Results 221 to 230 of about 1,963,187 (422)

Transfer of mitochondrial DNA into the nuclear genome during induced DNA breaks

Nature Communications
Mitochondria serve as the cellular powerhouse, and their distinct DNA makes them a prospective target for gene editing to treat genetic disorders. However, the impact of genome editing on mitochondrial DNA (mtDNA) stability remains a mystery.
Jinchun Wu, Yang Liu, Liqiong Ou, Tingting Gan, Zhengrong Zhangding, Shaopeng Yuan, Xinyi Liu, Mengzhu Liu, Jiasheng Li, Jianhang Yin, Changchang Xin, Ye Tian, Jiazhi Hu   +12 more
doaj   +1 more source

Chromosomal context and epigenetic mechanisms control the efficacy of genome editing by rare-cutting designer endonucleases [PDF]

, 2012
Fayza Daboussi, Mikhail Zaslavskiy, Laurent Poirot, Mariana Loperfido, Agnès Gouble, Valérie Guyot, Sophie Leduc, Román Galetto, Sylvestre Grizot, Danusia Oficjalska, Christophe Perez, Fabien Delacôte, Aurélie Dupuy, Isabelle Chion-Sotinel, Diane Le Clerre, Céline Lebuhotel, Olivier Danos, Frédéric Lemaire, Kahina Oussedik, Frédéric Cédrone, Jean-Charles Epinat, Julianne Smith, Rafael J. Yáñez‐Muñoz, George Dickson, Linda Popplewell, Taeyoung Koo, Thierry VandenDriessche, Marinee Chuah, Aymeric Duclert, Philippe Duchâteau, Frédéric Pâques   +30 more
openalex   +1 more source

KIF5A p.Pro986Leu Risk Variant and Accelerated Progression of Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study explored the impact of KIF5A rs113247976 (p.Pro986Leu), a risk allele for amyotrophic lateral sclerosis (ALS), on phenotypic variability in two Italian ALS cohorts (discovery, n = 865; replication, n = 1174). The minor allele (T) frequency was 0.015.
Arianna Manini, Rosario Vasta, Alberto Brusati, Francesco Scheveger, Silvia Peverelli, Alessio Maranzano, Alberto Doretti, Francesco Gentile, Eleonora Colombo, Maura Brunetti, Cristina Moglia, Antonio Canosa, Umberto Manera, Maurizio Grassano, Davide Gentilini, Stefano Messina, Federico Verde, Claudia Morelli, John E. Landers, Bryan J. Traynor, Adriano Chiò, Vincenzo Silani, Andrea Calvo, Antonia Ratti, Nicola Ticozzi   +24 more
wiley   +1 more source

Genome Editing with CompoZr Custom Zinc Finger Nucleases (ZFNs) [PDF]

, 2012
Keith Hansen, Matthew J. Coussens, Jack Sago, Shilpi Subramanian, Monika Gjoka, Dave Briner   +5 more
openalex   +1 more source

Scaling Up Synthetic Cell Production Using Robotics and Machine Learning Toward Therapeutic Applications

Advanced Biology, EarlyView.
Synthetic cells (SCs) hold great promise for biomedical applications, but manual production limits scalability. This study presents an automated method for large‐scale SC synthesis, integrating robotic liquid handling and machine learning‐driven high‐throughput characterization.
Noga Sharf‐Pauker, Ido Galil, Omer Kfir, Gal Chen, Rotem Menachem, Jeny Shklover, Avi Schroeder, Shanny Ackerman   +7 more
wiley   +1 more source

Genome Editing of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells With Zinc Finger Nucleases for Cellular Imaging [PDF]

, 2012
Yongming Wang, Wendy Y. Zhang, Shijun Hu, Feng Lan, Andrew S. Lee, Bruno Hüber, Leszek Lisowski, Ping Liang, Mei Huang, Patricia E. de Almeida, Jong Hak Won, Ning Sun, Robert C. Robbins, Mark A. Kay, Fyodor D. Urnov, Joseph C. Wu   +15 more
openalex   +1 more source

Engineering Novel DNA Nanoarchitectures for Targeted Drug Delivery and Aptamer Mediated Apoptosis in Cancer Therapeutics

Advanced Functional Materials, EarlyView.
Designer DNA Architecture‐templated Drug Conjugates (DDA‐DCs) are comprised of a DNA nanomaterial decorated with multiple drug‐loaded DNA aptamers. DDA‐DCs use a combination of multiple aptamer types, each recognizing a different membrane protein to achieve precise targeting of cancer cells.
Abhisek Dwivedy, Dhyanesh Baskaran, Gaurav Sharma, Wei Hong, Dhanush Gandavadi, Abhichart Krissanaprasit, Joonsu Han, Yusheng Liu, Zack Zimmers, Tshepo Mafokwane, Ichrak Hayah, Neha Chauhan, Mengxi Zheng, Sherwood Yao, Keith Fraser, John S. Decker, Xiaohe Jin, Hua Wang, Adam D. Friedman, Xing Wang   +19 more
wiley   +1 more source

The genome-editing decade

Molecular Therapy, 2021
Paula M. Cannon, Hans-Peter Kiem
openaire   +3 more sources

Bioengineering a Patient‐Derived Vascularized Lung Tumor‐on‐Chip Model to Decipher Immunomodulation by the Endothelium

Advanced Healthcare Materials, EarlyView.
Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche, Ségolène Ladaigue, Giacomo Gropplero, Nicolas Zimmermann, Martin Nurmik, Irina Veith, Manh‐Louis Nguyen, Solenn Brosseau, Nicolas Poté, Pierre Mordant, Arnaud Roussel, Fathia Mami‐Chouaib, Fatima Mechta‐Grigoriou, Gérard Zalcman, Fabrice Soncin, Stéphanie Descroix, Maria Carla Parrini   +16 more
wiley   +1 more source

Simple and precise targeted editing of the human genome using rAAV-mediated homologous recombination [PDF]

, 2012
C Torrance
openalex   +1 more source