Results 41 to 50 of about 1,979,376 (400)

Genome editing technologies to fight infectious diseases [PDF]

open access: yes, 2017
Genome editing by programmable nucleases represents a promising tool that could be exploited to develop new therapeutic strategies to fight infectious diseases.
Barzon, Luisa   +2 more
core   +1 more source

Give CRISPR a chance : the GeneSprout Initiative [PDF]

open access: yes, 2020
Did you know that a group of early-career researchers launched an initiative enabling open dialog on new plant breeding techniques, such as genome editing?
Boer, Damian   +8 more
core   +2 more sources

Chromothripsis as an on-target consequence of CRISPR-Cas9 genome editing

open access: yesNature Genetics, 2020
Genome editing has therapeutic potential for treating genetic diseases and cancer. However, the currently most practicable approaches rely on the generation of DNA double-strand breaks (DSBs), which can give rise to a poorly characterized spectrum of ...
Mitchell L. Leibowitz   +8 more
semanticscholar   +1 more source

Mechanism and Applications of CRISPR/Cas-9-Mediated Genome Editing

open access: yesBiologics : targets & therapy, 2021
Clustered regularly interspaced short palindromic repeat (CRISPR) and their associated protein (Cas-9) is the most effective, efficient, and accurate method of genome editing tool in all living cells and utilized in many applied disciplines.
Misganaw Asmamaw, Belay Zawdie
semanticscholar   +1 more source

The hallmarks of dietary intervention-resilient gut microbiome

open access: yesnpj Biofilms and Microbiomes, 2022
Maintaining equilibrium of the gut microbiome is crucial for human health. Diet represents an important and generally accessible natural channel of controlling the nutrients supply to the intestinal microorganisms.
Natalia S. Klimenko   +3 more
doaj   +1 more source

CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing

open access: yesNucleic Acids Res., 2019
The CRISPR–Cas system is a powerful genome editing tool that functions in a diverse array of organisms and cell types. The technology was initially developed to induce targeted mutations in DNA, but CRISPR–Cas has now been adapted to target nucleic acids
Kornel Labun   +5 more
semanticscholar   +1 more source

Genome Editing for CNS Disorders [PDF]

open access: yesFrontiers in Neuroscience, 2020
Central nervous system (CNS) disorders have a social and economic burden on modern societies, and the development of effective therapies is urgently required. Gene editing may prevent or cure a disease by inducing genetic changes at endogenous loci. Genome editing includes not only the insertion, deletion or replacement of nucleotides, but also the ...
Fábio Duarte   +3 more
openaire   +5 more sources

In vivo genome editing using Staphylococcus aureus Cas9

open access: yesNature, 2015
The RNA-guided endonuclease Cas9 has emerged as a versatile genome-editing platform. However, the size of the commonly used Cas9 from Streptococcus pyogenes (SpCas9) limits its utility for basic research and therapeutic applications that use the highly ...
F. Ran   +12 more
semanticscholar   +1 more source

Improved genome editing by an engineered CRISPR-Cas12a

open access: yesbioRxiv, 2022
CRISPR-Cas12a is an RNA-guided, programmable genome editing enzyme found within bacterial adaptive immune pathways. Unlike CRISPR-Cas9, Cas12a uses only a single catalytic site to both cleave target double-stranded DNA (dsDNA) (cis-activity) and ...
E. Ma   +8 more
semanticscholar   +1 more source

GENT2: an updated gene expression database for normal and tumor tissues

open access: yesBMC Medical Genomics, 2019
Background Gene Expression database of Normal and Tumor tissues 2 (GENT2) is an updated version of GENT, which has provided a user-friendly search platform for gene expression patterns across different normal and tumor tissues compiled from public gene ...
Seung-Jin Park   +3 more
doaj   +1 more source

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