Results 71 to 80 of about 42,338,399 (265)

Transposable Element Dynamics Drive the Genomic Evolution and Phenotypic Diversification of Allotetraploid Common Carp

Advanced Science, EarlyView.
By integrating 516 whole‐genome resequencing datasets and 236 transcriptomes of allotetraploid common carp, this study establishes the first population‐scale atlas of transposable element (TE) variation in teleost species. TE bursts, relaxed purifying selection, and lineage‐specific loss of ancient insertions shape genome evolution and phenotypic ...
Shuimu Hu, Zhou Jiang, Lin Chen, Gowena Ling Yi Goh, Weijing Li, Qian He, Xintong Chen, Rui Li, Yuxuan Liu, Ning Li, Tao Zhou, Peng Xu   +11 more
wiley   +1 more source

Genome-wide association study (GWAS) datasets used in the study.

Genome-wide association study (GWAS) datasets used in the study.
Zhekang Liu (17941199), Xinwang Duan (4595974), Yijia Shao (4578811)   +2 more
core   +1 more source

Genome-wide associate study identifies five new schizophrenia loci [PDF]

, 2011
We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent ...
The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium
core   +1 more source

Multi‐Layer Transcriptomic Comparison Across Human, Pig, and Mouse Informs Tissue‐ and Trait‐Specific Animal Model Selection

Advanced Science, EarlyView.
We integrated RNA‐seq data from humans, pigs, and mice across 15 matched tissues based on 14 910 one‐to‐one orthologous genes. Cross‐species similarity was systematically evaluated across multiple regulatory layers, including global co‐expression conservation, co‐expression networks, tissue‐specific programs, and 3D genome architecture.
Jingwen Dou, Yong Liao, Xiong Shen, Xin Huang, Zhenshuang Tang, Yuwei Gou, Huajun Zhou, Jingya Xu, Hong Liu, Yue Wang, Keke Liang, Jia Liu, Xiao Zhang, Chenyao Li, Shangjian Wang, Liangliang Fu, Lilin Yin, Xinyun Li, Shuhong Zhao, Xiaolei Liu, Jingjin Li, Yuhua Fu   +21 more
wiley   +1 more source

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source

GWAS and WGCNA Analysis Uncover Candidate Genes Associated with Oil Content in Soybean

Plants
Soybean vegetable oil is an important source of the human diet. However, the analysis of the genetic mechanism leading to changes in soybean oil content is still incomplete.
Xunchao Zhao, Yan Zhang, Jie Wang, Xue Zhao, Yongguang Li, Weili Teng, Yingpeng Han, Yuhang Zhan   +7 more
doaj   +1 more source

Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. [PDF]

