Results 251 to 260 of about 3,706,718 (308)

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

A Near Telomere-to-Telomere Genome of Belamcanda chinensis Provides Insights Into Genome Evolution and the Biosynthesis of Characteristic Isoflavones. [PDF]

Plant Biotechnol J
Wang YY, Chen BH, Xiang GS, Wang YN, Yang R, Li XB, Yuan SY, Zhao YC, Zhang GH, Qin MJ, Yang SC.   +10 more
europepmc   +1 more source

Bi‐ and Mono‐Allelic RFC1 Expansion in a North American Cohort With Idiopathic Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective RFC1 biallelic repeat expansion is increasingly recognized as a cause of chronic idiopathic axonal polyneuropathy (CIAP), but it remains challenging to know who to test. This study aims to determine the prevalence of biallelic and monoallelic RFC1 expansions and their corresponding neuropathy phenotypes in CIAP patients and identify ...
Amro M. Stino, Lavanya Muthukumar, Evan L. Reynolds, Peter Todd, Sinem Ovunc, Sheng Chih Jin, Zitian Tang, Simone Thomas, PNRR Study Group, Ahmet Höke, Brian C. Callaghan, Sarah Berth, Vinay Chaudhry, David Cornblath, Leana Doherty, Lindsey Hayes, Hristelina Ilieva, Thomas Lloyd, Mohammad Khoshnoodi, Brett McCray, Brett Morrison, Bipasha Mukherjee‐Clavin, Lyle Ostrow, Michael Polydefkis, Ricardo Roda, Charlotte Sumner   +25 more
wiley   +1 more source

Cathepsin B protease mediates high population density-induced mutagenesis to drive genome evolution and competitive growth. [PDF]

Nat Commun
Yu B, Suehiro Y, Johnson BJ, Lee ES, Li D, Huang Y, Johnson J, Ou G, DeGregori J, Mitani S, Xue D.   +10 more
europepmc   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Domestication and genome evolution in <i>Allium</i> crops: From hybrid origins to breeding perspectives. [PDF]

iScience
Harding EA, Karbasi A, Fernie AR, Bulut M.   +3 more
europepmc   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Cross-feeding options define genome evolution and community assembly of deep groundwater microbiome. [PDF]

Environ Microbiome
Rezaei Somee M, González-Rosales C, Gralka M, Turner S, Bertilsson S, Dopson M, Mehrshad M.   +6 more
europepmc   +1 more source

Limited genome evolution of <i>Cryptococcus neoformans</i> following an accidental infection in the research laboratory. [PDF]

ASM Case Rep
Fan Y, Kulkarni M, Zhang SX, Timp W, Sullivan DJ, Smith DFQ, Casadevall A, Hardwick JM.   +7 more
europepmc   +1 more source

Assessment of genome evolution in <i>Bifidobacterium adolescentis</i> indicates genetic adaptation to the human gut. [PDF]

mSystems
Selleri E, Tarracchini C, Petraro S, Mancabelli L, Milani C, Turroni F, Shao Y, Browne HP, Lawley TD, van Sinderen D, Ventura M, Lugli GA.   +11 more
europepmc   +1 more source