Results 61 to 70 of about 191,340 (203)

Exploring the novel SNPs in neuroticism and birth weight based on GWAS datasets

BMC Medical Genomics, 2023
Objectives Epidemiological studies have confirmed that low birth weight (BW) is related to neuroticism and they may have a common genetic mechanism based on phenotypic correlation research.
Xiao-Ying Zhou, Rui-Ke Liu, Chun-Ping Zeng   +2 more
doaj   +1 more source

Principles for the post-GWAS functional characterisation of risk loci [PDF]

, 2010
Several challenges lie ahead in assigning functionality to susceptibility SNPs. For example, most effect sizes are small relative to effects seen in monogenic diseases, with per allele odds ratios usually ranging from 1.15 to 1.3.
Alvaro N. A. Monteiro, Angela Risch, Chris Carlson, Christoph Plass, Dave Duggan, Gerhard A. Coetzee, Graham Casey, Haris G. Vikis, Ian G. Mills, Jay W. Tichelaar, Mariella De Biasi, Matthew L. Freedman, Michael James, Ming You, Pengyuan Liu, Simon A. Gayther   +15 more
core   +3 more sources

Genome-Wide Association and Transcriptome-Wide Association Studies Identify Novel Susceptibility Genes Contributing to Colorectal Cancer

Journal of Immunology Research, 2022
Background. Colorectal cancer (CRC) is among the most common cancers diagnosed worldwide. Although genome-wide association studies have effectively identified the genetic basis of CRC, there is still unexplained variability in genetic risk. Transcriptome-
Ruimin Yin, Binbin Song, Jingjing Wang, Chaodan Shao, Yufen Xu, HongGang Jiang   +5 more
doaj   +1 more source

Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies [PDF]

, 2019
Objective: Tourette’s syndrome is polygenic and highly heritable. Genome-wide association study (GWAS) approaches are useful for interrogating the genetic architecture and determinants of Tourette’s syndrome and other tic disorders. The authors conducted
Gilles de la Tourette GWAS Replication Initiative, Psychiatric Genomics Consortium Tourette Syndrome Working Group, Tourette Association of America International Consortium for Genetics, Tourette International Collaborative Genetics Study, Woods, Douglas W.   +4 more
core   +1 more source

A Common Variant in CLDN14 is Associated with Primary Biliary Cirrhosis and Bone Mineral Density. [PDF]

, 2016
Primary biliary cirrhosis (PBC), a chronic autoimmune liver disease, has been associated with increased incidence of osteoporosis. Intriguingly, two PBC susceptibility loci identified through genome-wide association studies are also involved in bone ...
Bian, Zhaolian, Chen, Haoyan, Gershwin, M Eric, Jiang, Xiang, Li, Enling, Li, Zhiqiang, Lian, Min, Liao, Wilson, Ma, Xiong, Miao, Qi, Seldin, Michael F, Shi, Yongyong, Tang, Ruqi, Wang, Qixia, Wang, Zhaoyue, Wei, Yiran, Yang, Fan, Yang, Yue, Zhang, Haiyan   +18 more
core   +2 more sources

Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma

Nature Communications, 2018
Genetic loci linked to susceptibility for the common skin cancer cutaneous squamous cell carcinoma (cSCC) have been identified by genome wide association studies (GWAS).
Nilah M. Ioannidis, Wei Wang, Nicholas A. Furlotte, David A. Hinds, 23andMe Research Team, Carlos D. Bustamante, Eric Jorgenson, Maryam M. Asgari, Alice S. Whittemore   +8 more
doaj   +1 more source

Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. [PDF]

PLoS ONE, 2013
BACKGROUND:Familial aggregation of Chagas cardiac disease in T. cruzi-infected persons suggests that human genetic variation may be an important determinant of disease progression.
Xutao Deng, Ester C Sabino, Edecio Cunha-Neto, Antonio L Ribeiro, Barbara Ianni, Charles Mady, Michael P Busch, Mark Seielstad, REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology Donor Study-II Component International   +8 more
doaj   +1 more source

A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis. [PDF]

, 2011
BackgroundRheumatoid arthritis (RA) can be divided into two major subsets based on the presence or absence of antibodies to citrullinated peptide antigens (ACPA).
Alfredsson, Lars, Ding, Bo, Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study group, Klareskog, Lars, Ong, Rick TH, Padyukov, Leonid, Rönnelid, Johan, Seddighzadeh, Maria, Seielstad, Mark   +8 more
core  

Friendship and Natural Selection

, 2014
More than any other species, humans form social ties to individuals who are neither kin nor mates, and these ties tend to be with similar people. Here, we show that this similarity extends to genotypes.
Christakis, Nicholas A., Fowler, James H.   +1 more
core   +1 more source

A Bayesian graphical model for genome-wide association studies (GWAS)

The Annals of Applied Statistics, 2016
The analysis of GWAS data has long been restricted to simple models that cannot fully capture the genetic architecture of complex human diseases. As a shift from standard approaches, we propose here a general statistical framework for multi-SNP analysis of GWAS data based on a Bayesian graphical model.
Briollais, Laurent, Dobra, Adrian, Liu, Jinnan, Friedlander, Matt, Ozcelik, Hilmi, Massam, Hélène   +5 more
openaire   +3 more sources