Results 81 to 90 of about 874,950 (354)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

An agent-based modelling framework to study growth mechanisms in EGFR-L858R mutant cell alveolar type II cells

Royal Society Open Science
Mutations in the epidermal growth factor receptor (EGFR) are common in non-small cell lung cancer (NSCLC), particularly in never-smoker patients. However, these mutations are not always carcinogenic, and have recently been reported in histologically ...
Helena Coggan, Clare E. Weeden, Philip Pearce, Mohit P. Dalwadi, Alastair Magness, Charles Swanton, Karen M. Page   +6 more
doaj   +1 more source

Hybridization and adaptive evolution of diverse Saccharomyces species for cellulosic biofuel production

Biotechnology for Biofuels, 2017
Background Lignocellulosic biomass is a common resource across the globe, and its fermentation offers a promising option for generating renewable liquid transportation fuels.
David Peris, Ryan V. Moriarty, William G. Alexander, EmilyClare Baker, Kayla Sylvester, Maria Sardi, Quinn K. Langdon, Diego Libkind, Qi-Ming Wang, Feng-Yan Bai, Jean-Baptiste Leducq, Guillaume Charron, Christian R. Landry, José Paulo Sampaio, Paula Gonçalves, Katie E. Hyma, Justin C. Fay, Trey K. Sato, Chris Todd Hittinger   +18 more
doaj   +1 more source

Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry

Nature Communications, 2021
The tumour microenvironment (TME) may change in response to cancer treatments such as KRAS G12C inhibition, with potential implications for combination therapies. Here, the authors provide an antibody panel and workflow for analysing the TME with imaging
Febe van Maldegem, Karishma Valand, Megan Cole, Harshil Patel, Mihaela Angelova, Sareena Rana, Emma Colliver, Katey Enfield, Nourdine Bah, Gavin Kelly, Victoria Siu Kwan Tsang, Edurne Mugarza, Christopher Moore, Philip Hobson, Dina Levi, Miriam Molina-Arcas, Charles Swanton, Julian Downward   +17 more
doaj   +1 more source

Genes Translocated into the Plastid Inverted Repeat Show Decelerated Substitution Rates and Elevated GC Content. [PDF]

, 2016
Plant chloroplast genomes (plastomes) are characterized by an inverted repeat (IR) region and two larger single copy (SC) regions. Patterns of molecular evolution in the IR and SC regions differ, most notably by a reduced rate of nucleotide substitution ...
Kuo, Li-Yaung, Li, Fay-Wei, Pryer, Kathleen, Rothfels, Carl   +3 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Genome Evolution: Recombination Speeds Up Adaptive Evolution [PDF]

Current Biology, 2003
Mutual interference among linked genetic sites subject to selection may reduce the level of adaptation. A recent study detected this effect using data on protein sequence evolution and codon usage in Drosophila.
Marais, Gabriel, Charlesworth, Brian
openaire   +2 more sources

The effect of Wolbachia on gene expression in Drosophila paulistorum and its implications for symbiont-induced host speciation

BMC Genomics, 2019
Background The Neotropical fruit fly Drosophila paulistorum (Diptera: Drosophilidae) is a species complex in statu nascendi comprising six reproductively isolated semispecies, each harboring mutualistic Wolbachia strains. Although wild type flies of each
Guilherme C. Baião, Daniela I. Schneider, Wolfgang J. Miller, Lisa Klasson   +3 more
doaj   +1 more source

Escape from nonsense-mediated decay associates with anti-tumor immunogenicity

Nature Communications, 2020
The transcripts generated by frameshifts and indels in cancer are frequently degraded by nonsense mediated decay. Here, the authors show that some of these transcripts can escape this degradation mechanism and their prevalence correlates with tumour ...
Kevin Litchfield, James L. Reading, Emilia L. Lim, Hang Xu, Po Liu, Maise Al-Bakir, Yien Ning Sophia Wong, Andrew Rowan, Samuel A. Funt, Taha Merghoub, David Perkins, Martin Lauss, Inge Marie Svane, Göran Jönsson, Javier Herrero, James Larkin, Sergio A. Quezada, Matthew D. Hellmann, Samra Turajlic, Charles Swanton   +19 more
doaj   +1 more source

Reconstruction of Network Evolutionary History from Extant Network Topology and Duplication History

, 2012
Genome-wide protein-protein interaction (PPI) data are readily available thanks to recent breakthroughs in biotechnology. However, PPI networks of extant organisms are only snapshots of the network evolution.
A. Barabasi, A. Bhan, A. Vazquez, A. Wagner, I. Ispolatov, J. Bar-Ilan, J. Dutkowski, J. Pinney, L. Hakes, M. Middendorf, M. Stumpf, N. Farid, R. Pastor-Satorras, R. Patro, R. Sole, S. Navlakha, T. Yamada   +16 more
core   +1 more source