Results 1 to 10 of about 1,743,487 (288)
Genome mining for methanobactins [PDF]
BMC Biology, 2013 Methanobactins (Mbns) are a family of copper-binding natural products involved in copper uptake by methanotrophic bacteria. The few Mbns that have been structurally characterized feature copper coordination by two nitrogen-containing heterocycles next to thioamide groups embedded in a peptidic backbone of varying composition.
Grace E. Kenney, Amy C. Rosenzweig
core +7 more sources
Discovery of fungal onoceroid triterpenoids through domainless enzyme-targeted global genome mining [PDF]
Nature CommunicationsGenomics-guided methodologies have revolutionized the discovery of natural products. However, a major challenge in the field of genome mining is determining how to selectively extract biosynthetic gene clusters (BGCs) for untapped natural products from ...
Jia Tang, Yudai Matsuda
doaj +3 more sources
Mining the chicken genome [PDF]
Genome Biology, 2002 The chicken EST repository gives access to a BLAST server dedicated to mining recently released sequence information from the chick large-scale expressed sequence tag (EST ...
David Chambers
openalex +3 more sources
Machine Learning-Enabled Genome Mining and Bioactivity Prediction of Natural Products. [PDF]
ACS Synth Biol, 2023 Natural products (NPs) produced by microorganisms and plants are a major source of drugs, herbicides, and fungicides. Thanks to recent advances in DNA sequencing, bioinformatics, and genome mining tools, a vast amount of data on NP biosynthesis has been ...
Yuan Y, Shi C, Zhao H.
europepmc +2 more sources
Genome mining reveals novel biosynthetic gene clusters in entomopathogenic bacteria. [PDF]
Sci Rep, 2023 The discovery of novel bioactive compounds produced by microorganisms holds significant potential for the development of therapeutics and agrochemicals.
Meesil W +9 more
europepmc +2 more sources
Identification of Two Distinct Stereoselective Lysine 5-Hydroxylases by Genome Mining Based on Alazopeptin Biosynthetic Enzymes. [PDF]
ChemistryEnzymes that catalyze regioselective and stereoselective hydroxylation of amino acids are useful tools for the synthesis of pharmaceuticals. AzpK is an unprecedented lysine 5‐hydroxylase that is involved in alazopeptin biosynthesis, although its ...
Kawai S +6 more
europepmc +2 more sources
Mining the genome for iron [PDF]
Nature, 2000 The level of iron in our blood is controlled by tightly regulating the amount of iron that is absorbed through the gut wall. This is a two-step process — iron is taken up in cells called enterocytes that line the gut, and then exported from the enterocytes into the bloodstream.
Jerry Kaplan, James P. Kushner
openalex +3 more sources
Genome Mining for New Enzyme Chemistry. [PDF]
ACS CatalA revolution in the field of biocatalysis has enabled scalable access to compounds of high societal values using enzymes. The construction of biocatalytic routes relies on the reservoir of available enzymatic transformations.
Nguyen DT, Mitchell DA, van der Donk WA.
europepmc +2 more sources
Reference Based Genome Compression [PDF]
, 2012 DNA sequencing technology has advanced to a point where storage is becoming the central bottleneck in the acquisition and mining of more data. Large amounts of data are vital for genomics research, and generic compression tools, while viable, cannot ...
Chern, Bobbie +5 more
core +3 more sources
Genome Mining as New Challenge in Natural Products Discovery
Marine Drugs, 2020 Drug discovery is based on bioactivity screening of natural sources, traditionally represented by bacteria fungi and plants. Bioactive natural products and their secondary metabolites have represented the main source for new therapeutic agents, used as ...
Luisa Albarano +3 more
doaj +2 more sources