Results 41 to 50 of about 1,979,376 (400)
Genome editing technologies to fight infectious diseases [PDF]
, 2017 Genome editing by programmable nucleases represents a promising tool that could be exploited to develop new therapeutic strategies to fight infectious diseases.
Barzon, Luisa +2 more
core +1 more source
Give CRISPR a chance : the GeneSprout Initiative [PDF]
, 2020 Did you know that a group of early-career researchers launched an initiative enabling open dialog on new plant breeding techniques, such as genome editing?
Boer, Damian +8 more
core +2 more sources
Chromothripsis as an on-target consequence of CRISPR-Cas9 genome editing
Nature Genetics, 2020 Genome editing has therapeutic potential for treating genetic diseases and cancer. However, the currently most practicable approaches rely on the generation of DNA double-strand breaks (DSBs), which can give rise to a poorly characterized spectrum of ...
Mitchell L. Leibowitz +8 more
semanticscholar +1 more source
Mechanism and Applications of CRISPR/Cas-9-Mediated Genome Editing
Biologics : targets & therapy, 2021 Clustered regularly interspaced short palindromic repeat (CRISPR) and their associated protein (Cas-9) is the most effective, efficient, and accurate method of genome editing tool in all living cells and utilized in many applied disciplines.
Misganaw Asmamaw, Belay Zawdie
semanticscholar +1 more source
The hallmarks of dietary intervention-resilient gut microbiome
npj Biofilms and Microbiomes, 2022 Maintaining equilibrium of the gut microbiome is crucial for human health. Diet represents an important and generally accessible natural channel of controlling the nutrients supply to the intestinal microorganisms.
Natalia S. Klimenko +3 more
doaj +1 more source
CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing
Nucleic Acids Res., 2019 The CRISPR–Cas system is a powerful genome editing tool that functions in a diverse array of organisms and cell types. The technology was initially developed to induce targeted mutations in DNA, but CRISPR–Cas has now been adapted to target nucleic acids
Kornel Labun +5 more
semanticscholar +1 more source
Genome Editing for CNS Disorders [PDF]
Frontiers in Neuroscience, 2020 Central nervous system (CNS) disorders have a social and economic burden on modern societies, and the development of effective therapies is urgently required. Gene editing may prevent or cure a disease by inducing genetic changes at endogenous loci. Genome editing includes not only the insertion, deletion or replacement of nucleotides, but also the ...
Fábio Duarte +3 more
openaire +5 more sources
In vivo genome editing using Staphylococcus aureus Cas9
Nature, 2015 The RNA-guided endonuclease Cas9 has emerged as a versatile genome-editing platform. However, the size of the commonly used Cas9 from Streptococcus pyogenes (SpCas9) limits its utility for basic research and therapeutic applications that use the highly ...
F. Ran +12 more
semanticscholar +1 more source
Improved genome editing by an engineered CRISPR-Cas12a
bioRxiv, 2022 CRISPR-Cas12a is an RNA-guided, programmable genome editing enzyme found within bacterial adaptive immune pathways. Unlike CRISPR-Cas9, Cas12a uses only a single catalytic site to both cleave target double-stranded DNA (dsDNA) (cis-activity) and ...
E. Ma +8 more
semanticscholar +1 more source
GENT2: an updated gene expression database for normal and tumor tissues
BMC Medical Genomics, 2019 Background Gene Expression database of Normal and Tumor tissues 2 (GENT2) is an updated version of GENT, which has provided a user-friendly search platform for gene expression patterns across different normal and tumor tissues compiled from public gene ...
Seung-Jin Park +3 more
doaj +1 more source