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Clinics in Laboratory Medicine, 2008 This article reviews important emerging statistical concepts, data mining techniques, and applications that have been recently developed and used for genomic data analysis. First, general background and some critical issues in genomic data mining are summarized.
Sooyoung Cheon +2 more
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Journal of the American Chemical Society, 2022 Genome mining of cryptic natural products (NPs) remains challenging, especially in filamentous fungi, owing to their complex genetic regulation. Increasing evidence indicates that several epigenetic modifications often act cooperatively to control fungal
Fanglong Zhao +13 more
semanticscholar +1 more source
Data Mining in Genomics and Proteomics [PDF]
BioMed Research International, 2005 There is no doubt that both computational biology and bioinformatics, and the interface of computer science and biology in general, are central to the future of biological research. The disciplines span a process that begins with data collection, analysis, classification, and integration, and ends with interpretation, modeling, visualization, and ...
Abdelali Haoudi, Halima Bensmail
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Microbiology Spectrum, 2023 The prevalence of superbugs, represented by methicillin-resistant Staphylococcus aureus (MRSA), has become a serious clinical and public safety concern with rising incidence in hospitals.
Xi-Long Feng +11 more
doaj +1 more source
Recent development of antiSMASH and other computational approaches to mine secondary metabolite biosynthetic gene clusters [PDF]
, 2019 Many drugs are derived from small molecules produced by microorganisms and plants, so-called natural products. Natural products have diverse chemical structures, but the biosynthetic pathways producing those compounds are often organized as biosynthetic ...
Blin, Kai +3 more
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Esterases From Bifidobacteria Exhibit the Conversion of Albiflorin in Gut Microbiota
Frontiers in Microbiology, 2022 Bifidobacteria is an important microbe that inhabits the human gut. It is capable of metabolizing complex compounds in the human diet. Albiflorin, an antidepressant natural product from Radix Paeoniae Alba in China, is difficult to absorb after oral ...
Ran Peng +10 more
doaj +1 more source
Natural product reports (Print), 2022 Covering: 2010 to 2022Heterologous expression of natural product biosynthetic gene clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways, bottom-up investigation of biosynthetic enzymes, and engineered biosynthesis of new ...
Chen-Yu Chiang, M. Ohashi, Yi Tang
semanticscholar +1 more source
DGIdb: mining the druggable genome [PDF]
Nature Methods, 2013 The Drug-Gene Interaction database (DGIdb) mines existing resources that generate hypotheses about how mutated genes might be targeted therapeutically or prioritized for drug development. It provides an interface for searching lists of genes against a compendium of drug-gene interactions and potentially 'druggable' genes. DGIdb can be accessed at http:/
Malachi Griffith +22 more
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Effect of surface grain boundary density on preosteoblast proliferation on titanium
Materials Research Letters, 2020 Studies since 2004 have shown that the cytocompatibility of ultrafine grain (UG) commercial purity (CP) titanium exceeds that of coarse grain (CG) CP titanium (Ti) by 30% to 20-fold.
Terry C. Lowe +5 more
doaj +1 more source
Navigating and expanding the roadmap of natural product genome mining tools
Beilstein Journal of Organic Chemistry, 2022 Natural products are structurally highly diverse and exhibit a wide array of biological activities. As a result, they serve as an important source of new drug leads. Traditionally, natural products have been discovered by bioactivity-guided fractionation.
Friederike Biermann +2 more
semanticscholar +1 more source