Results 131 to 140 of about 1,743,586 (380)
Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization
Advanced Science, EarlyView.This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao +15 more
wiley +1 more source
Molecules, 2020 Planococcus faecalis AJ003T produces glycosyl-4,4′-diaponeurosporen-4′-ol-4-oic acid as its main carotenoid. Five carotenoid pathway genes were presumed to be present in the genome of P.
Jun Ho Lee, Jin Won Kim, Pyung Cheon Lee
doaj +1 more source
Cis-regulatory module detection using constraint programming [PDF]
, 2010 We propose a method for finding CRMs in a set of co-regulated genes. Each CRM consists of a set of binding sites of transcription factors. We wish to find CRMs involving the same transcription factors in multiple sequences.
Guns, Tias +3 more
core +1 more source
Genomic Mining for Aspergillus Natural Products
Chemistry & Biology, 2006 The genus Aspergillus is renowned for its ability to produce a myriad of bioactive secondary metabolites. Although the propensity of biosynthetic genes to form contiguous clusters greatly facilitates assignment of putative secondary metabolite genes in the completed Aspergillus genomes, such analysis cannot predict gene expression and, ultimately ...
Jeremy D. Glasner +5 more
openaire +3 more sources
An introduction to reconstructing ancestral genomes [PDF]
arXiv, 2006 Recent advances in high-throughput genomics technologies have resulted in the sequencing of large numbers of (near) complete genomes. These genome sequences are being mined for important functional elements, such as genes. They are also being compared and contrasted in order to identify other functional sequences, such as those involved in the ...
arxiv
Advanced Science, Volume 12, Issue 14, April 10, 2025.Staphylococcus aureus (S. aureus) infection induces persistent pain via toxins, leading to CGRP release from TRPV1+ nociceptive nerves. CGRP inhibits chemotactic factor release from CX3CR1+ synovial lining macrophages and suppresses their bactericidal activity. This study highlights neuroimmune interactions in chronic septic arthritis and suggests CGRP
Xinyu Fang +19 more
wiley +1 more source
Unveiling combinatorial regulation through the combination of ChIP information and in silico cis-regulatory module detection [PDF]
, 2012 Computationally retrieving biologically relevant cis-regulatory modules (CRMs) is not straightforward. Because of the large number of candidates and the imperfection of the screening methods, many spurious CRMs are detected that are as high scoring as ...
Fierro, Ana Carolina +5 more
core +2 more sources
Mining the genome and regulatory networks
Genome Biology, 2006 A report on the 16th International Conference on Genome Informatics (GIW 2005), Yokohama, Japan, 19-21 December 2005.
Potapov, Anatolij P., Wingender, Edgar
openaire +3 more sources
Association Rule Mining in Genomics [PDF]
International Journal of Computer Theory and Engineering, 2010 Association rules, used widely in the area of market basket analysis, can be applied to the analysis of expression data as well. Association rules can reveal biologically relevant associations between different genes or between environmental effects and gene expression.
M. K. Ghose +2 more
openaire +1 more source
Chemotherapy‐Mediated Induction of PD‐L1 via SEI1 Facilitates Myeloma Immune Evasion
Advanced Science, EarlyView.Chemotherapy induces DNA damage, activating cyclic guanosine monophosphate (GMP)‐adenosine monophosphate (AMP) synthase (cGAS)/stimulator of interferon genes (STING), which phosphorylates interferon regulatory factor 7 (IRF7) to drive SERTA‐containing domain 1 (SEI1) transcription.
Rui Chen +9 more
wiley +1 more source