Results 21 to 30 of about 1,940,445 (217)
Journal of Fungi, 2023 Fungi represents a rich repository of taxonomically restricted, yet chemically diverse, secondary metabolites that are synthesised via specific metabolic pathways.
Suhad A. A. Al-Salihi, Fabrizio Alberti
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Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance Resistance gene–guided genome mining presents a solution to a longstanding challenge in natural product drug discovery by allowing the prediction of a natural product’s molecular target directly from the sequence of the gene cluster ...
Kyle L Dunbar +11 more
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Microorganisms, 2021 A promising keratin-degrading strain from the genus Chryseobacterium (Chryseobacterium sp. KMC2) was investigated using comparative genomic tools against three publicly available reference genomes to reveal the keratinolytic potential for biosynthesis of
Dingrong Kang +4 more
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Nucleic Acids Res., 2023 There is an urgent need to diversify the pipeline for discovering novel natural products due to the increase in multi-drug resistant infections. Like bacteria, fungi also produce secondary metabolites that have potent bioactivity and rich chemical ...
Turgut Mesut Yılmaz +3 more
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Underexplored bacteria as reservoirs of novel antimicrobial lipopeptides
Frontiers in Chemistry, 2022 Natural products derived from microorganisms play a prominent role in drug discovery as potential anti-infective agents. Over the past few decades, lipopeptides produced by particularly Bacillus, Pseudomonas, Streptomyces, Paenibacillus, and ...
Tanya Clements-Decker +3 more
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Genome mining reveals novel biosynthetic gene clusters in entomopathogenic bacteria
Scientific Reports, 2023 The discovery of novel bioactive compounds produced by microorganisms holds significant potential for the development of therapeutics and agrochemicals.
Wipanee Meesil +9 more
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Diversity, 2022 A yellow bacterium from marine agar, strain WHA3T, was isolated from the mantel of the Pacific oysters Crassostrea gigas in the Wilhelmshaven Sea in northern Germany.
Hani Pira +4 more
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Nucleic Acids Res., 2022 Much of the complexity within cells arises from functional and regulatory interactions among proteins. The core of these interactions is increasingly known, but novel interactions continue to be discovered, and the information remains scattered across ...
Damian Szklarczyk +12 more
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antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline
Nucleic Acids Res., 2019 Secondary metabolites produced by bacteria and fungi are an important source of antimicrobials and other bioactive compounds. In recent years, genome mining has seen broad applications in identifying and characterizing new compounds as well as in ...
K. Blin +7 more
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Genome mining methods to discover bioactive natural products
Natural product reports (Print), 2021 Covering: 2016 to 2021 With genetic information available for hundreds of thousands of organisms in publicly accessible databases, scientists have an unprecedented opportunity to meticulously survey the diversity and inner workings of life.
Katherine D. Bauman +3 more
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