Results 11 to 20 of about 757,981 (296)
Optical map guided genome assembly [PDF]
BMC Bioinformatics, 2020 Background The long reads produced by third generation sequencing technologies have significantly boosted the results of genome assembly but still, genome-wide assemblies solely based on read data cannot be produced.
Miika Leinonen, Leena Salmela
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Genome assembly composition of the String “ACGT” array: a review of data structure accuracy and performance challenges [PDF]
PeerJ Computer Science, 2023 Background The development of sequencing technology increases the number of genomes being sequenced. However, obtaining a quality genome sequence remains a challenge in genome assembly by assembling a massive number of short strings (reads) with the ...
Sherif Magdy Mohamed Abdelaziz Barakat +4 more
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Effects of GC bias in next-generation-sequencing data on de novo genome assembly. [PDF]
PLoS ONE, 2013 Next-generation-sequencing (NGS) has revolutionized the field of genome assembly because of its much higher data throughput and much lower cost compared with traditional Sanger sequencing. However, NGS poses new computational challenges to de novo genome
Yen-Chun Chen +4 more
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Comparative genome assembly [PDF]
Briefings in Bioinformatics, 2004 One of the most complex and computationally intensive tasks of genome sequence analysis is genome assembly. Even today, few centres have the resources, in both software and hardware, to assemble a genome from the thousands or millions of individual sequences generated in a whole-genome shotgun sequencing project.
Mihai, Pop +3 more
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HGGA: hierarchical guided genome assembler
BMC Bioinformatics, 2022 AbstractBackgroundDe novogenome assembly typically produces a set of contigs instead of the complete genome. Thus additional data such as genetic linkage maps, optical maps, or Hi-C data is needed to resolve the complete structure of the genome. Most of the previous work uses the additional data to order and orient contigs.ResultsHere we introduce a ...
Salmela Leena, Walve Riku
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Wellcome Open Research, 2021 We present a genome assembly from an individual male Rattus norvegicus (the Norway rat; Chordata; Mammalia; Rodentia; Muridae). The genome sequence is 2.44 gigabases in span. The majority of the assembly is scaffolded into 20 chromosomal pseudomolecules,
Kerstin Howe +20 more
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Genome assembly of six polyploid potato genomes [PDF]
Scientific Data, 2020 AbstractGenome assembly of polyploid plant genomes is a laborious task as they contain more than two copies of the genome, are often highly heterozygous with a high level of repetitive DNA. Next Generation genome sequencing data representing one Chilean and five Peruvian polyploid potato (Solanum spp.) landrace genomes was used to construct genome ...
Maria Kyriakidou +4 more
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Wellcome Open Research, 2022 We present a genome assembly from an individual female Vespula germanica (the German wasp; Arthropoda; Insecta; Hymenoptera; Vespidae). The genome sequence is 206 megabases in span.
Liam M. Crowley
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The MaSuRCA genome assembler [PDF]
Bioinformatics, 2013 Abstract Motivation: Second-generation sequencing technologies produce high coverage of the genome by short reads at a low cost, which has prompted development of new assembly methods. In particular, multiple algorithms based on de Bruijn graphs have been shown to be effective for the assembly problem.
Aleksey V, Zimin +5 more
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Rapid genome mapping in nanochannel arrays for highly complete and accurate de novo sequence assembly of the complex Aegilops tauschii genome. [PDF]
PLoS ONE, 2013 Next-generation sequencing (NGS) technologies have enabled high-throughput and low-cost generation of sequence data; however, de novo genome assembly remains a great challenge, particularly for large genomes.
Alex R Hastie +12 more
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