Results 31 to 40 of about 452,095 (265)
Beware of mis-assembled genomes [PDF]
Bioinformatics, 2005 With hundreds of genomes now in GenBank, researchers might be forgiven for assuming that genome sequence data are correct, at least at a large scale. Certainly there might be errors at some small rate, perhaps 1 in 50 000 or 100 000 bases (Schmutz et al., 2004; Read et al., 2002), but at a large scale these genomes are put together correctly, are not ...
Steven Salzberg, James A. Yorke
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GTasm: a genome assembly method using graph transformers and HiFi reads
Frontiers in GeneticsMotivationGenome assembly aims to reconstruct the whole chromosome-scale genome sequence. Obtaining accurate and complete chromosome-scale genome sequence serve as an indispensable foundation for downstream genomics analyses.
Junwei Luo +4 more
doaj +1 more source
The genome sequence of the Common Brassy Ringlet, Erebia cassioides (Reiner & Hohenwarth, 1792) (Lepidoptera, Nymphalidae) [PDF]
Research Ideas and OutcomesWe present a chromosome-level genome assembly from a female specimen of the Common Brassy Ringlet Erebia cassioides (Arthropoda, Insecta, Lepidoptera, Nymphalidae).
Camille Cornet, Kay Lucek
doaj +3 more sources
Wellcome Open Research, 2021 We present a genome assembly from an individual female Rana temporaria (the common frog; Chordata; Amphibia; Anura; Ranidae). The genome sequence is 4.11 gigabases in span.
Jeffrey W. Streicher
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
, 2021 Msc in Computational Biology of Universidad Politécnica de Madrid (UPM) Course: Genomics Data Analysis and Visualization Lesson 3: Genome assembly This tutorial is designed to introduce the tools, data types and workflow for bacterial genome assembly.
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The Atlas Genome Assembly System [PDF]
Genome Research, 2004 Atlas is a suite of programs developed for assembly of genomes by a “combined approach” that uses DNA sequence reads from both BACs and whole-genome shotgun (WGS) libraries. The BAC clones afford advantages of localized assembly with reduced computational load, and provide a robust method for dealing with repeated sequences.
Paul, Havlak +7 more
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Wellcome Open ResearchWe present a genome assembly from a specimen of Ligustrum vulgare (wild privet; Streptophyta; Magnoliopsida; Lamiales; Oleaceae). The genome sequence has a total length of 1,384.00 megabases.
Michelle L. Hart +3 more
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source