Results 41 to 50 of about 1,792,457 (385)
Genome Editing for CNS Disorders [PDF]
Frontiers in Neuroscience, 2020 Central nervous system (CNS) disorders have a social and economic burden on modern societies, and the development of effective therapies is urgently required. Gene editing may prevent or cure a disease by inducing genetic changes at endogenous loci. Genome editing includes not only the insertion, deletion or replacement of nucleotides, but also the ...
Fábio Duarte +3 more
openaire +5 more sources
CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing
Nucleic Acids Res., 2019 The CRISPR–Cas system is a powerful genome editing tool that functions in a diverse array of organisms and cell types. The technology was initially developed to induce targeted mutations in DNA, but CRISPR–Cas has now been adapted to target nucleic acids
Kornel Labun +5 more
semanticscholar +1 more source
Genome Editing for Sustainable Agriculture in Africa
Frontiers in Genome Editing, 2022 Sustainable intensification of agriculture in Africa is essential for accomplishing food and nutritional security and addressing the rising concerns of climate change.
L. Tripathi +7 more
semanticscholar +1 more source
GENT2: an updated gene expression database for normal and tumor tissues
BMC Medical Genomics, 2019 Background Gene Expression database of Normal and Tumor tissues 2 (GENT2) is an updated version of GENT, which has provided a user-friendly search platform for gene expression patterns across different normal and tumor tissues compiled from public gene ...
Seung-Jin Park +3 more
doaj +1 more source
Antibiotic Resistance in Neisseria gonorrhoeae: Challenges in Research and Treatment
Microorganisms, 2022 Gonococcal infection caused by the Gram-negative bacteria Neisseria gonorrhoeae is one of the most common sexually transmitted infections (STIs) worldwide [...]
Boris Shaskolskiy +3 more
doaj +1 more source
CRISPOR: intuitive guide selection for CRISPR/Cas9 genome editing experiments and screens
Nucleic Acids Res., 2018 CRISPOR.org is a web tool for genome editing experiments with the CRISPR–Cas9 system. It finds guide RNAs in an input sequence and ranks them according to different scores that evaluate potential off-targets in the genome of interest and predict on ...
J. Concordet, M. Haeussler
semanticscholar +1 more source
Nature Communications, 2020 Artificially improving traits of cultivated alfalfa (Medicago sativa L.), one of the most important forage crops, is challenging due to the lack of a reference genome and an efficient genome editing protocol, which mainly result from its autotetraploidy ...
Haitao Chen +23 more
semanticscholar +1 more source
The Role of Recombinant AAV in Precise Genome Editing
Frontiers in Genome Editing, 2022 The replication-defective, non-pathogenic, nearly ubiquitous single-stranded adeno-associated viruses (AAVs) have gained importance since their discovery about 50 years ago.
Swati Bijlani +4 more
semanticscholar +1 more source
Advances in biotechnology: Genomics and genome editing
The EuroBiotech Journal, 2017 Abstract Genomics, the study of genes, their functions and related techniques has become a crucial science for developing understanding of life processes and how they evolve. Since the advent of the human genome project, huge strides have been made in developing understanding of DNA and RNA sequence information and how it can be put to ...
Gartland, Jill S. +4 more
openaire +4 more sources
Comprehensive assessment of miniature CRISPR-Cas12f nucleases for gene disruption
Nature Communications, 2022 CRISPR-Cas12f nucleases can be effectively packaged into AAVs for gene therapy, but a systematic evaluation of editing outcomes is lacking. Here the authors perform a comprehensive assessment of 4 Cas12f proteins and compare to Cas9 and two Cas12a ...
Changchang Xin +6 more
doaj +1 more source