Laura, Gorski M, Chasman, DI, Georg Homuth (110202), Kardia, S.L.R., Kronenberg F, Holliday, E. G., Pistis, G. (Giorgio), Fox, C.S., Vilmundur Gudnason, Mitchell, Paul, Freedman Barry I., Doering, Angela, Ruggiero D., Wild S.H., Li, M., Ivana Kolcic, Chu, Audrey Yu-lei, Wilson, J.F., Imboden M, Goessling, W. (Wolfram), Raitakari, O., van Duijn CM, Wolfgang Koenig, Marie Metzger (156894), Chen M.-H., Launer Lenore J., Li M., Ding, J.Z., Schmidt, H., Mladen Boban, Ghazal Zaboli (174959), Ernst, F, Jacobs, Gunnar, Wichmann, HE, Isaacs, A., Kardia, Sharon L. R., Stracke, Sylvia, Trompet Stella, Stuart K Kim, Boban, Mladen, Koenig, W. (Wolfgang), Hwang, S.J., Wilson, James F; id_orcid, Nicole Glazer, Kim S.K., Feitosa M., Kovacs, P, Bergmann, S., Völker, U., Jukema J. Wouter, Rettig, R. (Rainer), Teumer, Alexander, Wright Alan F., Demirkan, A. (Ayşe), Ciullo Marina, Toshiko Tanaka (174638), Illig, T, Cavalieri M., Ming-Huei Chen, Bochud M., Aulchenko, Yurii S., Ute Nöthlings (140098), Toniolo Daniela, Nauck Matthias, Prokopenko, I, Giorgio Pistis, Böger CA, Struchalin, M, Schmidt, R. (Reinhold), Gian-Andri Thun, Kao WH, Hayward C, Colhoun Helen, Paul Mitchell (103717), Guo Li (174860), Cinzia Sala (74631), Siscovick D.S., Kardia, S.L., Gasparini, Paolo, Gudnason Vilmundur, Fox, Caroline, Giulianini F., Kovacs, Peter, Laura Portas (175069), Jacobs G, Parsa, A. (Afshin), Chen Ming-Huei, Reedik Mägi, Hayward, Caroline, Hofman, A. (Albert), Lehtimäki T, Viikari Jorma, Abbas Dehghan (174878), Albert Hofman, Igl, Wilmar, Daniel Taliun, Wild, S. H., Aspelund Thor, Ford, I., Nauck M., CARDIoGRAM Consortium, Kroemer, H.K., Hu Frank B., Heid I.M., Wheeler H.E., O'Seaghdha, Conall M, Coresh, J, Nick Hastie (175020), Tin, Adrienne, Mitchell, P, Schmidt, R., Helena Schmidt (174915), Aspelund, T, Deshmukh, Harshal, Elizabeth G Holliday, Wheeler HE, Oostra, B.A., Pirastu Mario, Stumvoll M, Turner, S.T., Völker U., Glazer N., Mitchell, P., Atkinson E.J., Chu A.Y., Paul Mitchell, Peter Kovacs (103720), Martin Adam (175082), Wilson, JF, Yang Q, Rossella Sorice, Alan R. Shuldiner (110828), Böger, Casten A, Tiit Nikopensius, Ernst Florian, Portas, L., Sorice, R, Taliun Daniel, Nikopensius T., Jukema J.W., Li, G., Metzger M., Cavalieri, M. (Margherita), Cinzia Sala, Zaboli G, Glazer Nicole, Pistis Giorgio, Kao, W. H. Linda, Wilson, J.F. (James), Murgia, F, Foster, M.C., Pattaro C., Wright A.F., Kardia, S.L.R. (Sharon), Andre Franke, Ellinghaus D, Braxton D Mitchell, Yurii S. Aulchenko (148330), Mitchell B.D., Peter Kovacs, Kaehoenen, Mika, Stracke S., Li, G (Guo), Rivadeneira Ramirez, F. (Fernando), Mario Pirastu (175088), Olden M, Ford, I. (Ian), Oostra B.A., Campbell, H. (Harry), Holliday EG, Wichmann, H.