Results 71 to 80 of about 2,481,819 (312)

BOA: A partitioned view of genome assembly

open access: yesiScience, 2022
Abstract De novo genome assembly is a fundamental problem in computational molecular biology that aims to reconstruct an unknown genome sequence from a set of short DNA sequences (or reads ) obtained from the genome.
Priyanka Ghosh   +8 more
openaire   +3 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Fully phased human genome assembly without parental data using single-cell strand sequencing and long reads [PDF]

open access: yes, 2021
Human genomes are typically assembled as consensus sequences that lack information on parental haplotypes. Here we describe a reference-free workflow for diploid de novo genome assembly that combines the chromosome-wide phasing and scaffolding ...
Sorensen, Melanie   +73 more
core   +1 more source

GAML: Genome Assembly by Maximum Likelihood [PDF]

open access: yesAlgorithms for Molecular Biology, 2014
Resolution of repeats and scaffolding of shorter contigs are critical parts of genome assembly. Modern assemblers usually perform such steps by heuristics, often tailored to a particular technology for producing paired or long reads.We propose a new framework that allows systematic combination of diverse sequencing datasets into a single assembly.
Vladimír Boza   +2 more
openaire   +3 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

transcriptome-and-genome-assembly: transcriptome-and-genome-assembly Version 1.0.0

open access: yes, 2015
<p><a href="url"></a></p> <p>Scripts to assemble de novo transcriptomes and genomes.</p> <a class="anchor" href="#pipelines-with-sample-data-sets"><span class="octicon octicon-link"></span></a ...
Jennifer Shelton
core   +1 more source

Genome sequence of the pea aphid Acyrthosiphon pisum [PDF]

open access: yes, 2010
Aphids are important agricultural pests and also biological models for studies of insect-plant interactions, symbiosis, virus vectoring, and the developmental causes of extreme phenotypic plasticity.
Fenton, Brian   +783 more
core   +1 more source

A chromosome-level genome assembly of the Korean minipig (Sus scrofa)

open access: yesScientific Data
Recent advancements in sequencing and genome assembly technologies have led to rapid generation of high-quality genome assemblies for various species and breeds.
Suyeon Wy   +5 more
doaj   +1 more source

A high-quality chromosome-level wild rice genome of Oryza coarctata

open access: yesScientific Data, 2023
Oryza coarctata (2n = 4X = 48, KKLL) is an allotetraploid, undomesticated relative of rice and the only species in the genus Oryza with tolerance to high salinity and submergence.
Hang Zhao   +11 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

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