Results 41 to 50 of about 1,436,995 (311)
Challenges Facing CRISPR/Cas9-Based Genome Editing in Plants
Frontiers in Plant Science, 2022 The development of plant varieties with desired traits is imperative to ensure future food security. The revolution of genome editing technologies based on the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated nuclease ...
Seungmin Son, Sang Ryeol Park
semanticscholar +1 more source
GENT2: an updated gene expression database for normal and tumor tissues
BMC Medical Genomics, 2019 Background Gene Expression database of Normal and Tumor tissues 2 (GENT2) is an updated version of GENT, which has provided a user-friendly search platform for gene expression patterns across different normal and tumor tissues compiled from public gene ...
Seung-Jin Park +3 more
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CRISPOR: intuitive guide selection for CRISPR/Cas9 genome editing experiments and screens
Nucleic Acids Res., 2018 CRISPOR.org is a web tool for genome editing experiments with the CRISPR–Cas9 system. It finds guide RNAs in an input sequence and ranks them according to different scores that evaluate potential off-targets in the genome of interest and predict on ...
J. Concordet, M. Haeussler
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CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy
Science Advances, 2020 CRISPR lipid nanoparticles promote in vivo therapeutic genome editing in two aggressive cancer mouse models. Harnessing CRISPR-Cas9 technology for cancer therapeutics has been hampered by low editing efficiency in tumors and potential toxicity of ...
Daniel Rosenblum +11 more
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Genome editing around the globe: An update on policies and perceptions
Plant Physiology, 2022 A decade ago, the CRISPR/Cas system has been adapted for genome editing. Since then, hundreds of organisms have been altered using genome editing and discussions were raised on the regulatory status of genome edited organisms esp. crops.
T. Sprink, R. Wilhelm, F. Hartung
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Antibiotic Resistance in Neisseria gonorrhoeae: Challenges in Research and Treatment
Microorganisms, 2022 Gonococcal infection caused by the Gram-negative bacteria Neisseria gonorrhoeae is one of the most common sexually transmitted infections (STIs) worldwide [...]
Boris Shaskolskiy +3 more
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Genome Editing for Sustainable Agriculture in Africa
Frontiers in Genome Editing, 2022 Sustainable intensification of agriculture in Africa is essential for accomplishing food and nutritional security and addressing the rising concerns of climate change.
L. Tripathi +7 more
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Advances in biotechnology: Genomics and genome editing
The EuroBiotech Journal, 2017 Abstract Genomics, the study of genes, their functions and related techniques has become a crucial science for developing understanding of life processes and how they evolve. Since the advent of the human genome project, huge strides have been made in developing understanding of DNA and RNA sequence information and how it can be put to ...
Gartland, Jill S. +4 more
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Large-Scale CRISPR Screen of LDLR Pathogenic Variants
Research, 2023 Familial hypercholesterolemia (FH) is a frequently occurring genetic disorder that is linked to early-onset cardiovascular disease. If left untreated, patients with this condition can develop severe cardiovascular complications.
Mengjing Li +9 more
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The Role of Recombinant AAV in Precise Genome Editing
Frontiers in Genome Editing, 2022 The replication-defective, non-pathogenic, nearly ubiquitous single-stranded adeno-associated viruses (AAVs) have gained importance since their discovery about 50 years ago.
Swati Bijlani +4 more
semanticscholar +1 more source