-E., Ciullo M, Lenore J. Launer (110269), Hu, F.B., Kao, W.H.L., Buckley, BM, WTCCC2, Gao, X, Thomas Illig (44906), Sala, C, Colhoun, Helen, Van Duijn, CM, Demirkan, A., Bochud, Murielle, Yang Q., Aspelund T, Eiriksdottir, G, Gasparini, P., Nikopensius Tiit, Wang, JJ, Uitterlinden, AG, Illig, T. (Thomas), Homuth G., Tamara B Harris, Deshmukh Harshal, Vitart Veronique, Madhumathi Rao, Chen MH, Haun, Margot, Hundertmark C., Carsten A Böger, Giulianini, F., Chu, Audrey Y, Aspelund, T. (Thor), Andrews Jeanette S., Madhumathi Rao (174925), Margherita Cavalieri (174919), Kronenberg F., Nauck, M., Cosetta Minelli, Campbell, Harry; id_orcid, Metzger Marie, Ferrucci, L. (Luigi), Sharon L R Kardia, Kolcic, I., Wheeler, HE, Kollerits, Barbara, Angela Döring (64291), de Andrade Mariza, Florian Ernst (174614), David Ellinghaus (87596), Liu CT, Ford, Ian, Conall M. O'Seaghdha (174855), Ford I., Colhoun H., Daniela Toniolo, Imboden M., Zemunik T., Shuldiner, A.R., Ingrid Borecki (175089), Kutalik Zoltan, Boerwinkle E., Paulweber Bernhard, Liu Y, Pattaro C, Wild Sarah H., Kovacs Peter, Province, M., Sorice R., Prokopenko, Inga, Hwang S.-J., Bergmann, Sven, Launer, Lenore J., Fox, C. S., Bergmann, S.M. (Sven), Wichmann, H. E., Giulianini Franco, Garnaas, M., Jacobs G., Imboden, M. (Medea), Franke Andre, Parsa A, Magi, Reedik, Liu, C.-T., Esko, T, David S. Siscovick (174822), Gierman Hinco J., David Ellinghaus, Brendan M. Buckley (175076), Buckley Brendan M., Lohman, K, Nikopensius, T, Aulchenko, Y. S., Boban, M, Maija Garnaas, Gunnar Jacobs (174977), Andre G. Uitterlinden (89938), Minelli C., Jukema, J.W., Schmidt, Helena, Ferrucci L., Luigi Ferrucci, Koenig, W, Stumvoll M., Probst-Hensch, N.M., Gyllensten U., Homuth, G., Mika Kähönen, H-Erich Wichmann, Meredith C Foster, Uitterlinden, A. G., Jacobs, Gunar, Andres Metspalu (61760), Sorice, Rossella, Fuchsberger, Christian, Goessling, Wolfram, Curhan Gary C., Coresh J, Haun M, Paolo Gasparini (139832), Laura Portas, Esko Tõnu, Rainer Rettig (112747), Endlich K., Freedman, B.I., Haun, M. (Margot), Polasek, O., Chu AY, Hinco J Gierman, Ayse Demirkan (174933), Endlich, Karlhans, Homuth, Georg, Harris, TB, Nöthlings Ute, Hundertmark, C., Zemunik, T. (Tatijana), Sorice, R., Franke, A. (Andre), O'Connell, J.R., Kollerits B, Jingzhong Ding (165392), Province Michael, Elizabeth J. Atkinson (174866), Li, Guo, Oostra, B.A. (Ben), Gao X, Kao W.H.L., Ruggiero Daniela, Parsa Afshin, Yongmei Liu, Antonietta Robino (149863), Vitart, V, Mitchell, B.D. (Braxton), Fuchsberger C, Raitakari O., Hayward, C, Pramstaller PP, Deshmukh H., Rossella Sorice (140754), Vilmundur Gudnason (8873), Borecki, I.B. (Ingrid), Gyllensten, U. (Ulf), Gorski, M, Eiriksdottir Gudny, Böger, CA, Audrey Y. Chu (174895), W. H. Linda Kao (160779), Helena Schmidt, Probst Hensch NM, Ding J., Igor Rudan, Wichmann, H. -Erich, Siscovick, D.S. (David), Paulweber, Bernhard, O'Seaghdha, C. M., Ferrucci, L., Foster Meredith C., Oostra, B. A., Palmer C., O'Seaghdha, C.M., Marie Metzger, Henry Völzke, Antonietta Robino, Esko T, Alex Doney (175054), Isaacs, A, Tönjes, A, Gudnason V., Lehtimäki, T, Helen Colhoun, Cornelis, Marilyn, Giulianini F, Thun Gian-Andri, Campbell, H, Claudia Hundertmark (174852), Hofman, Bert, Wright, A. F., Kutalik Z., Toniolo, D., Hwang SJ, Eiriksdottir G, Kolcic, I, Ferrucci, Luigi, Teumer A., Johnson A.D., Bernhard K Krämer, Olden, M., Olden, M, Hundertmark Claudia, Michael Stumvoll, Mägi R., Jorma Viikari, Witteman JC, Ulivi, Sheila, Kim, Stuart K., Heid, IM, Fuchsberger, C, Wichmann, H.