Results 1 to 10 of about 176,908 (324)

Genome-Guided Investigation Provides New Insights into Secondary Metabolites of Streptomyces parvulus SX6 from Aegiceras corniculatum

Polish Journal of Microbiology, 2022
Whole-genome sequencing and genome mining are recently considered an efficient approach to shine more light on the underlying secondary metabolites of Streptomyces.
Quach Ngoc Tung, Nguyen Vu Thi Hanh, Bui Thi Lien, Pham Anh Tuan, An Nguyen Thi Thu, Xuan Le Thi Thanh, Thuy Ta Thi Thu, Dudhagara Pravin, Phi Quyet-Tien   +8 more
doaj   +1 more source

Extraction of Transcript Diversity from Scientific Literature [PDF]

, 2005
Transcript diversity generated by alternative splicing and associated mechanisms contributes heavily to the functional complexity of biological systems.
Lars J Jensen, Parantu K Shah, Peer Bork, Philip Bourne, Stéphanie Boué   +4 more
core   +6 more sources

Genome Mining of Chryseobacterium proteolyticum for Keratinolytic Properties and Prospective Applications

Journal of Pure and Applied Microbiology
The manipulation of keratinolytic determinants provides an avenue for enhancing keratinase output, thereby facilitating the conversion of wasted chicken feathers into valuable products.
Lindelwa Mpaka, Nonso E. Nnolim, Uchechukwu U. Nwodo   +2 more
doaj   +1 more source

Expanding the Utility of Bioinformatic Data for the Full Stereostructural Assignments of Marinolides A and B, 24- and 26-Membered Macrolactones Produced by a Chemically Exceptional Marine-Derived Bacterium

Marine Drugs, 2023
Marinolides A and B, two new 24- and 26-membered bacterial macrolactones, were isolated from the marine-derived actinobacterium AJS-327 and their stereostructures initially assigned by bioinformatic data analysis.
Min Cheol Kim, Jaclyn M. Winter, Reiko Cullum, Alexander J. Smith, William Fenical   +4 more
doaj   +1 more source

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space? [PDF]

, 2006
The organization and mining of malaria genomic and post-genomic data is highly motivated by the necessity to predict and characterize new biological targets and new drugs. Biological targets are sought in a biological space designed from the genomic data
Bastien, Olivier, Birkholtz, Lyn-Marie, Breton, Vincent, Grando, Delphine, Hofmann-Apitius, Martin, Jacq, Nicolas, Joubert, Fourie, Kasam, Vinod, Louw, Abraham I, Maréchal, Eric, Ortet, Philippe, Roy, Sylvaine, Saïdani, Nadia, Wells, Gordon, Zimmermann, Marc   +14 more
core   +5 more sources

Increased Biological Activity of Aneurinibacillus migulanus Strains Correlates with the Production of New Gramicidin Secondary Metabolites [PDF]

, 2017
Acknowledgments This project was funded by the Government of Kuwait (to FA) and the European Union Seventh Framework Programme under grant agreement 245268 (ISEFOR; to LB and SW).
Alenezi, Faizah N., Belbahri, Lassaad, Bouket, Ali Chenari, Jaspars, Marcel, Luptakova, Lenka, Rateb, Mostafa E., Rekik, Imen, Weitz, Hedda, Woodward, Stephen   +8 more
core   +1 more source

Discovery of fungal onoceroid triterpenoids through domainless enzyme-targeted global genome mining

Nature Communications
Genomics-guided methodologies have revolutionized the discovery of natural products. However, a major challenge in the field of genome mining is determining how to selectively extract biosynthetic gene clusters (BGCs) for untapped natural products from ...
Jia Tang, Yudai Matsuda
doaj   +1 more source

A mass spectrometry-guided genome mining approach for natural product peptidogenomics. [PDF]

, 2011
Peptide natural products show broad biological properties and are commonly produced by orthogonal ribosomal and nonribosomal pathways in prokaryotes and eukaryotes.
Cimermancic, Peter, Dorrestein, Pieter C, Fenical, William, Fischbach, Michael A, Kersten, Roland D, Moore, Bradley S, Nam, Sang-Jip, Xu, Yuquan, Yang, Yu-Liang   +8 more
core  

The development of non-coding RNA ontology [PDF]

, 2016
Identification of non-coding RNAs (ncRNAs) has been significantly improved over the past decade. On the other hand, semantic annotation of ncRNA data is facing critical challenges due to the lack of a comprehensive ontology to serve as common data ...
Blake, Judith, de Silva, Nisansa, Dou, Deijing, Eilbeck, Karen, Huan, Jun, Huang, Jingshan, Huang, Weili, Jiang, Guoqian, Kasukurthi, Mohan Vamsi, Lin, Yu, Natale, Darren, Ruttenberg, Alan, Smith, Barry, Strachan, Harrison, Wu, Bin, Zimmermann, Michael   +15 more
core   +1 more source

The undiscovered biosynthetic potential of the Greenland Ice Sheet microbiome

Frontiers in Microbiology, 2023
The Greenland Ice Sheet is a biome which is mainly microbially driven. Several different niches can be found within the glacial biome for those microbes able to withstand the harsh conditions, e.g., low temperatures, low nutrient conditions, high UV ...
Ate H. Jaarsma, Athanasios Zervas, Katie Sipes, Francisco Campuzano Jiménez, Andrea Claire Smith, Liessel Victoria Svendsen, Mariane S. Thøgersen, Peter Stougaard, Liane G. Benning, Liane G. Benning, Martyn Tranter, Alexandre M. Anesio   +11 more
doaj   +1 more source