Results 71 to 80 of about 4,666,723 (353)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
, 2021 Msc in Computational Biology of Universidad Politécnica de Madrid (UPM) Course: Genomics Data Analysis and Visualization Lesson 3: Genome assembly This tutorial is designed to introduce the tools, data types and workflow for bacterial genome assembly.
openaire +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Wellcome Open ResearchWe present a genome assembly of Melittis melissophyllum (Bastard Balm; Streptophyta; Magnoliopsida; Lamiales; Lamiaceae). The primary assembly has a total length of 436.70 megabases. Most of the primary assembly (97.71%) is scaffolded into 17 chromosomal
Sahr Mian +2 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Assessing genome assembly quality using the LTR Assembly Index (LAI)
Nucleic Acids Research, 2018 Assembling a plant genome is challenging due to the abundance of repetitive sequences, yet no standard is available to evaluate the assembly of repeat space.
Shujun Ou, Jin-Feng Chen, Ning Jiang
semanticscholar +1 more source
Improved chromosome-level genome assembly and annotation of the seagrass, Zostera marina (eelgrass)
F1000Research, 2021 Background: Seagrasses (Alismatales) are the only fully marine angiosperms. Zostera marina (eelgrass) plays a crucial role in the functioning of coastal marine ecosystems and global carbon sequestration.
Xiao Ma +10 more
semanticscholar +1 more source
The independence of our genome assemblies [PDF]
Proceedings of the National Academy of Sciences, 2003 The characterization, analysis, and conclusions of Waterston et al. (1) with regard to our published work (2, 3) are incorrect. Celera was founded with the goal of applying the whole genome shotgun (WGS) strategy to assemble the sequence of the human genome as rapidly as possible to advance the field of genomics (4).
Mark D, Adams +4 more
openaire +2 more sources
Wellcome Open ResearchWe present a genome assembly of Salix herbacea (Dwarf Willow; Streptophyta; Magnoliopsida; Malpighiales; Salicaceae). The primary assembly has a total length of 421.43 megabases.
Peter M. Hollingsworth, Markus Ruhsam
doaj +1 more source
Science Advances, 2021 High-quality genome assembly of ancient asexual rotifer reveals homologous chromosomes that frequently recombine.
P. Simion +26 more
semanticscholar +1 more source