-Erich, Heyo K Kroemer, Anke Tönjes, Krämer, Bernhard K., Tin A, Hundertmark, Claudia, Siscovick, DS, Struchalin, Maksim, Gao, X.Y., Kollerits, B. (Barbara), Holliday, EG, Gian-Andri Thun (142891), Sven Bergmann, Albert V. Smith (103644), Johansson Åsa, Stella Trompet, Murgia, F., Chen, M. H., Franco Giulianini, Lehtimaeki, Terho, Coresh, J. (Josef), Nothlings, Ute, Olden, M. (Matthias), Michael Province (175044), Demirkan Ayse, Wild, S.H., de Andrade, M., James F Wilson, Eiriksdottir, G., Eric Boerwinkle (36288), Federico Murgia (174898), Bernhard Paulweber (102633), Robino Antonietta, Johnson, AD, Alan F Wright, Metspalu A, Mitchell Paul, Catherine Helmer (175026), Wheeler, Heather E., Medea Imboden (110145), Gorski, M., Probst-Hensch, N. M., Caroline Hayward, Krämer B.K., Harris, Tamara B., Chouraki, Vincent, Trompet S, Giulianini, Franco, Harry Campbell, Ivana Kolcic (3212697), Frank B. Hu (127167), Launer, LJ (Lenore), Demirkan, Ayse, Schmidt, R, Uitterlinden, André; id_orcid, Schmidt, H, Ben A Oostra, Province, Michael, Veronique Vitart, Rivadeneira, F., Helmer, C, Hayward Caroline, Reiner Biffar (135695), Viikari, J, Rudan, Igor, Anna Köttgen (3111024), Mitchell Braxton D., Völzke H, Koenig Wolfgang, Martin Adam, Veronique Vitart (149854), Sylvia Stracke (175001), Turner S.T., Guo Li, Wilson, J. F., Dehghan, A. (Abbas), Smith, A. V., Völzke, H., Freedman, Barry I., Dehghan A., Igl W., Harris Tamara B., Köttgen A., Rettig, R., Chouraki V, Province, M, Ellinghaus David, Tin, A, Palmer, Colin, Jacobs Gunnar, Holliday, E.G. (Elizabeth), Rainer Rettig, Uitterlinden, A.G., Teumer A, Sarah H Wild, Pramstaller P.P., Biffar, R. (Reiner), Ford I, Wheeler, H. E., Nauck, M. (Matthias), Ridker, P.M. (Paul), Polasek Ozren, Adam, M., Kutalik, Z., Ferrucci L, Margherita Cavalieri, Oostra BA, Cornelis, M. (Marilyn), Alan F. Wright (150085), Kolcic, Ivana, Olden Matthias, Goessling, W., Tönjes A, Chouraki Vincent, Raitakari, O. (Olli), Hofman, A, Cavalieri, Margherita, Doney A, Hwang, S.-J., Angela Döring, Rudan, I, Curhan, G.C., Metspalu A., Launer, LJ, Vitart, V., Andrew D Johnson, Thun, GA, Thor Aspelund (103668), Döring, A, Isaacs A, Witteman, J.C.M. (Jacqueline), Christian Fuchsberger, Chen, M-H. (Ming-Huei), O'Connell, Jeffrey R., Hayward, Caroline; id_orcid, Uwe Völker, Vollenweider, P. (Peter), Pattaro, C. (Cristian), Polasek, O, Launer L.J., Michael Stumvoll (103716), Gierman, H.J., Palmer C, Johnson Andrew D., Chouraki, V., Krämer, BK, Ding, J., Caroline Hayward (149856), Paulweber B., Zaboli, Ghazal, Hastie Nick, Rivadeneira F., Mitchell P., Pirastu, Mario, Wang, Jie Jin, Gorski Mathias, Lehtimäki Terho, Nöthlings, U, Igor Rudan (150101), Borecki Ingrid, Shamika Ketkar, Curhan G.C., Illig T., Nicole Glazer (113632), Rao, M, Uitterlinden, Andre G., Rettig, Rainer, Schmidt R., Reinhold Schmidt, Ketkar, Shamika, Heid IM, Stella Trompet (174901), Zoltan Kutalik, Wheeler Heather E., Kronenberg, F. (Florian), Kutalik, Zoltan, Johansson, Asa, Johansson Å, Gasparini, P, Kronenberg, Florian, Elizabeth J Atkinson, Hofman, A., Sarah H. Wild (130180), Smith, Albert V, Schmidt, Reinhold, Palmer, C.N.A. (Colin), Vollenweider P., Doney Alex, Wilson JF, Minelli Cosetta, Ulivi, S. (Shelia), Prokopenko I, Gorski, Mathias, Struchalin M, Ridker, P, Hu FB, Kollerits, B, Heather E Wheeler, Toniolo D., Hofman Albert, Sala, Cinzia, Lehtimäki, Terho, Andres Metspalu, Abbas Dehghan, Kurt Lohman, O'Seaghdha, CM, Mladen Boban (149857), Kähönen Mika, Krämer Bernhard K., Gyllensten, U., Pramstaller, P.P. (Peter Paul), Qiong Yang (28822), Kähönen, M, O'Seaghdha, Conall M., Kurt Lohman (110218), Biffar, R, Thomas Illig, Ghazal Zaboli, Cornelis, Marilyn C., Launer, L.J., Homuth G, Chasman, Daniel I., Sala C, Mägi Reedik, Fernando Rivadeneira, Launer LJ, Zaboli G., de Andrade, Mariza, Shih-Jen Hwang, Jeanette S. Andrews (174941), Marina Ciullo (140763), Ulivi Sheila, Tamara B. Harris (110195), Atkinson Elizabeth J., Holliday, Elizabeth G., Daniel I Chasman, Yang, Qiong, Braxton D. Mitchell (110791), Kollerits Barbara, Gierman, Hinco J, Kovacs, P., Gierman HJ, Atkinson, E. J., Kardia Sharon L. R., Ciullo M., Isaacs, Aaron; id_orcid, Andrews J.S., Duijn, C.M. van, Lohman Kurt, Shih-Jen Hwang (79945), Harris TB, Zemunik Tatijana, Franke, A, Bergmann S, Paul Ridker, Ruggiero, D, Gierman, HJ, Gyllensten, Ulf, Helmer C, Nikopensius T, Franke A, Bochud M, Fuchsberger C., Dehghan, Abbas, Atkinson, EJ, Cristian Pattaro, Minelli C, Caroline S Fox, Schmidt Helena, Pramstaller, P. P., Taliun D., O'Connell, J. R., Demirkan A., van Duijn C.M., James F. Wilson (150146), Böger, C. A., Bergmann S., Palmer Colin, Johnson AD, Wright, A.F. (Alan), Stephen T. Turner (103474), Ching-Ti Liu (100170), Mary Feitosa (165417), Vitart, V. (Veronique), Pistis G., Ridker Paul, Margot Haun, H.-Erich Wichmann (72009), Ian Ford (30666), Harry Campbell (30339), Boban Mladen, Freedman BI, Pirastu M., Ulivi, S., Raitakari, Olli, Krämer BK, Rudan Igor, Rudan, I., Jukema, J. W., Ulivi S., Franco Giulianini (175060), Wilson, James F., Sala, C. (Cinzia), Chu, Audrey Y., Hinco J. Gierman (174862), Ulf Gyllensten (13773), Siscovick, D. S., Stracke, S., Doney, A, Metzger M, Li, Man, Wang, J. J., Illig, Thomas, Tõnu Esko (102379), Döring, A. (Angela), Hu, Frank, Völker Uwe, Mary Feitosa, Igl, W, Chen, M.-H., Koenig W, Adam, M, Vitart V, O'Connell, Jeffrey R, Ketkar S., Imboden Medea, Cosetta Minelli (38846), Johnson, Andrew D., Reiner Biffar, Völzke H., Matthias Olden, Mariza de Andrade, Aulchenko, Y.S. (Yurii), Hwang, Shih-Jen, Jukema JW, Portas L., Hwang, SJ, Polasek, O. (Ozren), Lohman, Kurt, Ford Ian, Wellcome Trust Case Control Consortium 2, Gyllensten, U, Vitart V., Harshal Deshmukh (174893), Freedman B.I., Caroline S. Fox (110474), Yang, Q. (Qiong Fang), Alexander Teumer (112757), Holliday, Elizabeth G, Kao W. H. Linda, Marilyn C. Cornelis (174871), Boger, C.A., Kroemer, H.K. (Heyo), Parsa, Afshin, Kovacs P., Tõnu Esko, Liu Ching-Ti, Dehghan Abbas, Buckley B.M., Jukema, J. Wouter, Haun, M, Anke Tönjes (103703), Johnson, A.D., Afshin Parsa, Ernst F., Vollenweider, P., Völker U, Jeffrey R. O'Connell (170220), Wilson James F.   +999 more
core   +1 more source

