Results 241 to 250 of about 188,567 (300)

Cardiometabolic Risk in First Degree Relatives of Women With Polycystic Ovary Syndrome (PCOS)

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Polycystic ovary syndrome (PCOS) is a common multisystem disorder with reproductive, cardiometabolic and psychological implications. Genetic factors play a role in the pathogenesis of PCOS. We sought to investigate the cardiometabolic health of first degree relatives (FDR) of women with PCOS.
Su Jen Chua, Xinyi Wu, Tahani Al Kindi, Bulent O. Yildiz, Aya Mousa, Loyal Pattuwage, Helena Teede, Anju E. Joham, Chau Thien Tay   +8 more
wiley   +1 more source

Disentangling the relationship between glucose, insulin and brain health: A UK Biobank study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Background Glycaemic traits are associated with poorer brain health and dementia risk. Recent advances in genetic instruments for specific glycaemic markers enable an in‐depth investigation of the likely nature of associations and underlying mechanisms between diabetes‐related mechanisms and brain health and dementia.
Andrew C. Mason, Nasri Fatih, Reecha Sofat, Christopher T. Rentsch, Liam Smeeth, Krishnan Bhaskaran, Nish Chaturvedi, Victoria Garfield   +7 more
wiley   +1 more source

Individualism and working from home

Economic Inquiry, EarlyView.
Abstract We show that culturally transmitted individualism is an important determinant of working from home (WFH). Using individual‐level data from the U.S. Current Population Survey (CPS) and the European Social Survey (ESS), we compare immigrants and their descendants from different cultural backgrounds residing in the same location.
Jan Bietenbeck, Natalie Irmert, Therese Nilsson   +2 more
wiley   +1 more source

Insights Into Hereditary Alpha‐Tryptasemia From a Genome‐Wide Association Study in Hymenoptera Venom Anaphylaxis

Clinical &Experimental Allergy, EarlyView.
Teresa Blanco‐Ramos, Raquel Cruz, Irene Fernández‐Franco, Mª Ángeles Vargas, Ángel Carracedo, Arturo González‐Quintela, Carmen Vidal   +6 more
wiley   +1 more source

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Genome-Wide Association Studies (GWAS)

2023
Most of the breeding targets are quantitative traits. In exploring the quantitative trait locus (QTL) system of a trait, linkage mapping was established using sparse polymerase chain reaction (PCR) markers. With the genome-wide sequencing technology advanced, genome-wide association study (GWAS) was developed for natural (germplasm) populations using ...
Jianbo, He, Junyi, Gai
openaire   +2 more sources

Genome-Wide Association Studies (GWAS)

2022
Genome-wide association studies (GWAS) are designed to find associations between genomic variants and a phenotype, usually a complex multifactorial disease. The idea for association studies in a large cohort was floated after linkage analysis, which proved extremely successful in the identification of causative genes for rare disorders, but it did not ...
Hafiza Noor Ul Ayan, Muhammad Tariq
openaire   +1 more source

Genome-Wide Association Studies (GWAS)

2012
Genome-wide association studies (GWAS) have revolutionized our understanding of common diseases at the molecular level. This chapter discusses these strategies and describes key recent successes in stroke.
Guillaume Pare, Matthew P. A. Henderson
openaire   +1 more source

Statistical Perspectives for Genome-Wide Association Studies (GWAS)

2014
In this chapter we consider some key elements in conducting a successful genome-wide association study or GWAS. The first step is to design the study well (Subheading 3.1), paying particular attention to case and control selection and achieving adequate sample size to deal with the large burden of multiple testing.
Jennifer H, Barrett, John C, Taylor, Mark M, Iles   +2 more
openaire   +2 more sources

Bioinformatics Challenges in Genome-Wide Association Studies (GWAS)

2014
Genome-wide association studies (GWAS) are a powerful tool for investigators to examine the human genome to detect genetic risk factors, reveal the genetic architecture of diseases and open up new opportunities for treatment and prevention. However, despite its successes, GWAS have not been able to identify genetic loci that are effective classifiers ...
Rishika, De, William S, Bush, Jason H, Moore   +2 more
openaire   +2 more sources

Genome-Wide Association Studies (GWAS) of Adiposity

2016
Adiposity is strongly heritable and one of the leading risk factors for type 2 diabetes, cardiovascular disease, cancer, and premature death. In the past 8 years, genome-wide association studies (GWAS) have greatly increased our understanding of the genes and biological pathways that regulate adiposity by identifying more than 100 novel susceptibility ...
Oskari Kilpeläinen, Tuomas, Ingelsson, Erik   +1 more
openaire   +2 more sources