Results 121 to 130 of about 526,413 (332)

Genetic Engineering and Genome Editing Advances to Enhance Floral Attributes in Ornamental Plants: An Update [PDF]

, 2023
Manjulatha Mekapogu, Hyun-Young Song, So-Hyeon Lim, Jae‐A Jung   +3 more
openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

DNA on the move: mechanisms, functions and applications of transposable elements

FEBS Open Bio
Transposons are mobile genetic elements that have invaded all domains of life by moving between and within their host genomes. Due to their mobility (or transposition), transposons facilitate horizontal gene transfer in bacteria and foster the evolution ...
Michael Schmitz, Irma Querques
doaj   +1 more source

Engineering the Drosophila Genome for Developmental Biology

Journal of Developmental Biology, 2017
The recent development of transposon and CRISPR-Cas9-based tools for manipulating the fly genome in vivo promises tremendous progress in our ability to study developmental processes.
Dagmara Korona, Stefan A. Koestler, Steven Russell   +2 more
doaj   +1 more source

Engineering modification of genome-reduced strain Bacillus amyloliquefaciens for enhancing surfactin production [PDF]

, 2020
Fang Zhang, Kaiyue Huo, Xingyi Song, Yufen Quan, Weixia Gao, Shufang Wang, Chao Yang   +6 more
openalex   +1 more source

Mastering targeted genome engineering of GC-rich oleaginous yeast for tailored plant oil alternatives for the food and chemical sector [PDF]

, 2023
Pariya Shaigani, Tobias A. Fuchs, Petra Graban, Sophia Prem, Martina Haack, Mahmoud Masri, Norbert Mehlmer, Thomas Brueck   +7 more
openalex   +1 more source

Genealogical Distance as a Diversity Estimate in Evolutionary Algorithms

, 2017
The evolutionary edit distance between two individuals in a population, i.e., the amount of applications of any genetic operator it would take the evolutionary process to generate one individual starting from the other, seems like a promising estimate ...
Belzner, Lenz, Gabor, Thomas
core   +1 more source

GenEpi: gene-based epistasis discovery using machine learning. [PDF]

, 2020
BackgroundGenome-wide association studies (GWAS) provide a powerful means to identify associations between genetic variants and phenotypes. However, GWAS techniques for detecting epistasis, the interactions between genetic variants associated with ...
Alzheimer’s Disease Neuroimaging Initiative, Chang, Yu-Chuan, Chen, Chien-Yu, Giacomini, Kathleen M, Hong, Ming-Yi, Hsieh, Ping-Han, Oyang, Yen-Jen, Tung, Yi-An, Wu, June-Tai, Yee, Sook Wah   +9 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Engineering the Direct Repeat Sequence of crRNA for Optimization of FnCpf1-Mediated Genome Editing in Human Cells [PDF]

, 2018
Lin Li, Xiubin He, Tianyuan Zhao, Lingkai Gu, Yeqing Liu, Xiaoyu Liu, Hongyan Liu, Fayu Yang, Mengjun Tu, Lianchao Tang, Xianglian Ge, Changbao Liu, Junzhao Zhao, Zongming Song, Jia Qu, Feng Gu   +15 more
openalex   +1 more source