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

Genome-wide association study of behavioural and psychiatric features in human prion disease. [PDF]

, 2015
Prion diseases are rare neurodegenerative conditions causing highly variable clinical syndromes, which often include prominent neuropsychiatric symptoms.
Carswell, C, MacKay, A, Thompson, AG, Porter, MC, Rudge, P, Collinge, J, Lowe, J, Mead, S, Uphill, J, Lukic, A   +9 more
core  

Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array [PDF]

, 2009
The outcome of Genome-Wide Association Studies (GWAS) has challenged the field of blood pressure (BP) genetics as previous candidate genes have not been among the top loci in these scans.
Döring, Angela, Illig, T, Peeter Juhanson, Katrin Kepp, Juhanson, P., Juhanson, P, Samani, Nilesh, Philip Howard, Caulfield, Mark J., P. B. Munroe (7602386), Veldre, G, Farrall, Martin, Lichtner Peter, Dobson, RJ, Viigimaa, M., C. Gieger (7609259), Morris Brown, Putku Margus, Wichmann, H.-E., Illig, T., Siim Sõber, Gudrun Veldre, Shaw-Hawkins, Sue, Kelgo, Piret, Illig Thomas, R. J. Dobson (7602557), Samani, N, Samani Nilesh, Laan, Maris, HYPertens ESTonia Study, A. Dominiczak (7611551), Munroe, Patricia B., Kepp, K, John Connell, T. Illig (7609322), Samani, N., M. Putku (7602647), Viigimaa Margus, Farrall Martin, Brown, M, Peter Lichtner, Sober, S, A. Döring (7609562), Lichtner, Peter, P. Howard (7611350), Piret Kelgo, Juhanson Peeter, Dobson, Richard J.; id_orcid, Org, E, Farrall, M, Dobson, R.J., Meitinger, T, Veldre, Gudrun, E. Org (7602644), Kooperative Gesundheitsforschung in der Region Augsburg Study, Lichtner, P., H-Erich Wichmann, Martin Farrall, Kepp, Katrin, Gieger, Christian, HYPertension in ESTonia Study, Margus Putku, Newhouse, SJ, Onipinla Abiodun, Caulfield Mark J., Meitinger, T., M. Laan (7602659), Caulfield, MJ, Maris Laan, Eyheramendy, S., Onipinla, A., Newhouse, S.J., M. Viigimaa (7602620), Gieger, C, Dominiczak, A., Kelgo, P, Onipinla, A, Döring Angela, Newhouse, Stephen J.; id_orcid, Shaw-Hawkins Sue, Susana Eyheramendy, Munroe, PB, Klopp, Norman, Newhouse, Stephen J., Brown, Morris, Putku, Margus, M. Farrall (6522599), Wichmann, H.-Erich, Meitinger Thomas, S. Eyheramendy (7611197), Wichmann, Heinz-Erich, Putku, M, M. Brown (3020991), Gieger, C., Christian Gieger, Döring, A., Dobson, Richard J., Munroe, P.B., Juhanson, Peeter, Lichtner, P, Richard J Dobson, Org, E., H-E. Wichmann (7611602), Doering, Angela, Howard Philip, Kepp, K., Org, Elin, Kelgo Piret, Anna Dominiczak, Klopp, N., S. Shaw-Hawkins (7602380), Org Elin, Gieger Christian, Dominiczak Anna, Margus Viigimaa, Viigimaa, Margus, Newhouse Stephen J., K. Kepp (7611593), Sue Shaw-Hawkins, Stephen J Newhouse, Howard, P., Munroe Patricia B., Wichmann, H. Erich, P. Kelgo (7611596), Wichmann H.-Erich, Eyheramendy, S, Kooperative Gesundheitsforsch, Putku, M., M. J. Caulfield (7602383), Patricia B Munroe, Howard, P, Angela Döring, Eyheramendy, Susana, Nilesh Samani, Veldre Gudrun, Kepp Katrin, Sõber Siim, J. . Connell (7611608), Wichmann, HE, MRC British Genet Hypertens Study, Laan, M., Laan Maris, Elin Org, Connell, J, Illig, Thomas, Meitinger, Thomas, Doring, A, Viigimaa, M, Thomas Illig, N. Klopp (7611599), S. J. Newhouse (7602371), Connell John, S. Sõber (7602650), Shaw-Hawkins, S, Onipinla, Abiodun, Shaw-Hawkins, S., Dobson Richard J., Dominiczak, A, Klopp Norman, T. Meitinger (14191), Abiodun Onipinla, G. Veldre (7602656), Sõber, Siim, Thomas Meitinger, Eyheramendy Susana, P. Lichtner (7611605), A. Onipinla (7602377), Mark J Caulfield, Klopp, N, Caulfield, M.J., N. Samani (7611611), P. Juhanson (7602641), Dominiczak, Anna, Veldre, G., Connell, J., Connell, John, Norman Klopp, MRC British Genetics of Hypertension Study, Brown, M., Sõber, S., Howard, Philip, Brown Morris, Laan, M, Sõber, S;Org, E;Kepp, K;Juhanson, P;Eyheramendy, S;Gieger, C;Lichtner, P;Klopp, N;Veldre, G;Viigimaa, M;Döring, A;Putku, M;Kelgo, P;Shaw-Hawkins, S;Howard, P;Onipinla, A;Dobson, RJ;Newhouse, SJ;Brown, M;Dominiczak, A;Connell, J;Samani, N;Farrall, M;Caulfield, MJ;Munroe, PB;Illig, T;Wichmann, HE;Meitinger, T;Laan, M   +183 more
core   +1 more source

