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Plant Genome Engineering for Targeted Improvement of Crop Traits [PDF]

Frontiers in Plant Science, 2019
To improve food security, plant biology research aims to improve crop yield and tolerance to biotic and abiotic stress, as well as increasing the nutrient contents of food. Conventional breeding systems have allowed breeders to produce improved varieties
Khalid E. M. Sedeek, Ahmed Mahas, Magdy Mahfouz   +2 more
doaj   +2 more sources

Systematic optimization of prime editing for enhanced efficiency and versatility in genome engineering across diverse cell types [PDF]

Frontiers in Cell and Developmental Biology
Prime editing offers remarkable versatility in genome editing, but its efficiency remains a major bottleneck. While continuous optimization of the prime editing enzymes and guide RNAs (pegRNAs) has improved editing outcomes, the method of delivery also ...
Huiling Mu, Huiling Mu, Yeyi Liu, Yeyi Liu, Yijia Chi, Yijia Chi, Fei Wang, Shuting Meng, Shuting Meng, Yi Zhang, Yi Zhang, Xunting Wang, Xunting Wang, Dongxin Zhao, Dongxin Zhao, Dongxin Zhao   +15 more
doaj   +2 more sources

Genome engineering: writing a better genome

BioTechniques, 2012
Jeffrey M. Perkel
doaj   +2 more sources

CRISPR/Cas-Mediated Genome Engineering in Plants: Application and Prospectives [PDF]

Plants
Genetic engineering has become an essential element in developing climate-resilient crops and environmentally sustainable solutions to respond to the increasing need for global food security.
Swetaleena Mishra, Subhendu Nayak, Narendra Tuteja, Sowmya Poosapati, Durga Madhab Swain, Ranjan Kumar Sahoo   +5 more
doaj   +2 more sources

Isolation, Characterization, and Genome Engineering of a Lytic Pseudomonas aeruginosa Phage [PDF]

Microorganisms
Antibiotic-resistant bacterial infections have become one of the leading causes of human mortality. Bacteriophages presented great potential for combating antibiotic-resistant infections in the post-antibiotic era due to their high host specificity and ...
Xiaomei Cong, Shuang Zhao, Qing Zhang, Shuo Liu, Youming Zhang, Fu Yan   +5 more
doaj   +2 more sources

Porcine germline genome engineering [PDF]

Proceedings of the National Academy of Sciences, 2021
Germline editing, the process by which the genome of an individual is edited in such a way that the change is heritable, has been applied to a wide variety of animals [D. A. Sorrell, A. F. Kolb, Biotechnol. Adv. 23, 431–469 (2005); D. Baltimore et al., Science 348, 36–38 (2015)].
Luhan Yang, George Church, Hong-Ye Zhao, Lusheng Huang, Yangbin Gao, Hong-Jiang Wei, Geoffrey Yang   +6 more
openaire   +2 more sources

Defect-complementation homologous recombination: A novel strategy for precise genome engineering of virulent phages. [PDF]

Synth Syst Biotechnol
Zhang H, Song Y, Liu W, Zheng X, An X, Li C, Chen W, Wang H, Zhang Y.   +8 more
europepmc   +2 more sources

Enabling functional genomics with genome engineering [PDF]

Genome Research, 2015
Advances in genome engineering technologies have made the precise control over genome sequence and regulation possible across a variety of disciplines. These tools can expand our understanding of fundamental biological processes and create new opportunities for therapeutic designs.
Hilton, Isaac B., Gersbach, Charles A.
openaire   +2 more sources

The Rice Serine/Arginine Splicing Factor RS33 Regulates Pre-mRNA Splicing during Abiotic Stress Responses

Cells, 2022
Abiotic stresses profoundly affect plant growth and development and limit crop productivity. Pre-mRNA splicing is a major form of gene regulation that helps plants cope with various stresses.
Haroon Butt, Jeremie Bazin, Kasavajhala V. S. K. Prasad, Nourelislam Awad, Martin Crespi, Anireddy S. N. Reddy, Magdy M. Mahfouz   +6 more
doaj   +1 more source

Gene editing tools for mycoplasmas: references and future directions for efficient genome manipulation

Frontiers in Microbiology, 2023
Mycoplasmas are successful pathogens that cause debilitating diseases in humans and various animal hosts. Despite the exceptionally streamlined genomes, mycoplasmas have evolved specific mechanisms to access essential nutrients from host cells.
Gang Zhao, Gang Zhao, Gang Zhao, Doukun Lu, Min Li, Min Li, Yujiong Wang, Yujiong Wang   +7 more
doaj   +1 more source