Results 1 to 10 of about 105,183 (129)
Genome mining for methanobactins [PDF]
BMC Biology, 2013 Methanobactins (Mbns) are a family of copper-binding natural products involved in copper uptake by methanotrophic bacteria. The few Mbns that have been structurally characterized feature copper coordination by two nitrogen-containing heterocycles next to thioamide groups embedded in a peptidic backbone of varying composition.
Kenney, Grace E, Rosenzweig, Amy C
core +4 more sources
Automated genome mining for natural products [PDF]
BMC Bioinformatics, 2009 Background Discovery of new medicinal agents from natural sources has largely been an adventitious process based on screening of plant and microbial extracts combined with bioassay-guided identification and natural product structure elucidation ...
Zajkowski James +4 more
doaj +4 more sources
The evolution of genome mining in microbes – a review [PDF]
Natural Product Reports, 2016 This article reviews the development of genome mining strategies in bacteria during the last decade.
Alanjary, Mohammad +2 more
core +5 more sources
Clinics in Laboratory Medicine, 2008 This article reviews important emerging statistical concepts, data mining techniques, and applications that have been recently developed and used for genomic data analysis. First, general background and some critical issues in genomic data mining are summarized.
Jae K, Lee +2 more
openaire +2 more sources
AcaFinder: Genome Mining for Anti-CRISPR-Associated Genes
mSystems, 2022 Anti-CRISPR (Acr) proteins are encoded by (pro)viruses to inhibit their host’s CRISPR-Cas systems. Genes encoding Acr and Aca (Acr associated) proteins often colocalize to form acr-aca operons.
Bowen Yang, Jinfang Zheng, Yanbin Yin
doaj +1 more source
Computational and Structural Biotechnology Journal, 2020 Streptomyces are a large and valuable resource of bioactive and complex secondary metabolites, many of which have important clinical applications. With the advances in high throughput genome sequencing methods, various in silico genome mining strategies ...
Namil Lee +5 more
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DGIdb: mining the druggable genome [PDF]
Nature Methods, 2013 The Drug-Gene Interaction database (DGIdb) mines existing resources that generate hypotheses about how mutated genes might be targeted therapeutically or prioritized for drug development. It provides an interface for searching lists of genes against a compendium of drug-gene interactions and potentially 'druggable' genes. DGIdb can be accessed at http:/
Malachi Griffith +22 more
openaire +2 more sources
Data Mining in Genomics and Proteomics [PDF]
BioMed Research International, 2005 There is no doubt that both computational biology and bioinformatics, and the interface of computer science and biology in general, are central to the future of biological research. The disciplines span a process that begins with data collection, analysis, classification, and integration, and ends with interpretation, modeling, visualization, and ...
Bensmail, Halima, Haoudi, Abdelali
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Effect of surface grain boundary density on preosteoblast proliferation on titanium
Materials Research Letters, 2020 Studies since 2004 have shown that the cytocompatibility of ultrafine grain (UG) commercial purity (CP) titanium exceeds that of coarse grain (CG) CP titanium (Ti) by 30% to 20-fold.
Terry C. Lowe +5 more
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Molecules, 2021 Microbial genome sequencing has uncovered a myriad of natural products (NPs) that have yet to be explored. Bacteria in the genus Pseudomonas serve as pathogens, plant growth promoters, and therapeutically, industrially, and environmentally important ...
Khorshed Alam +10 more
doaj +1 more source