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

Advanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou, Keqing Wang, Junhong Chen, Haoyu Wang, Xinjiang Tan, Xuanlin Huang, Zhiyin Lin, Xun Xu, Xin Jin, Shaoqiao Zhang, Liang Xiao, Yuanqiang Zou, Tao Zhang, Xiaomin Liu   +13 more
wiley   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Hepatic Lipid Stress Drives Metabolic Dysfunction‐Associated Steatohepatitis Progression through FTO O‐GlcNAcylation‐Induced m6A Demethylation of HRAS

Advanced Science, EarlyView.
Lipid stress drives O‐GlcNAcylation of the m6A demethylase FTO at Ser195, enhancing its stability and demethylase activity. This modification removes m6A from HRAS mRNA, preventing its degradation and activating PI3K/AKT signaling to promote hepatic steatosis and inflammation.
Jia‐Xin Yin, Yan‐Lai Zhang, Qun Liu, Rui Liu, Hai‐Yang Yuan, Sui‐Dan Chen, Ming‐Hua Zheng, Kai Wang, Ni Tang, Ai‐Long Huang   +9 more
wiley   +1 more source

Genome-wide heterogeneity between T2D strata.

, 2022
Manhattan plot for heterogeneity p-values comparing T2D and non-T2D groups. Only one locus achieved genome-wide significance and the corresponding variants are colored in green.
Kaavya Paruchuri (13994019), Margaret Sunitha Selvaraj (13994016), Rachel Bernardo (13994025), Sara Haidermota (13994022), Stephen S. Rich (7634141), Pradeep Natarajan (819434), Gina M. Peloso (12036929)   +6 more
core   +1 more source

Maternal Hyperglycemia Disrupts Cerebral Cortex Development Through the Foxp1‐Dll1‐Notch Axis

Advanced Science, EarlyView.
Maternal hyperglycemia disrupts offspring cortical development through a Foxp1–Dll1–Notch signaling axis. In a PGDM mouse model, intrauterine hyperglycemia decreases cortical thickness and perturbs neuronal layering by downregulating Foxp1, which transcriptionally regulates the Notch ligand Dll1.
Longkai He, Ya Jin, Guosheng Liu, Hao Liu, Xinyi Zhu, Weipeng Xu, Wei Li, Meiyao He, Yao Shen, Bingxiao Li, Xuesong Yang, Xiaoyu Wang, Shasha Han   +12 more
wiley   +1 more source