Results 1 to 10 of about 1,940,445 (217)

AcaFinder: Genome Mining for Anti-CRISPR-Associated Genes

mSystems, 2022
Anti-CRISPR (Acr) proteins are encoded by (pro)viruses to inhibit their host’s CRISPR-Cas systems. Genes encoding Acr and Aca (Acr associated) proteins often colocalize to form acr-aca operons.
Bowen Yang, Jinfang Zheng, Yanbin Yin
doaj   +2 more sources

Discovery of fungal onoceroid triterpenoids through domainless enzyme-targeted global genome mining

Nature Communications
Genomics-guided methodologies have revolutionized the discovery of natural products. However, a major challenge in the field of genome mining is determining how to selectively extract biosynthetic gene clusters (BGCs) for untapped natural products from ...
Jia Tang, Yudai Matsuda
doaj   +2 more sources

Mini review: Genome mining approaches for the identification of secondary metabolite biosynthetic gene clusters in Streptomyces

Computational and Structural Biotechnology Journal, 2020
Streptomyces are a large and valuable resource of bioactive and complex secondary metabolites, many of which have important clinical applications. With the advances in high throughput genome sequencing methods, various in silico genome mining strategies ...
Namil Lee, Soonkyu Hwang, Jihun Kim, Suhyung Cho, Bernhard Palsson, Byung-Kwan Cho   +5 more
doaj   +2 more sources

Genome Mining as New Challenge in Natural Products Discovery

Marine Drugs, 2020
Drug discovery is based on bioactivity screening of natural sources, traditionally represented by bacteria fungi and plants. Bioactive natural products and their secondary metabolites have represented the main source for new therapeutic agents, used as ...
Luisa Albarano, Roberta Esposito, Nadia Ruocco, Maria Costantini   +3 more
doaj   +2 more sources

Targeted Large-Scale Genome Mining and Candidate Prioritization for Natural Product Discovery

Marine Drugs, 2022
Large-scale genome-mining analyses have identified an enormous number of cryptic biosynthetic gene clusters (BGCs) as a great source of novel bioactive natural products.
Jessie James Limlingan Malit, Hiu Yu Cherie Leung, Pei-Yuan Qian   +2 more
doaj   +2 more sources

Molecular dynamics and simulation analysis against superoxide dismutase (SOD) target of Micrococcus luteus with secondary metabolites from Bacillus licheniformis recognized by genome mining approach

Saudi Journal of Biological Sciences, 2023
Micrococcus luteus, also known as M. luteus, is a bacterium that inhabits mucous membranes, human skin, and various environmental sources. It is commonly linked to infections, especially among individuals who have compromised immune systems. M. luteus is
Zabin K. Bagewadi, T. M. Yunus Khan, B. Gangadharappa, Ankita Kamalapurkar, Shaik Mohamed Shamsudeen, Deepak A. Yaraguppi   +5 more
semanticscholar   +1 more source

Machine Learning-Enabled Genome Mining and Bioactivity Prediction of Natural Products.

ACS Synthetic Biology, 2023
Natural products (NPs) produced by microorganisms and plants are a major source of drugs, herbicides, and fungicides. Thanks to recent advances in DNA sequencing, bioinformatics, and genome mining tools, a vast amount of data on NP biosynthesis has been ...
Yujie Yuan, Chengyou Shi, Huimin Zhao
semanticscholar   +1 more source

Genome mining unveils a class of ribosomal peptides with two amino termini

bioRxiv, 2023
The era of inexpensive genome sequencing and improved bioinformatics tools has reenergized the study of natural products, including the ribosomally synthesized and post-translationally modified peptides (RiPPs).
Hengqian Ren, Shravan R. Dommaraju, Chunshuai Huang, Haiyang Cui, Yuwei Pan, M. Nešić, Lingyang Zhu, D. Sarlah, D. Mitchell, Huimin Zhao   +9 more
semanticscholar   +1 more source

Genome Mining of Pseudomonas Species: Diversity and Evolution of Metabolic and Biosynthetic Potential

Molecules, 2021
Microbial genome sequencing has uncovered a myriad of natural products (NPs) that have yet to be explored. Bacteria in the genus Pseudomonas serve as pathogens, plant growth promoters, and therapeutically, industrially, and environmentally important ...
Khorshed Alam, Md. Mahmudul Islam, Caiyun Li, Sharmin Sultana, Lin Zhong, Qiyao Shen, Guangle Yu, Jinfang Hao, Youming Zhang, Ruijuan Li, Aiying Li   +10 more
doaj   +1 more source

Metabolome-guided genome mining of RiPP natural products.

TIPS - Trends in Pharmacological Sciences, 2023
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a chemically diverse class of metabolites. Many RiPPs show potent biological activities that make them attractive starting points for drug development.
Mitja M. Zdouc, J. V. D. van der Hooft, M. Medema   +2 more
semanticscholar   +1 more source