Genome-wide association studies (GWAS) and their importance in asthma
Allergologia et Immunopathologia, 2015 Asthma is a complex disease determined by the interaction of different genes and environmental factors. The first genetic investigations in asthma were candidate gene association studies and linkage studies. In recent years research has focused on association studies that scan the entire genome without any prior conditioning hypothesis: the so-called ...
Garc?a-S?nchez, A. +7 more
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Multiparental mapping of plant height and flowering time QTL in partially isogenic sorghum families. [PDF]
, 2014 Sorghum varieties suitable for grain production at temperate latitudes show dwarfism and photoperiod insensitivity, both of which are controlled by a small number of loci with large effects.
Assaranurak, I +3 more
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GWAS and WGCNA Analysis Uncover Candidate Genes Associated with Oil Content in Soybean
PlantsSoybean vegetable oil is an important source of the human diet. However, the analysis of the genetic mechanism leading to changes in soybean oil content is still incomplete.
Xunchao Zhao +7 more
doaj +1 more source
GenEpi: gene-based epistasis discovery using machine learning. [PDF]
, 2020 BackgroundGenome-wide association studies (GWAS) provide a powerful means to identify associations between genetic variants and phenotypes. However, GWAS techniques for detecting epistasis, the interactions between genetic variants associated with ...
Alzheimer’s Disease Neuroimaging Initiative +9 more
core
Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances [PDF]
, 2013 Twin and family studies indicate that the timing of primary tooth eruption is highly heritable, with estimates typically exceeding 80%. To identify variants involved in primary tooth eruption we performed a population based genome-wide association study ...
Alexei I. Zhurov +84 more
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Genetic regulation of mouse liver metabolite levels. [PDF]
, 2014 We profiled and analyzed 283 metabolites representing eight major classes of molecules including Lipids, Carbohydrates, Amino Acids, Peptides, Xenobiotics, Vitamins and Cofactors, Energy Metabolism, and Nucleotides in mouse liver of 104 inbred and ...
Bennett, Brian J +11 more
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Novel ABCD1 and MTHFSD Variants in Taiwanese Bipolar Disorder: A Genetic Association Study
MedicinaBackground and Objectives: In recent years, bipolar disorder (BD), a multifaceted mood disorder marked by severe episodic mood fluctuations, has been shown to have an impact on disability-adjusted life years (DALYs).
Yi-Guang Wang +9 more
doaj +1 more source
Genetics of Tinnitus: Time to Biobank Phantom Sounds
Frontiers in Genetics, 2017 Tinnitus is a common phantom sensation resulting most often from sensory deprivation, and for which little knowledge on the molecular mechanisms exists.
Christopher R. Cederroth +6 more
doaj +1 more source
Methodological Issues in Multistage Genome-Wide Association Studies [PDF]
, 2009 Because of the high cost of commercial genotyping chip technologies, many investigations have used a two-stage design for genome-wide association studies, using part of the sample for an initial discovery of ``promising'' SNPs at a less stringent ...
Casey, Graham +5 more
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Novel genetic loci affecting facial shape variation in humans
eLife, 2019 The human face represents a combined set of highly heritable phenotypes, but knowledge on its genetic architecture remains limited, despite the relevance for various fields.
Ziyi Xiong +49 more
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