Results 101 to 110 of about 2,597,991 (390)

Enhancement of de novo sequencing, assembly and annotation of the Mongolian gerbil genome with transcriptome sequencing and assembly from several different tissues

BMC Genomics, 2019
Background The Mongolian gerbil (Meriones unguiculatus) has historically been used as a model organism for the auditory and visual systems, stroke/ischemia, epilepsy and aging related research since 1935 when laboratory gerbils were separated from their ...
Shifeng Cheng, Yuan Fu, Yaolei Zhang, Wenfei Xian, Hongli Wang, Benedikt Grothe, Xin Liu, Xun Xu, Achim Klug, Elizabeth A. McCullagh   +9 more
doaj   +1 more source

Deconvolute individual genomes from metagenome sequences through short read clustering. [PDF]

, 2020
Metagenome assembly from short next-generation sequencing data is a challenging process due to its large scale and computational complexity. Clustering short reads by species before assembly offers a unique opportunity for parallel downstream assembly of
Deng, Li, Li, Kexue, Lu, Yakang, Shi, Lizhen, Wang, Lili, Wang, Zhong   +5 more
core  

Assembling draft genomes using contiBAIT [PDF]

Bioinformatics, 2017
Abstract Summary Massively parallel sequencing is now widely used, but data interpretation is only as good as the reference assembly to which it is aligned. While the number of reference assemblies has rapidly expanded, most of these remain at intermediate stages of completion, either as scaffold ...
O'Neill, Kieran, Hills, Mark, Gottlieb, Mike, Borkowski, Matthew, Karsan, Aly, Lansdorp, Peter M.   +5 more
openaire   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

A reference quality, fully annotated diploid genome from a Saudi individual

Scientific Data
We have used multiple sequencing approaches to sequence the genome of a volunteer from Saudi Arabia. We use the resulting data to generate a de novo assembly of the genome, and use different computational approaches to refine the assembly.
Maxat Kulmanov, Rund Tawfiq, Yang Liu, Hatoon Al Ali, Marwa Abdelhakim, Mohammed Alarawi, Hind Aldakhil, Dana Alhattab, Ebtehal A. Alsolme, Azza Althagafi, Angel Angelov, Salim Bougouffa, Patrick Driguez, Changsook Park, Alexander Putra, Ana M. Reyes-Ramos, Charlotte A. E. Hauser, Ming Sin Cheung, Malak S. Abedalthagafi, Robert Hoehndorf   +19 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The chromosomal genome sequence of the sponge Cliona cf. orientalis Thiele (1900) and its associated microbial metagenome sequences [version 1; peer review: 1 approved, 2 approved with reservations, 1 not approved]

Wellcome Open Research
We present a genome assembly from a specimen of Cliona cf. orientalis (Porifera; Demospongiae; Clionaida; Clionaidae). The genome sequence has a total length of 217.17 megabases.
Emma Marangon, Eerik Aunin, Heidi M. Luter, Blake D. Ramsby, Patrick Laffy, Victoria McKenna, Sara C. Bell, Torsten Thomas, Nicole S. Webster, Ute Hentschel, Cara Fiore, Elizabeth Sinclair, Graeme Oatley, Camilla Santos, Noah Gettle, Haoyu Niu, Michael Paulini, Rebecca O’Brien   +17 more
doaj   +1 more source

Chromosome-level genome assembly of a parent species of widely cultivated azaleas

Nature Communications, 2020
Azaleas (Ericaceae) comprise one of the most diverse ornamental plants, renowned for their cultural and economic importance. We present a chromosome-scale genome assembly for Rhododendron simsii, the primary ancestor of azalea cultivars.
Fu-Sheng Yang, Shuai Nie, Hui Liu, Tian-Le Shi, Xue-Chan Tian, Shanshan Zhou, Yu-Tao Bao, Kaihua Jia, Jing-Fang Guo, Wei Zhao, Na An, Ren-Gang Zhang, Quan-zheng Yun, Xin-Zhu Wang, Chanaka Mannapperuma, I. Porth, Y. El-Kassaby, N. Street, Xiao‐Ru Wang, Y. Van de Peer, Jian-Feng Mao   +20 more
semanticscholar   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Fully phased human genome assembly without parental data using single-cell strand sequencing and long reads

Nature Biotechnology, 2020
Human genomes are typically assembled as consensus sequences that lack information on parental haplotypes. Here we describe a reference-free workflow for diploid de novo genome assembly that combines the chromosome-wide phasing and scaffolding ...
David Porubsky, Peter Ebert, P. Audano, Mitchell R. Vollger, William T. Harvey, P. Marijon, Jana Ebler, Katherine M. Munson, Melanie Sorensen, Arvis Sulovari, Marina Haukness, M. Ghareghani, P. Lansdorp, B. Paten, S. Devine, A. Sanders, Charles Lee, Mark J. P. Chaisson, J. Korbel, E. Eichler, T. Marschall   +20 more
semanticscholar   +1 more source