Results 131 to 140 of about 105,282 (228)
Advanced Intelligent Systems, EarlyView.This article offers a comprehensive review of topic modeling techniques, tracing their evolution from inception to recent developments. It explores methods such as latent Dirichlet allocation, latent semantic analysis, non‐negative matrix factorization, probabilistic latent semantic analysis, Top2Vec, and BERTopic, highlighting their strengths ...
Pratima Kumari +6 more
wiley +1 more source
Android Malware Clustering through Malicious Payload Mining
, 2017 Clustering has been well studied for desktop malware analysis as an effective triage method. Conventional similarity-based clustering techniques, however, cannot be immediately applied to Android malware analysis due to the excessive use of third-party ...
I Santos +7 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.The NF‐hHRAS mouse model was generated through Chr15 E1 locus‐targeted integration of a 21 kb multicopy HRAS gene cluster. The NF‐hHRAS model demostrated tissue‐specific expression of human HRAS across multiple organs and low spontaneous tumorigenesis.
Susu Liu +12 more
wiley +1 more source
Biosynthese der Biphenomycine, einer Familie potenter Antibiotika
Angewandte Chemie, EarlyView.Der vollständige Biosyntheseweg der Biphenomycin‐Antibiotika wird aufgeklärt und offenbart eine einzigartige enzymatische Maschinerie mit einem bifunktionellen MNIO, einer regioselektiven Arginase, einem B12‐abhängigen rSAM für C,C‐Kupplung, Enzymen zur Hydroxylierung sowie einer zweifach spezifischen Metalloprotease.
Elisabeth Strunk +7 more
wiley +1 more source
Angewandte Chemie, EarlyView.Es wird über sechs bakterielle Terpensynthasen berichtet. Eine davon produziert instabiles Chitinosphaerol, das sich spontan in verschiedene bekannte Naturstoffe umwandelt, deren Struktur überarbeitet werden muss. Ein zweites Enzym liefert das thermisch labile Neodolabella‐1(14),2,7‐trien, das sich beim Erhitzen sequenziell in die Thermocyclene A–C ...
Heng Li +4 more
wiley +1 more source
Homoterpen‐Biosynthese in Pilzen
Angewandte Chemie, EarlyView.Der erste Homoterpen‐Biosyntheseweg im Reich der Pilze. Ein Methyltransferase und Terpenzyklase Paar bildet über Presodorifen ein einzigartiges Heptamethyl‐bicyclo[3.3.1]nonan‐Homoterpen. Dies zeigt, dass Homoterpen‐Biosynthese durch Addition einer C1‐Einheit an Terpendiphosphat‐Vorläufer vor Gerüstbildung nicht auf Bakterien beschränkt ist, sondern ...
Lin Zhou +5 more
wiley +1 more source
Genome Mining for New Enzyme Chemistry
ACS CatalysisA revolution in the field of biocatalysis has enabled scalable access to compounds of high societal values using enzymes. The construction of biocatalytic routes relies on the reservoir of available enzymatic transformations. A review of uncharacterized proteins predicted from genomic sequencing projects shows that a treasure trove of enzyme chemistry ...
Dinh T. Nguyen +2 more
openaire +2 more sources
Biosynthesis of the Biphenomycin Family of Potent Antibiotics
Angewandte Chemie International Edition, EarlyView.The complete biosynthetic pathway of the biphenomycin antibiotics is elucidated, revealing a unique enzymatic machinery featuring a bifunctional MNIO, a regioselective arginase, a B12‐dependent rSAM for C,C coupling, hydroxylation enzymology, and a metalloprotease with dual‐specificity.
Elisabeth Strunk +7 more
wiley +1 more source
Angewandte Chemie International Edition, EarlyView.Six bacterial terpene synthases are reported, one of which produces instable chitinosphaerol, which is spontaneously transformed into several known natural products requiring structural revision. A second enzyme yields thermally labile neodolabella‐1(14),2,7‐triene, which upon heating shows sequential conversion into thermocyclenes A–C.
Heng Li +4 more
wiley +1 more source