, 2010
We performed a genome-wide association study (GWAS) in 1705 Parkinson's disease (PD) UK patients and 5175 UK controls, the largest sample size so far for a PD GWAS.
R. A. Barker, Z. Su, Spencer, C.C.A., Pearson, Justin P., McCarthy, Mark I, Wellcome Trust Case Control Consortium 2, Craddock, Nicholas John, Markus, Hugh S, Viswanathan, Ananth C., L. Peltonen, Hardy, J., Donnelly, P., Casas, J.-P., V. Plagnol, CORVIN, AIDEN PETER, Langford, C., Sawcer, Stephen J, Jankowski, J., Palmer, Colin N. A., E. Bramon, Edkins, Sarah, M. I. McCarthy, Peltonen, L., null null, G. Band, Craddock, Nicholas, Hudson, Gavin, Gray, E., Su, Zhan, Evans, Jonathan, Viswanathan, A.C., A. C. Viswanathan, Morrison, Karen, Mathew, Christopher G.; id_orcid, Palmer, Colin NA, Spencer, C. C., Morrison, K.E.; id_orcid, Hunt, S., Palmer, C.N.A., Wood, Nicholas W., Brown, Martin A., H. Blackburn, A. Strange, D. Burn, J. Evans, Corvin, A., P. Donnelly, Chinnery, Patrick F., Palmer, C. N., A. J. Lees, Potter, Simon, Pirinen, Matti, Trembath, Richard C, Plagnol, V., Hardy, John, McCarthy, M. I., J. P. Pearson, Morris, H. R., C. Freeman, Edkins, S., Clarke, Carl E, Blackburn, Hannah, Morris, H.R., Clarke, Carl; id_orcid, Bhatia, Kailash, Gardner, M., S. Edkins, Viswanathan, A. C., Peltonen, Leena, Burn, D., R. C. Trembath, Sawcer, Stephen J., K. Bhatia, C. Langford, Spencer, Chris CA, Strange, Amy, C. C. A. Spencer, Bellenguez, C., J. Jankowski, Freeman, C., Brown, M. A., Spencer, Chris C.A., Bhatia, K., Langford, Cordelia, Barker, R. A., Freeman, Colin, Hunt, Sarah, Clarke, Carl E., C. E. Clarke, Lees, A. J., Spencer, Chris C. A., P. F. Chinnery, Gray, Emma, Chinnery, P. F., Morris, Huw R., H. R. Morris, Paisan-Ruiz, C., Clarke, C.E., McCarthy, Mark I., Blackburn, H., Wood, N.W., Gardner, Michelle, Plagnol, Vincent, S. Potter, A. Rautanen, Wood, N. W., Evans, J., Morrison, K. E., Morrison, Karen E., Donnelly, Peter, C. Paisan-Ruiz, Chinnery, P.F., Pirinen, M., Lees, A.J., A. Corvin, Mathew, Christopher G, Su, Z., Craddock, N., Brown, Martin A, Morris, Huw Rees, Trembath, Richard C., Wood, Nicholas W, Viswanathan, Ananth C, Clarke, C. E., Burn, David, Barker, Roger A, Strange, A., Casas, J. P., C. G. Mathew, Williams, Nigel W, P. Deloukas, N. W. Williams, C. Bellenguez, UK Parkinson's Disease Consortium, Deloukas, P., Mathew, C. G., G. Hudson, Plomin, R., Spencer, Chris C A, N. W. Wood, S. Hunt, Morris, Huw R, Casas, Juan-Pablo, Barker, Roger A., Barker, Roger, Brown, Matthew A, Barker, R.A., Rautanen, Anna, Bramon, Elvira, Plomin, Robert, Jankowski, Janusz, Band, G., McCarthy, M.I., M. A. Brown, Brown, M. A, Sawcer, S.J., J. M. Blackwell, H. S. Markus, M. Gardner, Lees, Andrew J, Band, Gavin, Brown, Matthew A., Markus, H.S., Paisan-Ruiz, Coro, Rautanen, A., Williams, Nigel W., Williams, N.W., Pearson, Justin P, C. N. A. Palmer, Blackwell, J. M., Deloukas, Panos, Bellenguez, Celine, Williams, N. W., Morrison, K.E., S. J. Sawcer, Brown, M.A., Bramon, E., Trembath, R. C., Blackwell, Jennie M, Chinnery, Patrick F, Blackwell, Jennie M., Spencer, C. C. A., Markus, Hugh S., N. Craddock, Morrison, Karen E, Lees, Andrew J., Palmer, Colin N A; id_orcid, Blackwell, J.M., K. E. Morrison, Hudson, G., E. Gray, Potter, S., Palmer, C. N. A., Mathew, C.G., J.-P. Casas, J. Hardy, Williams, Nigel Melville, Pearson, J.P., R. Plomin, Pearson, J. P., Corvin, Aiden, Sawcer, S. J., M. Pirinen, Trembath, R.C., Markus, H. S.   +204 more
core   +2 more sources

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma

Nature Communications, 2018
Genetic loci linked to susceptibility for the common skin cancer cutaneous squamous cell carcinoma (cSCC) have been identified by genome wide association studies (GWAS).
Nilah M. Ioannidis, Wei Wang, Nicholas A. Furlotte, David A. Hinds, 23andMe Research Team, Carlos D. Bustamante, Eric Jorgenson, Maryam M. Asgari, Alice S. Whittemore   +8 more
doaj   +1 more source

Genetics of Tinnitus: Time to Biobank Phantom Sounds

Frontiers in Genetics, 2017
Tinnitus is a common phantom sensation resulting most often from sensory deprivation, and for which little knowledge on the molecular mechanisms exists.
Christopher R. Cederroth, Anna K. Kähler, Patrick F. Sullivan, Patrick F. Sullivan, Patrick F. Sullivan, Jose A. Lopez-Escamez, Jose A. Lopez-Escamez   +6 more
doaj   +1 more source